Article
Multidisciplinary Sciences
Angelica Enrique-Navarro, I. Emma Huertas, Manuel Jesus Leon Cobo, Laura Prieto
Summary: This study reveals that the polyps of Cotylorhiza tuberculata could adapt to the worst-case scenario predicted for the Mediterranean Sea in the future. However, under high acidification and warming conditions, their ability to properly strobilate and produce healthy ephyrae will be more vulnerable to environmental factors induced by climate change, ultimately affecting medusae recruitment and the population dynamics of the species.
Article
Ecology
Rebecca M. Wright, Corinne Le Quere, Erik Buitenhuis, Sophie Pitois, Mark J. Gibbons
Summary: This study introduces a global ocean biogeochemical model that includes jellyfish and reveals that jellyfish play a vital role in regulating plankton communities, particularly through trophic cascades.
Review
Biodiversity Conservation
Cornelia Jaspers, Nicholas Bezio, Hans-Harald Hinrichsen
Summary: Global change has led to various changes in marine ecosystems and biodiversity worldwide. In the Baltic Sea, the arrival and establishment of non-indigenous jellyfish species have increased their importance in the region, particularly due to their high population densities and grazing impact.
Article
Biochemistry & Molecular Biology
Rongfeng Li, Huahua Yu, Aoyu Li, Chunlin Yu, Pengcheng Li
Summary: In this study, a key lethal toxin (Letoxcn) was isolated from the jellyfish Cyanea nozakii. Its molecular weight is about 50 kDa and the N-terminal sequence is QADAEKVNLPVGVCV. Peptide mass fingerprinting analysis suggests that Letoxcn may have motifs of phospholipase, metalloprotease, thrombin-like enzyme, potassium channel inhibitor, etc. However, in vitro toxicity analysis only showed metalloprotease activity and no hemolytic, PLA2, or blood coagulation activity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Food Science & Technology
Rongfeng Li, Huahua Yu, Aoyu Li, Chunlin Yu, Pengcheng Li
Summary: Jellyfish stings are a common issue globally, and a specific antivenom is necessary for severe cases.
Article
Chemistry, Applied
Mikhail Torlopov, Oksana Shevchenko, Natalya Drozd, Elena Udoratina
Summary: Small molecules are not effective in antioxidant therapy for cardiovascular diseases, so hemocompatible polymeric antioxidants are considered as a potential alternative. In this study, a new polymeric antioxidant called CSt-DiBP was synthesized by attaching terpenophenol to cationic starch. The resulting compounds showed lower viscosity and rheopexy properties in water solutions. CSt-DiBPs exhibited high antioxidant activity and effectively protected erythrocytes under conditions of acute oxidative stress. In vitro analysis showed that the synthesized polymeric antioxidants had high hemocompatibility and did not affect plasma coagulation in vivo.
REACTIVE & FUNCTIONAL POLYMERS
(2023)
Article
Limnology
Pengpeng Wang, Fang Zhang, Song Sun, Shuguo Lue
Summary: This study reports on the feeding behavior and prey selection patterns of the common jellyfish Cyanea nozakii in offshore China, as well as its intraguild predation on Aurelia coerulea. The results show that C. nozakii preys preferentially on gelatinous organisms, with higher efficiency for smaller prey, and the clearance rate increases with the size of C. nozakii. However, the clearance rate decreases when preying on larger A. coerulea.
JOURNAL OF OCEANOLOGY AND LIMNOLOGY
(2023)
Article
Plant Sciences
Mustapha Tacherfiout, Sarah Kherbachi, Meriem Kheniche, Marco Mattonai, Ilaria Degano, Erika Ribechini, Bachra Khettal
Summary: This study aimed to investigate the phenolic composition, antioxidant, and antihemolytic effects of hydroalcoholic extracts of Chamaemelum nobile (CN) and Mentha pulegium (MP). The results showed that both extracts exhibited good antioxidant activity and significantly reduced oxidative damage in human erythrocytes induced by AAPH.
SOUTH AFRICAN JOURNAL OF BOTANY
(2022)
Article
Biochemistry & Molecular Biology
Siying Li, Xin Luo, Suhan Zhang, Yuwen Su, Min Deng, Yanshan Zhu, Peng Zhang, Ruifang Wu, Ming Zhao
Summary: This study suggests that ferroptosis activation due to iron overload may be a novel mechanism underlying the formation of skin lesions in individuals with psoriasis.
