Article
Chemistry, Inorganic & Nuclear
Fatemeh Hakimi, Maede Abroon, Somayeh Sadighian, Ali Ramazani
Summary: Graphene oxide/hydroxy apatite (GO/HAp) nanocomposites were synthesized using different ratios of HAp through a hydrothermal process. The impact of these ratios on the growth of bone-like HAp crystals was investigated, and the bioactivity of the GO/HAp nanocomposites was tested in a simulated body fluid solution. Characterization techniques such as FTIR, XRD, and TEM confirmed the successful synthesis of GO/HAp nanocomposites.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Materials Science, Ceramics
July Andrea Rincon-Lopez, Jennifer Andrea Hermann-Munoz, Nuria Cinca-Luis, David Andres Fernandez-Benavides, Irene Garcia-Cano, Jose Maria Guilemany-Casadamon, Aldo Roberto Boccaccini, Juan Munoz-Saldana, Juan Manuel Alvarado-Orozco
Summary: The Nagelschmidtite phase has the ability to promote osteogenesis, cementogenesis, and angiogenesis, with its chemical and structural properties affecting the formation and crystallization mechanism of apatite. The bioceramic exhibits a biomimetic behavior during apatite biomineralization, comparable to the formation process of Extra-Cellular Matrix (ECM) deposits in biological systems.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2021)
Article
Multidisciplinary Sciences
Mareeswari Paramasivan, T. S. Sampath Kumar, Hemalatha Kanniyappan, Vignesh Muthuvijayan, T. S. Chandra
Summary: Biomimicry has been adopted in bioceramics due to its functional advantages. In this study, hydroxyapatite synthesized via biomimetic approach was substituted with individual and multiple cations. The substituted hydroxyapatite showed decreased crystallinity, phase purity, and altered morphology. The co-substituted hydroxyapatite with 1% Sr, Zn, and Mg showed promising biocompatibility.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Applied
Joao P. Ribeiro, Rui M. A. Domingues, Pedro S. Babo, Liebert P. Nogueira, Janne E. Reseland, Rui L. Reis, Manuel Gomez-Florit, Manuela E. Gomes
Summary: Mineralized nanocomposite scaffolds can mimic bone ECM properties and have the potential to promote both osteogenesis and angiogenesis.
CARBOHYDRATE POLYMERS
(2022)
Article
Materials Science, Multidisciplinary
Hossein Aghamohammadi, Sayed Mahmood Rabiee, Seyed Jamal Hosseinipour, Roohollah Jamaati
Summary: Magnesium has unique biomedical properties such as biocompatibility and biodegradability, making it suitable for biomedical applications. This study investigates the relationship between the microstructure and crystalline texture of AZ31 magnesium alloy substrate, the morphology of calcium phosphate coating, and the corrosion behavior of the material. The results show that apatite crystals can form and grow on the surfaces of the biomimetic coating. The coating morphology is influenced by the microstructure and crystalline texture of the substrate. The corrosion resistance of the coated specimens is significantly improved compared to the uncoated specimens.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Chemistry, Multidisciplinary
Susrut Akkineni, Gregory S. Doerk, Chenyang Shi, Biao Jin, Shuai Zhang, Stefan Habelitz, James J. De Yoreo
Summary: The study demonstrates how the supramolecular structures of matrix proteins can be synthetically directed into predetermined patterns while retaining their functionality. They used block copolymer lamellar patterns to direct the assembly of peptide nanoribbons, which template calcium phosphate nucleation by creating a low-energy interface. The results show that the patterned nanoribbons maintain their structure and function, and successfully direct the formation of calcium phosphate with high fidelity.
Article
Chemistry, Physical
Azeem Ullah, Md Kaiser Haider, Fei-fei Wang, Shu Morita, Davood Kharaghani, Yan Ge, Yuji Yoshiko, Jung Soon Lee, Ick Soo Kim
Summary: Clay-based bone tissue scaffolds are promising materials for bone tissue engineering due to their ability to enhance osteoblastic differentiation and apatite deposition. The addition of illite clay improves the mechanical properties and biomineralization of the composite scaffolds, leading to better cell viability and osteoblastic differentiation compared to traditional scaffolds.
