Review
Endocrinology & Metabolism
Yamei Xue, Xiaohong Cheng, Yuping Xiong, Kun Li
Summary: This review summarizes and discusses the mutations of nine important genes associated with fertilization failure in infertile patients. The review highlights their roles in the fertilization process and suggests these mutations as potential targets for precision treatments in reproductive medicine. Furthermore, the review provides helpful clues for genetic counseling and optimizing clinical treatments for human infertility by supplying timely information on the genetic causes of fertilization failure.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Huixiao Chen, Ping Sun, Na Zhang, Shangge Lv, Yongzhi Cao, Lei Yan
Summary: This study assessed the effect of uterine septum resection on reproductive outcomes in patients with secondary infertility undergoing in vitro fertilization/intracytoplasmic sperm injection. The results showed that uterine septum resection improved the pregnancy rates and live birth rates in these patients.
FRONTIERS IN MEDICINE
(2022)
Article
Endocrinology & Metabolism
Yuqing Jiang, Zhaoyang Shen, Jianmin Xu, Jing Zhu, Huan Wang, Wenhui Chen, Yingpu Sun, Qingling Yang
Summary: High sperm DNA fragmentation index (DFI) in overweight/obese women during ICSI cycles leads to decreased fertilization, cleavage, and high-quality embryo rates. The diminished capacity of oocytes to repair sperm DNA damage may be the cause of the decreased early developmental potential in embryos from overweight/obese patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Robert John Norman
Summary: Intracytoplasmic sperm injection (ICSI) was initially introduced for male infertility but is now widely used in assisted reproduction techniques. The indications for ICSI use need to be re-evaluated to ensure appropriate application in infertility management.
FERTILITY AND STERILITY
(2022)
Review
Medicine, General & Internal
Lauren Lacey, Sibte Hassan, Sebastian Franik, Mourad W. Seif, M. Ahsan Akhtar
Summary: The effects of assisted hatching (AH) on live birth rates are uncertain and may increase the risk of multiple pregnancies. Although AH may offer a slightly increased chance of achieving a clinical pregnancy, the quality of data is low, and it is uncertain whether it influences miscarriage rates.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Endocrinology & Metabolism
Ning Huang, Lixue Chen, Ying Lian, Haining Wang, Rong Li, Jie Qiao, Hongbin Chi
Summary: The presence of thyroid autoimmunity in patients with infertility did not impair embryo quality or affect pregnancy outcomes, including clinical pregnancy, miscarriage, preterm delivery, and live birth. However, it decreased the number of oocytes retrieved and birth weight in twin pregnancy. Subgroup analysis showed no association between the types or titers of thyroid antibodies and adverse IVF/ICSI outcomes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Veterinary Sciences
Effrosyni Fatira, Milos Havelka, Taiju Saito, Jose Landeira, Marek Rodina, David Gela, Martin Psenicka
Summary: In this study, the researchers applied intracytoplasmic sperm injection (ICSI) technology to endangered sturgeons and found that it successfully produced embryos and larvae. Furthermore, molecular analysis showed genome integration of both egg and sperm donor species, demonstrating the potential of ICSI for assisted reproduction in sturgeons.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Obstetrics & Gynecology
Wen Yao, Ying Chen, Haixia Yao, Qingyun Yao, Lan Wang, Meng Wang, Jing Yue
Summary: This retrospective cohort study investigated the relationship between uterine niche and reproductive outcomes of IVF/ICSI. The study found that women with uterine niche had lower live birth rate, positive HCG test rate, clinical pregnancy rate, and implantation rate during IVF/ICSI treatment. The study highlights the negative impact of uterine niche on fertility outcomes in women with cesarean section history.
FERTILITY AND STERILITY
(2023)
Article
Endocrinology & Metabolism
Yalong Liu, Zining He, Ning Huang, Lin Zeng, Yang Wang, Rong Li, Hongbin Chi
Summary: This study aimed to investigate the impact of thyroid autoimmunity and total 25-hydroxyvitamin D concentration on early pregnancy outcomes in women undergoing in vitro fertilization/intracytoplasmic sperm injection. The study found that patients with thyroid autoimmunity had lower vitamin D serum concentrations and fewer good-quality embryos. Aging was also found to adversely affect clinical and ongoing pregnancy in this population.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Fangying Chen, Yixin Chen, Qinyun Mai
Summary: Methylation profiles in cumulus cells (CCs) were found to be associated with pregnancy outcomes in women undergoing intracytoplasmic sperm injection-in vitro fertilization (ICSI-IVF) procedures. Machine learning approaches were used to establish a prediction model, and gene set analyses and pathway analysis provided validation for the importance of methylated genes.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Ning Huang, Lin Zeng, Jie Yan, Hongbin Chi, Jie Qiao
Summary: In women undergoing IVF/ICSI treatment, a history of thyroid cancer may decrease the number of retrieved oocytes and high-grade embryos, but does not impact pregnancy outcomes or increase the risk of adverse obstetric outcomes.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Review
Medicine, General & Internal
Sandrine Chamayou, Filippo Giacone, Rossella Cannarella, Antonino Guglielmino
Summary: The intracytoplasmic sperm injection (ICSI) technique was invented to address severe male infertility caused by altered sperm parameters. It is now widely used worldwide for couple infertility treatment. ICSI can be performed using any available spermatozoon, regardless of motility, morphology, or quantity. Published data shows that ICSI accelerates zygote kinetics and leads to higher fertilization rates and more blastocysts for clinical use compared to conventional IVF. Various sperm and spermatozoa characteristics, such as parameters, morphology, vitality, DNA content, RNA content, epigenetics, and recovery site, have different impacts on fertilization, blastocyst rates, and embryo kinetics. While ICSI is the most common solution for couple infertility, understanding the causes of male infertility is crucial for producing competent spermatozoa that contribute to normal embryonic development and healthy offspring.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Reproductive Biology
Luisa Ramirez-Agamez, Camilo Hernandez-Aviles, Dickson D. Varner, Charles C. Love
Summary: This study explores stallion-associated factors in intracytoplasmic sperm injection (ICSI) using frozen/thawed sperm. The results indicate that the composition of freezing extender affects the developmental competence of sperm and in vitro-matured equine oocytes after ICSI. Furthermore, there were no significant differences observed when using ejaculated or epididymal sperm, or sperm with different morphological features in ICSI outcomes.