Article
Medicine, Research & Experimental
Pakawit Lerksaipheng, Kittiphong Paiboonsukwong, Pimtip Sanvarinda, Rataya Leuchapudiporn, Ken-Ichi Yamada, Noppawan Phumala Morales
Summary: This study suggests that vascular complications in patients with beta-thalassemia are associated with oxidative modification of lipoproteins. The modification of lipid components may alter lipid peroxidation rate and products. Core lipids and cholesteryl esters levels determine the rate and total production of L center dot. Overall, lipoproteins in beta-thalassemia patients are more susceptible to lipid peroxidation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Magdalena Kulma, Gregor Anderluh
Summary: Pore-forming proteins (PFPs) alter membrane permeability by forming transmembrane pores, destroying target cells and potentially manipulating cellular functions. Recent evidence suggests that PFPs also induce extensive membrane reorganization, including lateral rearrangement and deformation, which can disrupt cell function and lead to death. These modifications are also part of a membrane repair system that protects cells from the lethal effects of pore formation.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Konstantin N. Belosludtsev, Vlada S. Starinets, Eugeny Yu Talanov, Irina B. Mikheeva, Mikhail Dubinin, Natalia Belosludtseva
Summary: Alisporivir has a positive impact on glucose utilization in diabetic mice, preventing diabetes-induced changes in mitochondrial ultrastructure and ATP synthase levels, and restoring mitochondrial function. Additionally, Alisporivir modulates mitochondrial gene expression, inhibits sensitivity to MPT pore opening, and normalizes mitochondrial dynamics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ewa Olchowik-Grabarek, Szymon Sekowski, Frederique Mies, Maciej Bitiucki, Izabela Swiecicka, Nodira Abdulladjanova, Vadim Shlyonsky, Maria Zamaraeva
Summary: Using bilayer lipid membrane technique, this study reveals that two tannins (PGG and dGVG) possess antihemolytic activity by inhibiting the formation and conductivity of alpha-hemolysin channels. Spectroscopic analysis shows that these tannins form complexes with hemolysin, disrupting its interaction with the membrane. Moreover, PGG can block the release of the toxin by bacterial cells. These findings suggest the therapeutic potential of PGG and other tannins in combating S. aureus virulence.
BIOELECTROCHEMISTRY
(2023)
Editorial Material
Oncology
Jose Pedro Friedmann Angeli, Thamara Nishida Xavier da Silva, Bastian Schilling
Summary: In this study, Liao et al. show that CD8(+) T cell-secreted IFN-γ rewires cancer cell lipid metabolism via ACSL4, activating polyunsaturated fatty acids and sensitizing cancer cells to ferroptosis in immunotherapy-relevant settings.
Article
Biochemistry & Molecular Biology
Yajing You, Chenxi Liu, Tiantian Liu, Miaomiao Tian, Nijin Wu, Zhen Yu, Fenglin Zhao, Jianni Qi, Qiang Zhu
Summary: This study reveals the crucial role of FNDC3B in protecting against hepatic steatosis and ferroptosis in response to chronic alcohol consumption. Our findings suggest that FNDC3B could be a potential therapeutic target for ALD.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qinghua Liu, Donghui Pan, Chao Cheng, Anyu Zhang, Chao Ma, Lizhen Wang, Dazhi Zhang, Hongrui Liu, Hongdie Jiang, Tao Wang, Yuping Xu, Runlin Yang, Fei Chen, Min Yang, Changjing Zuo
NUCLEAR MEDICINE AND BIOLOGY
(2015)
Article
Chemistry, Multidisciplinary
Tao Wang, Guorong Jia, Chao Cheng, Qiuhu Wang, Xiao Li, Yanyan Liu, Chaofan He, Luguang Chen, Gaofeng Sun, Changjing Zuo
NEW JOURNAL OF CHEMISTRY
(2018)
Article
Engineering, Biomedical
Gaofeng Sun, Tao Wang, Xiao Li, Danni Li, Ye Peng, Xiaoke Wang, Guorong Jia, Weiwei Su, Chao Cheng, Jian Yang, Changjing Zuo
ADVANCED HEALTHCARE MATERIALS
(2018)
Article
Biochemistry & Molecular Biology
Guixia Pan, Danni Li, Xiao Li, Ye Peng, Tao Wang, Changjing Zuo
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Cardiac & Cardiovascular Systems
Lin Zhang, Qian He, Qianqian Wang, Bo Zhang, Beilei Wang, Feng Xu, Tao Wang, Liang Xiao, Liming Zhang
CARDIOVASCULAR TOXICOLOGY
(2014)
Article
Pharmacology & Pharmacy
Tao Wang, Qian He, Liang Xiao, Qianqian Wang, Bo Zhang, Beilei Wang, Guoyan Liu, Jiemin Zheng, Bentong Yu, Liming Zhang
Article
Pharmacology & Pharmacy
Beilei Wang, Lin Zhang, Jiemin Zheng, Qianqian Wang, Tao Wang, Jia Lu, Xiaojuan Wen, Bo Zhang, Guoyan Liu, Wei Zhang, Liang Xiao, Liming Zhang
Article
Pharmacology & Pharmacy
Beilei Wang, Bo Zhang, Hua Huo, Tao Wang, Qianqian Wang, Yuanlin Wu, Liang Xiao, Yuqi Ren, Liming Zhang
Article
Biochemical Research Methods
Chao Wang, Beilei Wang, Bo Wang, Qanqian Wang, Guoyan Liu, Tao Wang, Qian He, Liming Zhang
JOURNAL OF PROTEOME RESEARCH
(2019)
Article
Oncology
Tao Wang, Jian Yang, Juanli Mao, Lizhi Zhu, Xiu Luo, Chao Cheng, Lu Zhang
Summary: The interaction between pancreatic cancer cells and pancreatic stellate cells plays a crucial role in the aggressive progression of pancreatic cancer. This study found that inhibiting the activity of ITGA5, a protein overexpressed in pancreatic cancer stroma and activated PSCs, impairs the proliferation and migration of PSCs and enhances autophagy. Additionally, ITGA5 inhibition prevents pancreatic cancer cells from acquiring cancer stem cell-like characteristics. These findings suggest that targeting ITGA5 could be a promising therapeutic strategy for pancreatic cancer by disrupting the tumor-stromal crosstalk.