Review
Medicine, Research & Experimental
Hui-Hui Shen, Tao Zhang, Hui-Li Yang, Zhen-Zhen Lai, Wen-Jie Zhou, Jie Mei, Jia-Wei Shi, Rui Zhu, Feng-Yuan Xu, Jin Li, Jiang-Feng Ye, Ming-Qing Li
Summary: Menstruation is a cyclic physiological phenomenon controlled by ovarian hormones, and a proper understanding of normal endometrial physiology is crucial for regulating menstrual disorders. Autophagy in the endometrium, regulated by ovarian hormones, plays a key role in immune cell infiltration, tissue repair, and infection prevention during menstruation. Abnormal autophagy levels and dysregulated immune system function are associated with the pathogenesis and progression of endometriosis, suggesting the potential value of autophagy as a target for the treatment of menstrual-related and endometrium-related disorders.
Article
Biochemistry & Molecular Biology
Hong Im Kim, Tae Hoon Kim, Jung-Yoon Yoo, Steven L. Young, Bruce A. Lessey, Bon Jeong Ku, Jae-Wook Jeong
Summary: The study revealed that ARID1A levels were reduced in the endometrium of women with endometriosis, and there was a physical interaction between ARID1A and PGR, which may play a crucial role in the receptivity of the endometrium and progesterone resistance in endometriosis-related infertility.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Obstetrics & Gynecology
Rohan R. Chodankar, Alison Murray, Moira Nicol, H. R. Whitaker, Alistair R. W. Williams, Hilary O. D. Critchley
Summary: This study investigated the impact of the progesterone receptor modulator ulipristal acetate (UPA) on endometrial morphology and function. The results showed that the effects on hormone receptors, cell proliferation, and progesterone-regulated genes were reversible after cessation of treatment.
FERTILITY AND STERILITY
(2021)
Article
Developmental Biology
S. Marla, S. Mortlock, S. Houshdaran, J. Fung, B. McKinnon, S. J. Holdsworth-Carson, J. E. Girling, P. A. W. Rogers, L. C. Giudice, G. W. Montgomery
Summary: The study found that genetic regulation of genes in the ESR1 region is associated with endometriosis risk, with gene expression influenced more significantly by hormone concentrations and receptor expression. Due to limited sample size and cellular heterogeneity, the study also noted that detecting genetic effects on gene expression may be challenging.
MOLECULAR HUMAN REPRODUCTION
(2021)
Review
Biochemistry & Molecular Biology
Ping Zhang, Guoyun Wang
Summary: Endometriosis is a disease where endometrial-like tissue grows outside the uterus. Progestins are the most commonly used treatment, but some patients show resistance to these drugs. The mechanisms of this progesterone resistance include abnormal PGR signaling, chronic inflammation, aberrant gene expression, epigenetic alterations, and environmental toxins. Understanding these mechanisms may help develop new therapeutic regimens to reverse progesterone resistance in endometriosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Sylvia C. Hewitt, San-Pin Wu, Tianyuan Wang, Steven L. Young, Thomas E. Spencer, Francesco J. DeMayo
Summary: The study demonstrates that uterine cells respond to estrogen and progesterone through their nuclear receptors ESR1 and PGR, with the involvement of chromatin structures. The organoids model provides insights into the regulatory mechanisms of hormone responsiveness.
Review
Cell Biology
Ezekiel Mecha, Roselydiah Makunja, Jane B. Maoga, Agnes N. Mwaura, Muhammad A. Riaz, Charles O. A. Omwandho, Ivo Meinhold-Heerlein, Lutz Konrad
Summary: Thoracic endometriosis (TE) is a rare form of endometriosis where endometrial tissue is found in or around the lungs, often presenting as catamenial pneumothorax (CP). Immunohistochemical evaluation is considered crucial for diagnosing and classifying the disease effectively.
Article
Cell Biology
Warren B. Nothnick
Summary: Endometriosis is a significant disease characterized by infertility and pelvic pain. Altered responsiveness to progesterone, potentially regulated by miRNAs, may contribute to the pathophysiology of the disease.
Article
Endocrinology & Metabolism
Stefania Salsano, Roberto Gonzalez-Martin, Alicia Quinonero, Silvia Perez-Deben, Francisco Dominguez
Summary: This study found that PGRMC1 inhibition during decidualization in endometrial stromal cells does not interfere with cytoskeletal rearrangements and prolactin secretion, but does affect the expression of genes related to metabolism, transport, and hormonal biosynthesis. Additionally, activation of membrane progesterone receptor signaling alone is insufficient to induce proper decidualization.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cell Biology
James A. MacLean II, Kanako Hayashi
Summary: This article discusses the importance of estrogen and progesterone in maintaining a normal menstrual cycle and supporting successful pregnancy, as well as the consequences of their imbalance in gynecological diseases. The review highlights the association between dysregulated steroid hormones and chronic conditions that significantly impact women's lives.
