Mass spectrometry and 3-nitrotyrosine: Strategies, controversies, and our current perspective

Determination of nitrotyrosine in Arabidopsis thaliana cell cultures with a mixed-mode solid-phase extraction cleanup followed by liquid chromatography time-of-flight mass spectrometry

(2012) Paula Berton et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Enhanced Sample Multiplexing for Nitrotyrosine-Modified Proteins Using Combined Precursor Isotopic Labeling and Isobaric Tagging

(2012) Renã A. S. Robinson et al.   ANALYTICAL CHEMISTRY

Reactive Nitrogen Oxide Species-Induced Post-Translational Modifications in Human Hemoglobin and the Association with Cigarette Smoking

(2012) Hauh-Jyun Candy Chen et al.   ANALYTICAL CHEMISTRY

Proteomic Approaches to Analyze Protein Tyrosine Nitration

(2012) Maria B. Feeney et al.   ANTIOXIDANTS & REDOX SIGNALING

Developments in the synthesis of a water compatible molecularly imprinted polymer as artificial receptor for detection of 3-nitro-l-tyrosine in neurological diseases

(2012) Lucia Mergola et al.   BIOSENSORS & BIOELECTRONICS

Mass spectrometrical analysis of bilin-binding protein from the wing of Hebomoia glaucippe (Linnaeus, 1758) (Lepidoptera: Pieridae)

(2012) Narkhyun Bae et al.   ELECTROPHORESIS

A simple and robust LC-MS/MS method for quantification of free 3-nitrotyrosine in human plasma from patients receiving on-pump CABG surgery

(2012) Yu Hui et al.   ELECTROPHORESIS

Myeloperoxidase Targets Apolipoprotein A-I, the Major High Density Lipoprotein Protein, for Site-Specific Oxidation in Human Atherosclerotic Lesions

(2012) Baohai Shao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Good mass spectrometry and its place in good science

(2012) Mark W. Duncan   JOURNAL OF MASS SPECTROMETRY

Proteins from Avastin® (bevacizumab) Show Tyrosine Nitrations for which the Consequences Are Completely Unclear

(2012) Jia Wan et al.   PLoS One

Phosphorylation site localization in peptides by MALDI MS/MS and the Mascot Delta Score

(2011) Simone Lemeer et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

A methodology for simultaneous fluorogenic derivatization and boronate affinity enrichment of 3-nitrotyrosine-containing peptides

(2011) Elena S. Dremina et al.   ANALYTICAL BIOCHEMISTRY

Synthesis of Molecularly Imprinted Polymers for Amino Acid Derivates by Using Different Functional Monomers

(2011) Sonia Scorrano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Epitope motif of an anti-nitrotyrosine antibody specific for tyrosine-nitrated peptides revealed by a combination of affinity approaches and mass spectrometry

(2011) Mihaela Drǎguşanu et al.   JOURNAL OF PEPTIDE SCIENCE

Confident identification of 3-nitrotyrosine modifications in mass spectral data across multiple mass spectrometry platforms

(2011) Bensheng Li et al.   Journal of Proteomics

Investigation of local primary structure effects on peroxynitrite-mediated tyrosine nitration using targeted mass spectrometry

(2011) Kent W. Seeley et al.   Journal of Proteomics

Identification of Nitrotyrosine Containing Peptides using Combined Fractional Diagonal Chromatography (COFRADIC) and Off-Line Nano-LC-MALDI

(2011) Trine R. Larsen et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Characterization of Tyrosine Nitration and Cysteine Nitrosylation Modifications by Metastable Atom-Activation Dissociation Mass Spectrometry

(2011) Shannon L. Cook et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Selective Chemoprecipitation and Subsequent Release of Tagged Species for the Analysis of Nitropeptides by Liquid Chromatography–Tandem Mass Spectrometry

(2011) Katalin Prokai-Tatrai et al.   MOLECULAR & CELLULAR PROTEOMICS

The role of nitric oxide in prostaglandin biology; update

(2011) Sangwon F. Kim   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

A stringent approach to improve the quality of nitrotyrosine peptide identifications

(2011) Bart Ghesquière et al.   PROTEOMICS

Analytical methods for 3-nitrotyrosine quantification in biological samples: the unique role of tandem mass spectrometry

(2010) Dimitrios Tsikas   AMINO ACIDS

Protein oxidation: role in signalling and detection by mass spectrometry

(2010) Corinne M. Spickett et al.   AMINO ACIDS

Plasma nitroproteome of kidney disease patients

(2010) Marta Piroddi et al.   AMINO ACIDS

Analysis of nitrated proteins and tryptic peptides by HPLC-chip-MS/MS: site-specific quantification, nitration degree, and reactivity of tyrosine residues

(2010) Yingyi Zhang et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Identification of tyrosine-nitrated proteins in HT22 hippocampal cells during glutamate-induced oxidative stress

