Article
Agriculture, Dairy & Animal Science
Sarah R. McCoski, Rebecca R. Cockrum, Alan D. Ealy
Summary: Exposure to maternal obesity during pregnancy can have significant effects on offspring development, which may not be apparent until adulthood. This study investigated how obesity influences gene expression in the endometrium during early pregnancy using a sheep model. The results showed that obesity affects gene expression related to the immune response, adhesion, and angiogenesis in the endometrium. These findings suggest that the peri-implantation endometrium is responsive to maternal obesity and changes in gene expression during early embryogenesis may contribute to developmental programming.
JOURNAL OF ANIMAL SCIENCE
(2022)
Review
Obstetrics & Gynecology
Awoniyi O. Awonuga, Olivia G. Camp, Husam M. Abu-Soud, Daniel A. Rappolee, Elizabeth E. Puscheck, Michael P. Diamond
Summary: The contributions of uterine endometrium and embryo in implantation success are still debated. Various measures, such as endometrial receptivity analysis (ERA), endometrial scratch (ES), endometrial microbiome, and intrauterine or intravenous measures, are recommended to improve implantation success. However, there is insufficient evidence to determine the relative importance of endometrium and embryo in implantation success and the utility of these measures, especially with euploid embryos. Evidence suggests that embryos can implant and develop on non-endometrium epithelium. The role of embryo euploidy in implantation success is currently underappreciated.
REPRODUCTIVE SCIENCES
(2023)
Article
Reproductive Biology
Mehmet Kose, Mustafa Hitit, Mehmet Salih Kaya, Mesut Kirbas, Sukru Dursun, Ilyas Alak, Mehmet Osman Atli
Summary: This study aimed to elucidate the expression pattern of miRNAs in the endometrium during peri-implantation in ewes. A total of 116 ovine-specific miRNAs were detected, with 19 differentially expressed in early pregnancy. The differentially expressed miRNAs targeted a total of 315 genes, with functional enrichment in the innate immune system and signaling pathways.
Article
Obstetrics & Gynecology
Genia Rozen, Peter Rogers, Wan Tinn Teh, Catharyn J. Stern, Alex Polyakov
Summary: RIF is a disorder with an imprecise definition lacking robust scientific basis, presenting significant challenges in diagnosis and treatment. The concept of 'Theoretical Cumulative Implantation Rate' is proposed to determine RIF diagnosis based on objective data. An updated and standardized definition is needed for patient counseling and research planning.
HUMAN REPRODUCTION
(2021)
Article
Biochemistry & Molecular Biology
Yuta Matsuno, Kazuya Kusama, Kazuhiko Imakawa
Summary: This study characterized the expression profile of lncRNAs during peri-implantation periods in sheep conceptuses. The analysis identified a total of 8808 lncRNAs, including 3423 novel lncRNAs. Gene ontology analysis revealed enrichment of lncRNA target genes in the respiratory electron transport chain (RETC). The findings suggest that lncRNAs may play a role in regulating RETC during conceptus development in sheep.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Endocrinology & Metabolism
Davoud Jafari-Gharabaghlou, Mostafa Vaghari-Tabari, Hajar Oghbaei, Laura Lotz, Reza Zarezadeh, Yeganeh Rastgar Rezaei, Mahnaz Ranjkesh, Mohammad Nouri, Amir Fattahi, Saba Nikanfar, Ralf Dittrich
Summary: This review highlights the role of various adipokines in embryo-maternal interactions, endometrial receptivity, and embryo implantation, as well as the underlying molecular mechanisms.
ENDOCRINE CONNECTIONS
(2021)
Article
Multidisciplinary Sciences
Rong Li, Xiaoqiu Wang, Zhenyao Huang, Jayani Balaji, Tae Hoon Kim, Tianyuan Wang, Lecong Zhou, Ashley Deleon, Molly E. Cook, Margeaux W. Marbrey, San-Pin Wu, Jae Wook Jeong, Ripla Arora, Francesco J. DeMayo
Summary: The loss of uterine epithelial progesterone receptor (PGR) is crucial for embryo implantation in both humans and mice. This study reveals that the two major isoforms PGRA and PGRB disrupt embryo implantation through FOXO1 pathways in uterine epithelium, and both regulate the LIF-SGK1-FOXO1 signaling pathway.
Article
Biochemistry & Molecular Biology
Kanako Takimoto, Hideto Yamada, Shigeki Shimada, Yoshiyuki Fukushi, Shinichiro Wada
Summary: The aim of this study was to evaluate the association between chronic endometritis and uterine endometrium microbiota with repeated implantation failures and recurrent pregnancy losses. The results suggest that chronic endometritis may be involved in the pathophysiology of recurrent pregnancy losses and repeated implantation failures. Lactobacillus iners and Ureaplasma species may be associated with the etiology of chronic endometritis.
