Article
Obstetrics & Gynecology
K. Mackova, A. M. Mazzer, M. G. M. C. Mori Da Cunha, L. Hajkova Hympanova, I Urbankova, A. W. Kastelein, E. Vodegel, K. Vander Linden, H. Fehervary, Z. Guler, J. P. Roovers, L. Krofta, J. Verhaeghe, J. Deprest
Summary: The study found that non-ablative erbium-doped:yttrium-aluminium-garnet (Er:YAG) laser has a comparable effect to sham manipulation on vaginal atrophy in menopausal ewes, but is less effective than estrogen replacement therapy.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2021)
Review
Immunology
Suriya Rehman, Vijaya Ravinayagam, Insha Nahvi, Hanan Aldossary, Maha Al-Shammari, Mai Saad Al Amiri, Uday Kishore, Ebtesam A. A. Al-Suhaimi
Summary: This study discusses the significant impact of gender on morbidity and mortality of COVID-19, with factors such as innate immune response, estrogen, and microbiota potentially contributing to gender differences. It also highlights certain factors that give women greater resistance to SARS-CoV-2 infection and disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sarah Rudzinskas, Jessica F. Hoffman, Pedro Martinez, David R. Rubinow, Peter J. Schmidt, David Goldman
Summary: The study found that women with PMD are more sensitive to changes in E2 at the cellular level, leading to differential behavioral responses. Transcriptome analysis revealed significant differences in gene expression in PMD patients in all experimental conditions, suggesting that CXCL10 and CYP7B1 may serve as biomarkers and molecular targets for intervention in PMD.
MOLECULAR PSYCHIATRY
(2021)
Review
Immunology
Thomas Plante-Bordeneuve, Charles Pilette, Antoine Froidure
Summary: The interaction between lung epithelium and the immune system plays a crucial role in the pathogenesis of idiopathic pulmonary fibrosis (IPF). Pathways such as DAMPs-PAMPs are highlighted as potential mechanisms involved in disease progression.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Ophthalmology
Archana Boga, Fiona Stapleton, Michael Chapman, Blanka Golebiowski
Summary: This study examined changes in dry eye symptoms and tear film alterations during in vitro fertilisation (IVF) treatment, and their relationship with sex hormones. The results showed that IVF treatment resulted in worsened dry eye symptoms and decreased tear secretion, but these changes were not clinically significant. The relationship between sex hormone levels and dry eye symptoms was also not significant.
Article
Immunology
Yosef Tsegaye, Wasihun Admassu, Abebe Edao, Samuel Kinde, Meaza Gentu, Markos Negash, Tadelo Wondmagegn, Addisu Gize, Martha Zewdie, Kidist Bobosha, Liya Wassie
Summary: Effective control of Mycobacterium tuberculosis infection involves both the endocrine and immune system. Profiling hormones and antibodies in different stages of TB provides insight in the pathogenesis of the disease. The levels of these biomarkers significantly vary across the spectrum of TB illness, suggesting their key roles in TB pathogenesis and potential as effective biomarkers for TB treatment monitoring or diagnostics.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Christophe Caneparo, David Brownell, Stephane Chabaud, Stephane Bolduc
Summary: Tissue engineering aims to produce 3D tissues by creating scaffolds and seeding cells to mimic interactions between tissues and cells. Urology and gynaecology fields face challenges of insufficient treatment options, requiring more representative research models based on human anatomy.
BIOENGINEERING-BASEL
(2021)
Article
Biochemistry & Molecular Biology
Qi-Xin Xu, Manoj Madhavan, Shu-Wen Wei, Wang-Qing Zhang, Lei Lu, Ke-Zhi Wang, Moldovan Genna, Yong Song, Yu Zhao, Huan-Ting Shao, Jin-Wen Kang, Asgerally T. Fazleabas, Ripla Arora, Ren-Wei Su
Summary: In mammals, the endometrium undergoes dynamic changes in response to estrogen and progesterone to prepare for blastocyst implantation. Notch1 signaling over-activation in the endometrial epithelium caused dysfunction of the epithelium during the estrous cycle, resulting in hyper-proliferation and infertility. Over-activation of Notch1 signaling increased the proliferative potential of both luminal and glandular epithelial cells and disrupted their differentiation, suggesting the important roles of Notch1 signaling in regulating hormone response and differentiation of endometrial epithelial cells.