Article
Obstetrics & Gynecology
Qingxia Meng, Yunyu Xu, Aiyan Zheng, Hong Li, Jie Ding, Yongle Xu, Yan Pu, Wei Wang, Huihua Wu
Summary: This prospective randomized controlled trial aimed to compare the effectiveness of time-lapse monitoring (TLM) and conventional morphological assessment (CMA) for embryo selection. The results showed that the clinical pregnancy rate (CPR) and live birth rate (LBR) were significantly lower in the TLM group compared to the CMA group. However, there was no significant difference in CPR between the TLM and CMA groups for fresh embryo transfer or FET.
FERTILITY AND STERILITY
(2022)
Review
Endocrinology & Metabolism
Hanglin Wu, Songying Zhang, Xiaona Lin, Shasha Wang, Ping Zhou
Summary: The study found that delays in progesterone supplementation until 96 hours after oocyte retrieval did not affect pregnancy outcomes. The combination of progesterone and gonadotropin-releasing hormone agonists showed significant benefits for live birth. Comparisons between active LPS treatments showed small and uncertain differences in efficacy and tolerability.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2021)
Article
Obstetrics & Gynecology
Yanhe Liu, Katie Feenan, Vincent Chapple, Peter Roberts, Phillip Matson
Article
Obstetrics & Gynecology
Yanhe Liu, Katie Feenan, Vincent Chapple, Phillip Matson
Editorial Material
Obstetrics & Gynecology
Yanhe Liu, Denny Sakkas, Masoud Afnan, Phillip Matson
Review
Genetics & Heredity
Yanhe Liu, Fang Qi, Phillip Matson, Dean E. Morbeck, Ben W. Mol, Sai Zhao, Masoud Afnan
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2020)
Article
Genetics & Heredity
Kate Watson, Irving Korman, Yanhe Liu, Deirdre Zander-Fox
Summary: Live birth can be achieved in patients with zona production deficiency. Adjustments in ovarian stimulation and subsequent embryo culture strategies may have contributed to the success of the third cycle.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2021)
Review
Obstetrics & Gynecology
James M. Kemper, Yanhe Liu, Masoud Afnan, Elizabeth R. Hammond, Dean E. Morbeck, Ben W. J. Mol
Summary: Embryo quality is crucial for the success of IVF, with low-grade blastocysts (LGB) not receiving enough attention in existing scoring systems. Studies show that LGB have similar euploidy and pregnancy success rates after implantation, with no adverse effects on pregnancy or perinatal outcomes. Evidence for pregnancy outcomes is lacking for different grades of LGB, with most studies comparing all LGB as one category with optimal blastocysts.
REPRODUCTIVE BIOMEDICINE ONLINE
(2021)
Article
Genetics & Heredity
Lee-Sarose Orevich, Kate Watson, Kee Ong, Irving Korman, Ross Turner, David Shaker, Yanhe Liu
Summary: This study examined the morphometric and morphokinetic features of male and female pronuclei (PN) in human zygotes. The results showed that male and female zygotes had different time intervals and size differences in PN appearance. Male zygotes also had a higher rate of central PN juxtaposition compared to female zygotes. These findings suggest that embryo selection based on these parameters may result in an unbalanced sex ratio in offspring.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Editorial Material
Obstetrics & Gynecology
Masoud Afnan, Michael Anis Mihdi Afnan, Yanhe Liu, Julian Savulescu, Abhishek Mishra, Vincent Conitzer, Cynthia Rudin
Summary: The past decade has witnessed a rapid growth of machine learning applications in healthcare, but the premature implementation of these algorithms has led to mixed and sometimes negative outcomes. This paper emphasizes the critical need for "data solidarity" in machine learning for embryo selection, which involves ensuring individual rights, promoting data justice and equity, and utilizing data for the public good.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Haowen Zou, James M. Kemper, Elizabeth R. Hammond, Fengqin Xu, Gensheng Liu, Lintao Xue, Xiaohong Bai, Hongqing Liao, Songguo Xue, Shuqin Zhao, Lan Xia, Jean Scott, Vincent Chapple, Masoud Afnan, Dean E. Morbeck, Ben W. J. Mol, Yanhe Liu, Rui Wang
Summary: The transfer of single low-grade blastocysts resulted in a reduced live birth rate compared to single good-grade blastocysts, but did not lead to more adverse perinatal outcomes.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
Kate Bickendorf, Fang Qi, Kelli Peirce, Jay Natalwala, Vincent Chapple, Yanhe Liu
Summary: Spontaneous collapse (SC) of human blastocysts is associated with reduced euploid embryo and pregnancy rates in IVF treatment.