Article
Obstetrics & Gynecology
Kashmira Bane, Junita Desouza, Diksha Shetty, Prakash Choudhary, Shalaka Kadam, R. R. Katkam, Gwendolyn Fernandes, Raj Sawant, Uddhavraj Dudhedia, Neeta Warty, Anahita Chauhan, Uddhav Chaudhari, Rahul Gajbhiye, Geetanjali Sachdeva
Summary: The study indicates that the DNA damage response is dysregulated in the eutopic endometrium of women with endometriosis, with higher expression of DDR genes compared to those without the disease. Additionally, DNA repair genes are also up-regulated in the eutopic endometrium of women with endometriosis.
HUMAN REPRODUCTION
(2021)
Article
Medicine, General & Internal
Anna C. Loeffelmann, Alena Hoerscher, Muhammad A. Riaz, Felix Zeppernick, Ivo Meinhold-Heerlein, Lutz Konrad
Summary: In endometriosis, the localization of claudin-10 is impaired, but the epithelial phenotype remains preserved. Claudin-10 is highly expressed in endometriosis and adenomyosis, but there are differences in its localization between the two conditions.
Review
Biochemistry & Molecular Biology
Jose Lourenco Reis, Natacha Nurdine Rosa, Miguel Angelo-Dias, Catarina Martins, Luis Miguel Borrego, Jorge Lima
Summary: Endometriosis is a chronic inflammatory disorder characterized by the presence of endometrial cells outside the uterus. Studies indicate a correlation between the immune system, particularly NK receptors (NKR), and endometriosis, suggesting their essential role in the disease's pathogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yuri Park, Sang Jun Han
Summary: Endometriosis is an estrogen-dependent inflammatory disease that causes pelvic pain and infertility in women. Immune system defects may contribute to the progression of endometriosis. Elevated levels of interferon, a cytokine, play a crucial role in endometriosis progression, but also have a critical role in normal endometrial function, particularly in pregnancy initiation and maintenance.
Review
Oncology
Nozomi Yachida, Kosuke Yoshihara, Manako Yamaguchi, Kazuaki Suda, Ryo Tamura, Takayuki Enomoto
Summary: Driver gene mutations have been identified in both endometriosis and normal endometrium, potentially leading to endometriosis-associated ovarian cancer. Despite the continuum of genomic alterations, the molecular mechanism of ovarian carcinogenesis from the normal endometrium through endometriosis remains unclear.
Article
Obstetrics & Gynecology
Sukainah Alfaraj, Heather Noga, Catherine Allaire, Christina Williams, Sarka Lisonkova, Paul J. Yong, Mohamed A. Bedaiwy
Summary: The study aimed to investigate the practicality of using ultrasound data to predict a low EFI score, showing that a negative sliding sign and EFI historic factors score were able to predict an EFI score <= 6 successfully.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Article
Obstetrics & Gynecology
Paul J. Yong, Mohamed A. Bedaiwy, Fahad Alotaibi, Michael S. Anglesio
Summary: The pathogenesis of bowel endometriosis is multifactorial and involves factors such as reflux of endometrium, uterine attachment rupture and fibrosis, oxidative stress, microbiome, neurogenesis, nerve fiber recruitment, and genetic mutations. Bowel endometriosis may be classified based on molecular features in the future.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2021)
Article
Anesthesiology
Natasha L. Orr, Kate J. Wahl, Michelle Lisonek, Angela Joannou, Heather Noga, Arianne Albert, Mohamed A. Bedaiwy, Christina Williams, Catherine Allaire, Paul J. Yong
Summary: This study explored the concept of using a CSI cutoff of 40 to identify patients with endometriosis who have pain associated with central nervous system sensitization. A significant correlation was found between the number of central sensitivity syndromes (CSS) and pain scores, as well as the CSI score. A CSI cutoff of 40 demonstrated high sensitivity and specificity in identifying patients with >= 3 CSS, suggesting its potential as a practical tool in clinical settings.
Editorial Material
Obstetrics & Gynecology
Mohamed A. Bedaiwy
FERTILITY AND STERILITY
(2022)
Article
Developmental Biology
Jefferson Terry, Mohamed A. Bedaiwy
Summary: This study uses digital spatial profiling to assess the pathogenetic mechanism of CIUE and reveals a specific profile of inflammatory mediators dominated by IFN signaling.
Article
Obstetrics & Gynecology
Bahi Elbasueny, Maya Geerts, Catherine Allaire, Paul J. Yong, Mohamed A. Bedaiwy
Summary: Adenomyosis is a common gynecological disease with unclear pathogenesis, presenting mainly with painful symptoms, bleeding, and infertility. Current treatment approaches focus on symptom relief, while research is ongoing to explore new therapeutic options targeting the underlying mechanisms of the disease. Various alternative modalities exist for adenomyosis management, but definitive therapy remains hysterectomy.