Review
Immunology
Nupur Mukherjee, Richa Sharma, Deepak Modi
Summary: Recurrent implantation failure (RIF) can be caused by uterine factors, male factors, or embryo factors. It is associated with disrupted endometrial receptivity, altered gene expression, immunologic disturbances, and epigenetic alterations. RIF is a heterogeneous condition with varied immune responses, and personalized therapies based on the patient's immune status are being tested.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Hsien-Ming Wu, Liang-Hsuan Chen, Le-Tien Hsu, Chyong-Huey Lai
Summary: Embryo-endometrial communication plays a critical role in successful embryo implantation and pregnancy establishment through the regulation of maternal immune responses. Recent research has highlighted the importance of extracellular vesicles (EVs) and microRNAs in this process, showing that they modulate maternal immune responses and promote cross-communication between the embryo and the endometrium. Exploring the functions and mechanisms of EVs in embryo implantation and pregnancy may provide valuable insights for reproductive medicine and infertility treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Jinxiang Wu, Shu Lin, Pinxiu Huang, Lingling Qiu, Yufei Jiang, Ying Zhang, Nan Meng, Meiqing Meng, Lemeng Wang, Wenbo Deng, Zhao Liu, Chuanhui Guo, Jinhua Lu, Haibin Wang, Shuangbo Kong
Summary: Experiments on mice and analysis of human samples suggest that mental stress during early pregnancy can alter the functional status of endometrial receptivity, potentially leading to pregnancy failure. The epinephrine signaling pathway is found to play a significant role in regulating endometrial receptivity.
COMMUNICATIONS BIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Wiktoria Kozlowska, Ewa Monika Drzewiecka, Agata Zmijewska, Anna Koziorowska, Anita Franczak
Summary: This study investigated the effects of EMF on androgen synthesis and release from pig endometrium, finding that EMF may have suppressive effects on endometrial testosterone release and increased androstenedione release. Progesterone did not protect the pig endometrium against EMF radiation during the fetal peri-implantation period.
ANIMAL REPRODUCTION SCIENCE
(2021)
Editorial Material
Biology
J. Julie Kim
Summary: A new laboratory model helps to study the role of senescent cells in fostering a uterine environment that can support an embryo.
Review
Biochemistry & Molecular Biology
Annalisa Inversetti, Enrica Zambella, Alice Guarano, Marinella Dell'Avanzo, Nicoletta Di Simone
Summary: Recent studies have shown that the uterus has its own microbiota, but the composition of endometrial microbiota and its role in a healthy uterine environment are still not well understood. The interaction between endometrial microbiota and the immune system during conception and pregnancy may play a crucial role in reproductive outcomes. This review aims to summarize the molecular mechanisms by which endometrial microbiota interacts with the immune system, and discuss the link between dysbiosis and reproductive disorders.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell & Tissue Engineering
Maria Diniz-da-Costa, Chow-Seng Kong, Katherine J. Fishwick, Thomas Rawlings, Paul J. Brighton, Amelia Hawkes, Joshua Odendaal, Siobhan Quenby, Sascha Ott, Emma S. Lucas, Pavle Vrljicak, Jan J. Brosens
Summary: The study identifies a highly proliferative population of mesenchymal cells (hPMC) in midluteal human endometrium, potentially serving as novel decidual precursors; hPMC differ from endometrial stromal cells in the expression of genes for prolactin and other decidual transcription factors, and show signs of differentiation into a decidual subpopulation discovered in early pregnancy; recurrent pregnancy loss is associated with depletion of hPMC.
Article
Chemistry, Physical
He Lin, Xia Long, Yiming An, Shihe Yang
JOURNAL OF CHEMICAL PHYSICS
(2020)
Article
Chemistry, Multidisciplinary
Jun Yu, Zheng Wang, Jian Wang, Wenhua Zhong, Min Ju, Rongming Cai, Chen Qiu, Xia Long, Shihe Yang
Article
Chemistry, Multidisciplinary
Zhuwen Chen, Min Ju, Mingzi Sun, Li Jin, Rongming Cai, Zheng Wang, Lei Dong, Luming Peng, Xia Long, Bolong Huang, Shihe Yang
Summary: Efficient noble-metal free electrocatalyst for oxygen evolution reaction (OER) is crucial for large-scale hydrogen production via water splitting. By designing an electrostatic 2D-2D assembly route, researchers successfully synthesized a LDH(+)-Birnessite(-) hybrid catalyst with advanced catalytic activity and excellent stability under industrial hydrogen production conditions. Experimental and computational results show that shifting Fe-3d orbitals in LDH significantly enhances the electron transfer process during OER, leading to improved performance.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Jun Yu, Jian Wang, Xia Long, Lei Chen, Qi Cao, Jian Wang, Chen Qiu, Jongwoo Lim, Shihe Yang
Summary: This study reports a one-step synthesis of high-valence nickel-doped CeO2-x covered with FeOOH nanosheets in the presence of Ni2+/Fe3+, leading to efficient oxygen evolution reaction (OER) electrocatalysis. The etching effect on ceria by H+ species from the hydrolysis of Fe3+ was revealed through a series of experiments, promoting the formation of high-valence Ni3+/Ni4+.