APPLIED CLAY SCIENCE
(2022)
Article
Materials Science, Biomaterials
Fengxiong Luo, Ling Wang, Zhanwen Xiao, Xiangdong Zhu, Yujiang Fan, Kefeng Wang, Xingdong Zhang
Summary: This study demonstrated that femtosecond laser microfabrication can enhance the hydrophilicity, surface energy, and active site contents of titanium surfaces, resulting in improved ability to induce apatite deposition. Compared to traditional methods, femtosecond laser treatment showed better bioactivity and osteointegration potential, offering a more efficient and controllable scheme for titanium bioactivation.
JOURNAL OF MATERIALS CHEMISTRY B
(2021)
Article
Biochemistry & Molecular Biology
Monika Furko, Zsolt E. Horvath, Otto Czompoly, Katalin Balazsi, Csaba Balazsi
Summary: Nanocrystalline calcium phosphate bioceramic coatings and their combination with biopolymers are innovative resorbable coatings that enhance the integration of metallic implants with the human body.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Ouassef Nahi, Alexander N. Kulak, Shuheng Zhang, Xuefeng He, Zabeada Aslam, Martha A. Ilett, Ian J. Ford, Robert Darkins, Fiona C. Meldrum
Summary: This study demonstrates the remarkable control ability of cationic polyamines over the crystallization of calcium carbonate, promoting nucleation of aragonite at low concentrations and inhibiting its growth at high concentrations. The results reveal a mechanism of interaction between polyamines and magnesium ions that allows unprecedented control over aragonite formation.
Article
Biochemistry & Molecular Biology
Ayako Oyane, Ikuko Sakamaki, Maki Nakamura, Kenji Koga, Kanako Shitomi, Saori Tanaka, Hirofumi Miyaji
Summary: The study developed a technique for forming fluoridated apatite coating on teeth, showing antibacterial activity and vertically oriented pillar-like nanocrystal structure. The technology holds promise as a tool for tooth surface functionalization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Materials Science, Multidisciplinary
Taishi Yokoi, Akiyoshi Mio, Jin Nakamura, Ayae Sugawara-Narutaki, Masakazu Kawashita, Chikara Ohtsuki
Summary: This study investigated the behavior of a new type of ceramic biomaterial, bioresponsive ceramics, composed of a salt of calcium ions and phosphate esters. The findings revealed that these materials can transform into hydroxyapatite, a potential treatment for bone defects, in a specific body fluid. The size of the phosphate ester alkyl groups affected the transformation rate.
SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
(2022)
Article
Chemistry, Multidisciplinary
Bin Jiang, Xin Li, Bozhi Yang, Shujie Yang, Xinyi Chen, Junhong Chen, Minghao Fang, Zhaohui Huang, Xin Min, Xiaozhi Hu
Summary: The occurrence of fractures is a common injury, and bone reconstruction surgery often uses porous hydroxyapatite materials. This study investigates the formation of apatite crystals within the internal microstructures of the bone implants and reveals differences in properties compared to surface-formed crystals. The findings provide insights into the temporal evolution of biomineralization processes and can contribute to the development of biomimetic implants for tissue engineering applications.
APPLIED SCIENCES-BASEL
(2023)
Article
Materials Science, Ceramics
S. Rempel, A. A. Valeeva, A. A. Rempel
Summary: In this study, the bioresorbability of TiOy/HAp nanocomposites was determined using simulated body fluid. The addition of TiOy increased the solubility of the nanocomposites and slowed down secondary crystallization in the simulated body fluid. By varying the concentration of TiOy, the degradation rate, mechanical destruction, and tube formation of the nanocomposites could be controlled.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Sudipta, Sarita Mishra, Sevi Murugavel
Summary: Ternary SiO2-CaO-P2O5 MBGs synthesized using acid assisted sol-gel process exhibit excellent bioactivity and multifunctional properties, providing potential applications in tissue regeneration, tumor suppression, antimicrobial activity and angiogenesis promotion for bone defect treatment.
JOURNAL OF NON-CRYSTALLINE SOLIDS
(2022)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)