Journal
RESEARCH IN MICROBIOLOGY
Volume 166, Issue 4, Pages 303-317Publisher
ELSEVIER
DOI: 10.1016/j.resmic.2014.10.010
Keywords
Clostridium botulinum; Botulism; Botulinum neurotoxin; Genomics; Neurotoxin gene cluster
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Funding
- BBSRC Institute Strategic Programme on Gut Health and Food Safety [BB/J004529/1]
- BBSRC [BBS/E/F/00044401] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BBS/E/F/00044401] Funding Source: researchfish
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Recent developments in whole genome sequencing have made a substantial contribution to understanding the genomes, neurotoxins and biology of Clostridium botulinum Group I (proteolytic C. botulinum) and C. botulinum Group II (non-proteolytic C. botulinum). Two different approaches are used to study genomics in these bacteria; comparative whole genome microarrays and direct comparison of complete genome DNA sequences. The properties of the different types of neurotoxin formed, and different neurotoxin gene clusters found in C. botulinum Groups I and II are explored. Specific examples of botulinum neurotoxin genes are chosen for an in-depth discussion of neurotoxin gene evolution. The most recent cases of foodborne botulism are summarised. (C) 2014 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur. This is an open access article under the CC BY license
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