Drug Repositioning for Preeclampsia Therapeutics by In Vitro Screening

Pravastatin for the Prevention of Preeclampsia in High-Risk Pregnant Women

(2016) Maged M. Costantine et al.   OBSTETRICS AND GYNECOLOGY

Sildenafil Citrate Rescues Fetal Growth in the Catechol- O -Methyl Transferase Knockout Mouse Model

(2012) Joanna L. Stanley et al.   HYPERTENSION

Resolution of high uterine artery pulsatility index and notching following sildenafil citrate treatment in a growth-restricted pregnancy

(2012) T. H. Lin et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Sildenafil citrate therapy for severe early-onset intrauterine growth restriction

(2011) P von Dadelszen et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Sildenafil citrate decreases sFlt-1 and sEng in pregnant l-NAME treated Sprague–Dawley rats

(2011) S.V. Ramesar et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Nicotine restores endothelial dysfunction caused by excess sFlt1 and sEng in an in vitro model of preeclamptic vascular endothelium: a possible therapeutic role of nicotinic acetylcholine receptor (nAChR) agonists for preeclampsia

(2010) Kazuya Mimura et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

A Phosphodiesterase-5 Inhibitor Vardenafil Enhances Angiogenesis Through a Protein Kinase G–Dependent Hypoxia-Inducible Factor-1/Vascular Endothelial Growth Factor Pathway

(2010) Makoto Sahara et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Identification of known drugs that act as inhibitors of NF-κB signaling and their mechanism of action

(2010) Susanne C. Miller et al.   BIOCHEMICAL PHARMACOLOGY

A Repurposing Strategy Identifies Novel Synergistic Inhibitors ofPlasmodium falciparumHeat Shock Protein 90

(2010) Dea Shahinas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pre-eclampsia

(2010) Eric AP Steegers et al.   LANCET

Pravastatin induces placental growth factor (PGF) and ameliorates preeclampsia in a mouse model

(2010) K. Kumasawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Randomised, Double-Blinded, Placebo-Controlled Study of the Phosphodiesterase Type 5 Inhibitor Sildenafil for the Treatment of Preeclampsia

(2009) Rebekah A. Samangaya et al.   HYPERTENSION IN PREGNANCY

Predicting new molecular targets for known drugs

(2009) Michael J. Keiser et al.   NATURE

Lessons from 60 years of pharmaceutical innovation

(2009) Bernard Munos   NATURE REVIEWS DRUG DISCOVERY

Tobacco and pregnancy

(2009) John M. Rogers   REPRODUCTIVE TOXICOLOGY

Market Failure and the Poverty of New Drugs in Maternal Health

(2008) Nicholas M Fisk et al.   PLOS MEDICINE