ADVANCED ENERGY MATERIALS
(2021)
Article
Chemistry, Physical
Jian Wang, Se-Jun Kim, Jiapeng Liu, Yang Gao, Subin Choi, Jeongwoo Han, Hyeyoung Shin, Sugeun Jo, Juwon Kim, Francesco Ciucci, Hwiho Kim, Qingtian Li, Wanli Yang, Xia Long, Shihe Yang, Sung-Pyo Cho, Keun Hwa Chae, Min Gyu Kim, Hyungjun Kim, Jongwoo Lim
Summary: A new method of modulating catalyst surface structure was proposed, showing significant performance and stability in the oxygen evolution reaction.
Article
Nanoscience & Nanotechnology
Min Ju, Rongming Cai, Jiazheng Ren, Jinxi Chen, Limin Qi, Xia Long, Shihe Yang
Summary: This study presents a method to tune the charge transfer and sorption-desorption properties of a catalyst by intercalating a conductive polymer into a layered double hydroxide, resulting in improved catalytic performance for the oxygen evolution reaction. In situ scanning electrochemical microscopy revealed that the hybrid catalyst exhibited a higher catalytic current density at the subnanometer scale compared to the bare catalyst.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Multidisciplinary
Runni Wu, Kin Wa Kwan, He Lin, Pu Li, Xia Long, Shihe Yang, Alfonso Hing Wan Ngan
Summary: Living organisms have compact intelligence achieved through highly integrated and demodularized subunits, which can be replicated in robotics using emerging stimuli-responsive materials.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Energy & Fuels
Jiazheng Ren, Xia Long, Xiaoting Wang, Zedong Lin, Rongming Cai, Min Ju, Yongfu Qiu, Shihe Yang
Summary: This paper presents a novel synthesis strategy for Bi-based catalyst in CO2 reduction reaction (CO2RR), which successfully synthesized heterostructured Bi/Bi2O3 nanoplates with abundant O vacancies. The catalyst exhibits excellent catalytic activity for CO2RR and high selectivity for formate generation, surpassing most of the state-of-the-art Bi-based catalysts reported to date. The combination of coordination and heterointerface engineering is shown to promote the catalytic activity and selectivity of Bi-based materials for CO2RR.
Article
Chemistry, Multidisciplinary
Min Ju, Zhuwen Chen, Hong Zhu, Rongming Cai, Zedong Lin, Yanpeng Chen, Yingjie Wang, Jiali Gao, Xia Long, Shihe Yang
Summary: Non-noble metal catalyst Fe-Birnessite (Fe-Bir) was synthesized by controlled Fe-(III) intercalation- and docking-induced layer reconstruction, with significantly improved catalytic activity for the oxygen evolution reaction (OER). The Fe-Bir catalyst exhibited lower OER overpotential and Tafel slope compared to other Bir-based catalysts, and it featured active Fe-(III)-O-Mn-(III) centers interfaced with ordered water molecules between neighboring layers. This study reveals a new OER mechanism and highlights the importance of engineering the confined interlayer environment for efficient energy conversion catalysis.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Zheng Tan, Lihua Zhang, Tong Wu, Bowei Zhou, Xia Long
Summary: Efficient noble-metal-free electrocatalysts are crucial for sustainable generation of green hydrogen. In this study, the catalytic performance of transition-metal-based compounds with tuned chemical compositions was comprehensively investigated, revealing the roles of cations and anions in energy conversion reactions. The engineering of transition metal cations led to improved catalytic activity of the formed transition metal oxides toward water oxidation, while the intake of anions on the TMO surface resulted in multifunctional catalysts for urea oxidation and hydrogen evolution reactions. The constructed TMO & PAR;a-TMO/c-TMS exhibited a much lower potential for alkali hydrogen generation than the noble-metal-based system (IrO2 & PAR;Pt).