Article
Immunology
Philipp Grubwieser, Alexander Hoffmann, Richard Hilbe, Markus Seifert, Thomas Sonnweber, Nina Boeck, Igor Theurl, Guenter Weiss, Manfred Nairz
Summary: The study found that human AECII-like cells exhibit pathogen-specific innate immune functions and adapt their iron handling in response to infection. The regulation of iron transporters depends on the mode and location of the pathogen, aiming to limit bacterial iron availability.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Victoria Peer, Khitam Muhsen, Moshe Betser, Manfred S. Green
Summary: Pregnant women have lower immune response to pertussis vaccination compared to non-pregnant women, possibly due to higher levels of hormones during pregnancy. Sex hormones during pregnancy, such as progesterone and estrogen, are negatively associated with anti-pertussis toxin antibody levels.
Article
Physiology
Sebastian L. Johnston, David L. Goldblatt, Scott E. Evans, Michael J. Tuvim, Burton F. Dickey
Summary: Airway epithelial cells sense and respond defensively to pathogens, with specificity for different pathogen classes. Type 1 immune responses target intracellular pathogens like viruses, while Type 2 responses target helminths and fungi, and Type 3 responses target extracellular microbial pathogens. These responses involve changes in gene expression, release of cytokines, and induction of immune responses to resist infection.
FRONTIERS IN PHYSIOLOGY
(2021)
Review
Endocrinology & Metabolism
Jiahui Liu, Zhe Liu, Weixia Sun, Ling Luo, Xingna An, Dehai Yu, Wanning Wang
Summary: Diabetic nephropathy is a common complication in diabetes, and current treatments mainly focus on glucose and blood pressure control. However, new drugs targeting the pathological mechanisms of DN have emerged, and there is growing attention on therapeutic strategies targeting these mechanisms. Sex hormones, such as testosterone and estrogen, are believed to play important roles in the onset and progression of DN, but the underlying molecular mechanism is not fully understood. This review aims to summarize the correlation between sex hormones and DN and evaluate the potential value of hormonotherapy in DN.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Oncology
Alfred T. Harding, Nicholas S. Heaton
Summary: Microbial infections have a significant impact on human health, and the host immune response plays a crucial role in determining the outcome. It is now widely accepted that estrogens can dramatically alter the response of host cells to microbes. Understanding how estrogens change the host immune response is important for effective treatment of infected individuals.
Article
Endocrinology & Metabolism
Emily A. McGlade, Kalli K. Stephens, Sarayut Winuthayanon, Prashanth Anamthathmakula, Michael J. Holtzman, Wipawee Winuthayanon
Summary: In this study, the role of estrogen in the transcriptional regulation of ciliated epithelial cells in the oviduct was assessed using single-cell RNA-sequencing analysis. The results showed that estrogen had little impact on the gene expression profile of these cells. Additionally, conditional deletion of Esr1 from ciliated epithelial cells did not affect fertility or cilia formation in mice. Therefore, ESR1 expression in ciliated cells of the oviduct is dispensable for ciliogenesis and nonessential for female fertility.
Article
Endocrinology & Metabolism
Mette Hansen Viuff, Jesper Just, Sara Brun, Tine Vrist Dam, Mette Hansen, Lars Melgaard, David M. Hougaard, Michael Lappe, Claus Hojbjerg Gravholt
Summary: This study examined the sex hormone levels in women with Turner syndrome and the impact of hormone replacement therapy on these levels.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