CURRENT OBSTETRICS AND GYNECOLOGY REPORTS
(2022)
Article
Obstetrics & Gynecology
Ruth Habte, Ali Yosef, Mohamed Bedaiwy
Summary: Medical management is effective in completely or partially resolving uterine AVMs. Subsequent pregnancies in this population are feasible and are not at higher risk for perinatal complications.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Review
Health Care Sciences & Services
Brintha Sivajohan, Mohamed Elgendi, Carlo Menon, Catherine Allaire, Paul Yong, Mohamed A. Bedaiwy
Summary: This review explores the use of AI methods to address clinical problems in endometriosis and finds that AI models have good diagnostic and predictive capacity, offering promising directions for assessing endometriosis.
NPJ DIGITAL MEDICINE
(2022)
Article
Obstetrics & Gynecology
Sophie Jansen, Genevieve Leduc-Robert, Faten F. AbdelHafez, Arianne Albert, Ulrike Mayer, Mohamed A. Bedaiwy
Summary: This study, conducted through a retrospective chart review, found that thyroperoxidase antibody positivity does not significantly impact thyroid stimulating hormone levels during pregnancies. However, treatment with levothyroxine in patients with subclinical hypothyroidism can increase the live birth rate.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2022)
Article
Public, Environmental & Occupational Health
Sarka Lisonkova, Jeffrey N. Bone, Giulia M. Muraca, Neda Razaz, Amelie Boutin, Justin S. Brandt, Mohamed A. Bedaiwy, Cande Ananth, K. S. Joseph
Summary: The closure of ART clinics during the early pandemic resulted in a significant decline in ART-conceived live births and multiple births, as well as an increase in stillbirths among ART-conceived births. Women who conceived during the early pandemic period also had a higher prevalence of obesity and chronic hypertension.
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Pediatrics
Sarka Lisonkova, Ugochinyere Vivian Ukah, Sid John, Lauren Yearwood, Giulia M. Muraca, Neda Razaz, Yasser Sabr, Paul J. Yong, Mohamed A. Bedaiwy
Summary: The study found that the disparities in adverse perinatal outcomes between women who used medically assisted reproduction (MAR) and those who conceived spontaneously were larger in terms of race and ethnicity.
Article
Obstetrics & Gynecology
Mohamed A. Bedaiwy, Bahi Fayek, Emily C. Yang, Mahmoud S. Iews, Mohamed Elgendi, Amr O. Abdelkareem, Ahmed H. Abdellah, Yang Doris Liu, Adrian Jones, Ulrike Mayer, Faten F. Abdel Hafez
Summary: This study examined the impact of non-visualized pregnancy loss (NVPL) on future reproductive outcomes in patients with recurrent pregnancy loss (RPL). The results showed that the number of previous NVPLs is a significant predictor of subsequent live birth.
HUMAN REPRODUCTION
(2023)
Letter
Public, Environmental & Occupational Health
Sarka Lisonkova, Jeffrey N. N. Bone, Giulia M. M. Muraca, Neda Razaz, Amelie Boutin, Justin S. S. Brandt, Mohamed A. A. Bedaiwy, Cande V. V. Ananth, K. S. Joseph
PAEDIATRIC AND PERINATAL EPIDEMIOLOGY
(2023)
Article
Obstetrics & Gynecology
Ann Korkidakis, Arianne Y. Albert, Irene Jiang, Jefferson Terry, Faten F. AbdelHafez, Mohamed A. Bedaiwy
Summary: The study aimed to investigate the relationship between embryonic chromosomal errors in products of conception (POC) and maternal age, gestational age (GA) of pregnancy loss, and findings on routine recurrent pregnancy loss (RPL) workup. A retrospective cohort study of women with a history of >= 2 pregnancy losses was conducted, analyzing 1107 miscarriages from 741 women who underwent cytogenetic testing. The results showed a linear relationship between embryonic chromosomal errors and maternal age, as well as GA of pregnancy loss. Women with positive findings on routine RPL workup had lower odds of chromosomal errors. The study suggests that primary cytogenetic testing on POCs should be offered to all RPL patients.
REPRODUCTIVE SCIENCES
(2023)
Article
Medicine, General & Internal
Natasha L. Orr, Alice J. Huang, Yang Doris Liu, Heather Noga, Mohamed A. Bedaiwy, Christina Williams, Catherine Allaire, Paul J. Yong
Summary: This study aimed to examine the association between baseline Central Sensitization Inventory scores and postsurgical pain outcomes in patients with endometriosis. The results showed that higher Central Sensitization Inventory scores were significantly associated with worse chronic pelvic pain, deep dyspareunia, dyschezia, and back pain at follow-up.