JOURNAL OF PHYSICAL CHEMISTRY C
(2023)
Review
Chemistry, Inorganic & Nuclear
Zheng Tan, Lihua Zhang, Tong Wu, Yinbo Zhan, Bowei Zhou, Yilin Dong, Xia Long
Summary: This review focuses on the applications and structure-performance relationship of organic-inorganic hybrid materials (OIHs) for electrochemical water oxidation, a new class of advanced materials with hierarchical architectures and redox characters. The general principles of water oxidation are presented, followed by the progresses on the applications of different types of OIHs. The roles of organic counterparts on catalytic active centers are discussed, and the challenges and perspectives of using this hybrid material as an electrocatalyst are provided.
Article
Chemistry, Physical
Xia Long, Lihua Zhang, Zheng Tan, Bowei Zhou
Summary: This review article provides a comprehensive overview of recent research progress on 2D-2D hybrid materials, focusing on their fabrication strategies, heterointerface characterization techniques, and applications in energy conversion reactions. The strong coupling effects resulting from large heterointerfaces and strong interactions between the two components in 2D-2D hybrids enhance the electronic structure of active sites and facilitate charge transfer during energy conversion reactions.
Article
Materials Science, Multidisciplinary
Jinxi Chen, Xiaofei Wei, Rongming Cai, Jiazheng Ren, Min Ju, Xiaoqing Lu, Xia Long, Shihe Yang
Summary: This study investigates the influence of Cu/Zn ratio on CO2RR catalysis in CuZn electrocatalyst. Zn promotes CO generation, while trace Ni inhibits H2 evolution. CuZn-Ni catalyst shows improved activity and selectivity for CO generation.
ACS MATERIALS LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Rongming Cai, Mingzi Sun, Jiazheng Ren, Min Ju, Xia Long, Bolong Huang, Shihe Yang
Summary: The study presents a hybrid catalyst synthesized through electrochemical transformation, which can effectively enhance the activity and selectivity of copper-based catalysts in the CO2 reduction reaction. By anchoring 2D-Cu metallic dots on F-doped CuxO nanoplates, the hybrid catalyst achieved high efficiency in generating CH3COO- at extremely low potentials.
Review
Chemistry, Multidisciplinary
Rongming Cai, Min Ju, Jinxi Chen, Jiazheng Ren, Jun Yu, Xia Long, Shihe Yang
Summary: This article reviews recent advances in surface/interface engineering of energy conversion catalysts, focusing on surface defect engineering, surface crystalline property modulation, surface microstructure tailoring, and heterointerface construction. The material development strategies and their impacts on catalyst performance are discussed with representative examples, along with a summary and outlook on future developments and challenges in this promising area.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Obstetrics & Gynecology
Alice Newman-Sanders, Jackson C. Kirkman-Brown, Meurig T. Gallagher
Summary: This study revealed a significant lack of awareness among young adults in the UK regarding the potential impacts of gym lifestyles and supplementation on male infertility. Men were found to have a concerning lack of concern for their own fertility, with differences in awareness levels between men and women. It was also observed that men were more likely to consider making changes to their behavior if it had a long-term impact on their fertility compared to short-term effects.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Shachar Reuvenny, Michal Youngster, Almog Luz, Rohi Hourvitz, Ettie Maman, Micha Baum, Ariel Hourvitz
Summary: Using a machine-learning model to determine the optimal trigger days can improve the outcomes of antagonist protocol cycles in freeze-all or fresh transfer cycles, for all age groups. Implementing these models can more accurately predict the number of retrieved oocytes, optimizing physicians' decisions, balancing workloads, and creating more standardized yet patient-specific protocols.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Chao Chen, Qi Wen, Feng Deng, Rong Li, Ying Wang, Xiumei Zhen, Jing Hang
Summary: This study investigates the proteomic and phosphoproteomic differences in the endometrium of women with recurrent pregnancy loss (RPL) compared to healthy control women during different phases of the menstrual cycle. The results identify differentially expressed proteins and phosphorylated proteins, and highlight the insulin/cyclic nucleotide signalling pathway and AMPK/mTOR signalling pathway as major contributors to the abnormality of RPL endometrium. The findings provide insights into potential proteins associated with the pathogenesis of RPL and contribute to the identification of potential targets for RPL treatment.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
Article
Obstetrics & Gynecology
Jaime Guerrero, Juan Carlos Castillo, Jorge Ten, Jose Antonio Ortiz, Belen Lledo, Domingo Orozco, Francisco Quereda, Andrea Bernabeu, Rafael Bernabeu
Summary: The study found no significant differences in clinical outcomes between using oocytes obtained from random-start protocols and those from conventional ovarian stimulation in oocyte donation treatments. Luteal-phase stimulation required longer stimulation and higher FSH consumption.
REPRODUCTIVE BIOMEDICINE ONLINE
(2024)
