Journal
MARINE DRUGS
Volume 16, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/md16080282
Keywords
deep-sea-derived bacterium; Ochrobactrum sp.; ansamycins; trienomycins; cytotoxic activity
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Funding
- National Natural Science Foundation of China (NSFC) [81561148012, U1501221, U1606403]
- Thailand Research Fund (TRF) through the International Research Network [IRN-58W0004]
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Two new ansamycins, trienomycins H (1) and I (2), together with the known trienomycinol (3), were isolated from the fermentation broth of the deep-sea-derived bacterium Ochrobactrum sp. OUCMDZ-2164. Their structures, including their absolute configurations, were elucidated based on spectroscopic analyses, ECD spectra, and Marfey's method. Compound 1 exhibited cytotoxic effects on A549 and K562 cell lines with IC50 values of 15 and 23 mu M, respectively.
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