(2010) S.-W. Yoon et al.   CELL PROLIFERATION

Efficient Identification and Quantification of Peptides Containing Nitrotyrosine by Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry after Derivatization

(2010) Hiroki Tsumoto et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Measurement of nitrotyrosine in plasma by immunoassays is fraught with danger: commercial availability is no guarantee of analytical reliability

(2010) Dimitrios Tsikas   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Proteomic approaches to oxidative protein modifications implicated in the mechanism of aging

(2010) Tosifusa Toda et al.   Geriatrics & Gerontology International

Cyclooxygenase reaction mechanism of PGHS — Evidence for a reversible transition between a pentadienyl radical and a new tyrosyl radical by nitric oxide trapping

(2010) Jian-Ming Lü et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Physical Evidence for Substrate Binding in Preventing Cyclooxygenase Inactivation under Nitrative Stress

(2010) Ruba S. Deeb et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

On-line bioaffinity-electrospray mass spectrometry for simultaneous detection, identification, and quantification of protein-ligand interactions

(2010) Mihaela Dragusanu et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

Probing the mechanisms of electron capture dissociation mass spectrometry with nitrated peptides

(2010) Andrew W. Jones et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Evidence by gas chromatography–mass spectrometry of ex vivo nitrite and nitrate formation from air nitrogen oxides in human plasma, serum, and urine samples

(2009) Dimitrios Tsikas et al.   ANALYTICAL BIOCHEMISTRY

Chemical Approach for Specific Enrichment and Mass Analysis of Nitrated Peptides

(2009) Jung Rok Lee et al.   ANALYTICAL CHEMISTRY

Preferentially Increased Nitration of α-Synuclein at Tyrosine-39 in a Cellular Oxidative Model of Parkinson’s Disease

(2009) Steven R. Danielson et al.   ANALYTICAL CHEMISTRY

Oxidative stress and human diseases: Origin, link, measurement, mechanisms, and biomarkers

(2009) Daniela Giustarini et al.   CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES

Misidentification of nitrated peptides: Comments on Hong, S.J., Gokulrangan, G., Schöneich, C., 2007. Proteomic analysis of age-dependent nitration of rat cardiac proteins by solution isoelectric focusing coupled to nanoHPLC tandem mass spectrometry. Exp. Gerontol. 42, 639–651

(2009) Laszlo Prokai   EXPERIMENTAL GERONTOLOGY

Modification of surfactant protein D by reactive oxygen-nitrogen intermediates is accompanied by loss of aggregating activity, in vitro and in vivo

(2009) Sadis Matalon et al.   FASEB JOURNAL

Nitrated plasma albumin as a marker of nitrative stress and neonatal encephalopathy in perinatal asphyxia

(2009) Jean-Louis Wayenberg et al.   FREE RADICAL BIOLOGY AND MEDICINE

Lipid peroxidation: Physiological levels and dual biological effects

(2009) Etsuo Niki   FREE RADICAL BIOLOGY AND MEDICINE

GC–MS analysis of S-nitrosothiols after conversion to S-nitroso-N-acetyl cysteine ethyl ester and in-injector nitrosation of ethyl acetate

(2009) Dimitrios Tsikas et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

De novo synthesis of trideuteromethyl esters of amino acids for use in GC–MS and GC-tandem MS exemplified for ADMA in human plasma and urine: Standardization, validation, comparison and proof of evidence for their aptitude as internal standards

(2009) Dimitrios Tsikas   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Specific GC–MS/MS stable-isotope dilution methodology for free 9- and 10-nitro-oleic acid in human plasma challenges previous LC–MS/MS reports

(2009) Dimitrios Tsikas et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Review of statistical methodologies used to compare (bio)assays

(2009) Walthère Dewé   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

A proposal for comparing methods of quantitative analysis of endogenous compounds in biological systems by using the relative lower limit of quantification (rLLOQ)

(2009) Dimitrios Tsikas   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Method validation across the disciplines—Critical investigation of major validation criteria and associated experimental protocols

(2009) Dietmar Stöckl et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Validation of bioanalytical LC–MS/MS assays: Evaluation of matrix effects

(2009) Ann Van Eeckhaut et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Quantitative analysis of biomarkers, drugs and toxins in biological samples by immunoaffinity chromatography coupled to mass spectrometry or tandem mass spectrometry: A focused review of recent applications

(2009) Dimitrios Tsikas   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Quantification of Modified Tyrosines in Healthy and Diabetic Human Urine using Liquid Chromatography/Tandem Mass Spectrometry

(2009) Yoji Kato et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Site-Specific Carboxypeptidase B1 Tyrosine Nitration and Pathophysiological Implications following Its Physical Association with Nitric Oxide Synthase-3 in Experimental Sepsis

