Journal
MARINE DRUGS
Volume 16, Issue 9, Pages -Publisher
MDPI
DOI: 10.3390/md16090329
Keywords
deep-sea derived fungus; Phomopsis lithocarpus; benzophenone derivatives; eremophilane derivative
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Funding
- Science and Technology Program of Guangzhou, China [201607020018]
- Natural Science Foundation of Guangdong Province [2016A030312014]
- National Natural Science Foundation of China [31272087]
- Guangdong Provincial Innovative Development of Marine Economy Regional Demonstration Projects [GD2012-D01-002]
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Five new benzophenone derivatives named tenellones D-H (1-5), sharing a rare naturally occurring aldehyde functionality in this family, and a new eremophilane derivative named lithocarin A (7), together with two known compounds (6 and 8), were isolated from the deep marine sediment-derived fungus Phomopsis lithocarpus FS508. All of the structures for these new compounds were fully characterized and established on the basis of extensive spectroscopic interpretation and X-ray crystallographic analysis. Compound 5 exhibited cytotoxic activity against HepG-2 and A549 cell lines with IC50 values of 16.0 and 17.6 M, respectively.
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