Journal
RESPIRATORY PHYSIOLOGY & NEUROBIOLOGY
Volume 205, Issue -, Pages 16-20Publisher
ELSEVIER
DOI: 10.1016/j.resp.2014.09.008
Keywords
Alveolar recruitment; Pressure-volume curve; ARDS
Categories
Ask authors/readers for more resources
Lung volume changes involve the recruitment of collapsed alveoli and the expansion of already opened alveoli. This study aimed to determine the alveolar recruitment function by using a mathematical model from a pressure-volume curve (P-V curve). We assumed a lung model as V-L = R(P)V(0)f(P), where R recruitment function is the fraction of recruited alveoli, V-0 is the resting lung volume at FRC of a fully recruited lung, and f(P) corresponds to the normalized compliance function of the lungs open to ventilation. Seven white rabbits were subjected to saline-lavage lung injury, and P-V curves were calculated using the slow inflation technique. We obtained the P-R curve from the P-V curve, and two curves were differently shaped after lung injury. We concluded that the recruitment function was obtained from the P-V curve and that the P-R curve estimated the recruitment and derecruitment status. (C) 2014 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available