(2009) S. Chatterjee et al.   JOURNAL OF IMMUNOLOGY

Protein Tyrosine Nitration: Selectivity, Physicochemical and Biological Consequences, Denitration, and Proteomics Methods for the Identification of Tyrosine-Nitrated Proteins

(2009) Nicolas Abello et al.   JOURNAL OF PROTEOME RESEARCH

Electron capture dissociation mass spectrometry of tyrosine nitrated peptides

(2009) Andrew W. Jones et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

In Vitroandin VivoProtein-bound Tyrosine Nitration Characterized by Diagonal Chromatography

(2009) Bart Ghesquière et al.   MOLECULAR & CELLULAR PROTEOMICS

Nitrite correlates with 3-nitrotyrosine but not with the F2-isoprostane 15(S)-8-iso-PGF2α in urine of rheumatic patients

(2009) V. Vi Pham et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Characterization of Detergent-Insoluble Proteins in ALS Indicates a Causal Link between Nitrative Stress and Aggregation in Pathogenesis

(2009) Manuela Basso et al.   PLoS One

Mechanism of glyceraldehyde-3-phosphate dehydrogenase inactivation by tyrosine nitration

(2009) Vikram Palamalai et al.   PROTEIN SCIENCE

Quantifying proteins by mass spectrometry: The selectivity of SRM is only part of the problem

(2009) Mark W. Duncan et al.   PROTEOMICS

Quantitative identification of protein nitration sites

(2009) Giovanni Chiappetta et al.   PROTEOMICS

Chemical labeling and enrichment of nitrotyrosine-containing peptides

(2009) Nicolas Abello et al.   TALANTA

Monitoring oxidative and nitrative modification of cellular proteins; a paradigm for identifying key disease related markers of oxidative stress☆

(2008) James Murray et al.   ADVANCED DRUG DELIVERY REVIEWS

Immunoaffinity liquid chromatography–tandem mass spectrometry detection of nitrotyrosine in biological fluids: Development of a clinically translatable biomarker

(2008) Melissa R. Radabaugh et al.   ANALYTICAL BIOCHEMISTRY

A critical review and discussion of analytical methods in the l-arginine/nitric oxide area of basic and clinical research

(2008) Dimitrios Tsikas   ANALYTICAL BIOCHEMISTRY

Nitroavidin as a Ligand for the Surface Capture and Release of Biotinylated Proteins

(2008) Jowell G. Bolivar et al.   ANALYTICAL CHEMISTRY

Inactivation of rabbit muscle glycogen phosphorylase b by peroxynitrite revisited: Does the nitration of Tyr 613 in the allosteric inhibition site control enzymatic function?

(2008) Victor S. Sharov et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: Mitochondria as the major target

(2008) Bin Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The mechanism of oleic acid nitration by •NO2

(2008) Kavita Jain et al.   FREE RADICAL BIOLOGY AND MEDICINE

MALDI-induced fragmentation of leucine enkephalin, nitro-Tyr-leucine enkaphalin, and d5-Phe-nitro-Tyr-leucine enkephalin

(2008) Xianquan Zhan et al.   INTERNATIONAL JOURNAL OF MASS SPECTROMETRY

Post-translational Tyrosine Nitration of Eosinophil Granule Toxins Mediated by Eosinophil Peroxidase

(2008) Martina Ulrich et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Tyrosine Nitration of the Flavin Subunit Is Associated with Oxidative Modification of Mitochondrial Complex II in the Post-ischemic Myocardium

(2008) Chwen-Lih Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Key aspects of analytical method validation and linearity evaluation

(2008) Pedro Araujo   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Proteomic identification of nitrated brain proteins in traumatic brain-injured rats treated postinjury with gamma-glutamylcysteine ethyl ester: Insights into the role of elevation of glutathione as a potential therapeutic strategy for traumatic brain injury

(2008) Tanea T. Reed et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Factors That Contribute to the Misidentification of Tyrosine Nitration by Shotgun Proteomics

(2008) Stanley M. Stevens et al.   MOLECULAR & CELLULAR PROTEOMICS

Plasma 3-nitrotyrosine is a biomarker in animal models of arthritis: Pharmacological dissection of iNOS’ role in disease

(2008) Olga V. Nemirovskiy et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Simultaneous detection and quantification of 3-nitrotyrosine and 3-bromotyrosine in human urine by stable isotope dilution liquid chromatography tandem mass spectrometry

(2008) Hauh-Jyun Candy Chen et al.   TOXICOLOGY LETTERS

H2O2/Nitrite-Induced Post-translational Modifications of Human Hemoglobin Determined by Mass Spectrometry: Redox Regulation of Tyrosine Nitration and 3-Nitrotyrosine Reduction by Antioxidants

(2007) Hauh-Jyun Candy Chen et al.   CHEMBIOCHEM