HUMAN REPRODUCTION
(2023)
Review
Obstetrics & Gynecology
James M. Kemper, Yanhe Liu, Masoud Afnan, Ben W. J. Mol, Dean E. Morbeck
Summary: There is a lack of evidence on embryos derived from oocytes without two pronuclei (2PN) or 'normal fertilization'. A significant difference exists between the development potential of oocytes with abnormal pronuclei and those with 2PN. Most recent studies focus on outcomes of blastocysts derived from non-2PN oocytes, suggesting that they have lower blastocyst rates and slightly reduced implantation potential compared to 2PN oocytes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2023)
Review
Obstetrics & Gynecology
Tammy Lee, Jay Natalwala, Vincent Chapple, Yanhe Liu
Summary: With the advancement in computing power and accumulation of embryo image data, artificial intelligence (AI) has been applied in embryo selection in IVF. Machine learning (ML) has the potential to reduce subjectivity and save time, but the lack of interpretability in modern deep learning (DL) techniques has raised concerns. The effectiveness of black-box models lacks confirmation from randomized controlled trials, and recent evidence suggests underperformance compared to interpretable ML models. Interpretable AI is gaining support due to its ethical advantages and technical feasibility. A novel classification system for embryo selection models is proposed, focusing on subjectivity, interpretability, and explainability.
HUMAN REPRODUCTION
(2023)
Meeting Abstract
Obstetrics & Gynecology
B. W. Mol, M. Afnan, J. M. Kemper, F. Xu, G. Liu, L. Xue, X. Bai, H. Liao, S. Xue, S. Zhao, L. Xia, J. Scott, D. Morbeck, Y. Liu
HUMAN REPRODUCTION
(2022)
Article
Obstetrics & Gynecology
Yanh Liu, Kee Ong, Irving Korman, Ross Turner, David Shaker, Deirdre Zander-Fox, Luk Rombauts
Summary: This study found that the timing of assessment on day 5 is a confounding factor in predicting live birth using snapshot blastocyst morphology. A numerical algorithm incorporating day 5 assessment HPI, blastocyst morphology, and maternal age can be developed for live birth prediction.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Obstetrics & Gynecology
Michael Anis Mihdi Afnan, Yanhe Liu, Vincent Conitzer, Cynthia Rudin, Abhishek Mishra, Julian Savulescu, Masoud Afnan
Summary: The potential of using artificial intelligence in the field of in vitro fertilization is significant, but challenges remain in terms of ethical implementation, algorithm interpretability, and clinical accuracy. Current studies show that algorithms can differentiate well between high-quality and poor-quality embryos, but struggle with embryos of similar quality, leading to various epistemic and ethical concerns.
HUMAN REPRODUCTION OPEN
(2021)
Article
Reproductive Biology
Patrycja Kurowska, Ewa Mlyczynska, Julia Wajda, Konrad Krol, Karolina Pich, Patrycja Guzman, Aleksandra Greggio, Oliwia Szkraba, Malgorzata Opydo, Joelle Dupont, Agnieszka Rak
Summary: This study investigated the expression of PNX-14 and GPR173 in ovarian tissue and the effects of PNX-14 on granulosa cell function. The results showed that PNX-14 can influence ovarian follicle growth by promoting granulosa cell proliferation, hormone secretion, and cell cycle progression.
REPRODUCTIVE BIOLOGY
(2024)
Article
Reproductive Biology
Sonia Srivastava, Swarnima Mishra, Gyan Babu, Banalata Mohanty
Summary: This study aimed to investigate the efficacy of PD149163 in preventing/ameliorating LPS-induced inflammation in the female reproductive system of mice. The results showed that PD149163 reduced/prevented the inflammation in the ovary and uterine horn, restored the balance of inflammatory cytokines and oxidative stress, and recovered the levels of reproductive hormones and corticosterone.
REPRODUCTIVE BIOLOGY
(2024)
Article
Reproductive Biology
Chen Zhang, Hongyan Cheng, Xue Ye, Heng Cui, Yi Li, Honglan Zhu, Xiaohong Chang
Summary: Extracellular matrix protein 1 (ECM1) is significantly upregulated in endometriosis tissues. Blocking ECM1 attenuates cell migration and invasion. ECM1 regulates cell migration, invasion, and cytoskeleton reorganization via the RhoC/ROCK1 signaling pathway.
REPRODUCTIVE BIOLOGY
(2024)
