Recently Confirmed Apoptosis-Inducing Lead Compounds Isolated from Marine Sponge of Potential Relevance in Cancer Treatment

Recent advances in apoptosis, mitochondria and drug resistance in cancer cells

(2011) Inthrani R. Indran et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

First-In-Man Study of CPX-351: A Liposomal Carrier Containing Cytarabine and Daunorubicin in a Fixed 5:1 Molar Ratio for the Treatment of Relapsed and Refractory Acute Myeloid Leukemia

(2011) Eric J. Feldman et al.   JOURNAL OF CLINICAL ONCOLOGY

Antiproliferative and Antiangiogenic Activities of Smenospongine, a Marine Sponge Sesquiterpene Aminoquinone

(2011) Dexin Kong et al.   Marine Drugs

Report of a Phase II Study of Clofarabine and Cytarabine in De Novo and Relapsed and Refractory AML Patients and in Selected Elderly Patients at High Risk for Anthracycline Toxicity

(2011) E. Agura et al.   ONCOLOGIST

Asymmetric synthesis of Pachastrissamine (Jaspine B) and its diastereomers viaη3-allylpalladium intermediates

(2011) Mikko Passiniemi et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The marine alkaloid naamidine A promotes caspase-dependent apoptosis in tumor cells

(2010) Daniel V. LaBarbera et al.   ANTI-CANCER DRUGS

Globostelletins A–I, cytotoxic isomalabaricane derivatives from the marine sponge Rhabdastrella globostellata

(2010) Jin Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Phase III Trials of Eribulin Mesylate (E7389) in Extensively Pretreated Patients With Locally Recurrent or Metastatic Breast Cancer

(2010) Chris Twelves et al.   Clinical Breast Cancer

Activation of p38 MAPK by damnacanthal mediates apoptosis in SKHep 1 cells through the DR5/TRAIL and TNFR1/TNF-α and p53 pathways

(2010) Feng-Lang Lin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The marine compound spongistatin 1 targets pancreatic tumor progression and metastasis

(2010) Andrea S. Rothmeier et al.   INTERNATIONAL JOURNAL OF CANCER

Geoditin A Induces Oxidative Stress and Apoptosis on Human Colon HT29 Cells

(2010) Florence W. K. Cheung et al.   Marine Drugs

Marine Drugs from Sponge-Microbe Association—A Review

(2010) Tresa Remya A. Thomas et al.   Marine Drugs

Marine natural products

(2010) John W. Blunt et al.   NATURAL PRODUCT REPORTS

Marine natural products

(2010) John W. Blunt et al.   NATURAL PRODUCT REPORTS

Database resources of the National Center for Biotechnology Information

(2010) E. W. Sayers et al.   NUCLEIC ACIDS RESEARCH

Monanchocidin: A New Apoptosis-Inducing Polycyclic Guanidine Alkaloid from the Marine SpongeMonanchora pulchra

(2010) Alla G. Guzii et al.   ORGANIC LETTERS

Rhabdastrellic Acid-A Induced Autophagy-Associated Cell Death through Blocking Akt Pathway in Human Cancer Cells

(2010) Dan-Dan Li et al.   PLoS One

Irciniastatin A induces JNK activation that is involved in caspase-8-dependent apoptosis via the mitochondrial pathway

(2010) Takumi Chinen et al.   TOXICOLOGY LETTERS

The natural marine anhydrophytosphingosine, Jaspine B, induces apoptosis in melanoma cells by interfering with ceramide metabolism

(2009) Yahya Salma et al.   BIOCHEMICAL PHARMACOLOGY

Heteronemin, a spongean sesterterpene, inhibits TNFα-induced NF-κB activation through proteasome inhibition and induces apoptotic cell death

(2009) Marc Schumacher et al.   BIOCHEMICAL PHARMACOLOGY

Differential Induction of Apoptosis of Leukemic Cells by Rhizochalin, Two Headed Sphingolipids from Sponge and Its Derivatives

(2009) Jun-O Jin et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

C29 sterols with a cyclopropane ring at C-25 and 26 from the Vietnamese marine sponge Ianthella sp. and their anticancer properties

(2009) Nguyen Huu Tung et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The inositol 1,4,5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1

(2009) J M Vicencio et al.   CELL DEATH AND DIFFERENTIATION

Phase II Study of Eribulin Mesylate, a Halichondrin B Analog, in Patients With Metastatic Breast Cancer Previously Treated With an Anthracycline and a Taxane

(2009) Linda T. Vahdat et al.   JOURNAL OF CLINICAL ONCOLOGY

Polyacetylene diols with antiproliferative and driving Th1 polarization effects from the marine sponge Callyspongia sp.

(2009) Akemi Umeyama et al.   Journal of Natural Medicines

Marine Two-Headed Sphingolipid-Like Compound Rhizochalin Inhibits EGF-Induced Transformation of JB6 P+ Cl41 Cells

(2009) Sergey N. Fedorov et al.   LIPIDS

BH3-only proteins Mcl-1 and Bim as well as endonuclease G are targeted in spongistatin 1-induced apoptosis in breast cancer cells

(2009) U. M. Schneiders et al.   MOLECULAR CANCER THERAPEUTICS

Marine natural products

(2009) John W. Blunt et al.   NATURAL PRODUCT REPORTS

Asymmetric Total Syntheses of (−)-Renieramycin M and G and (−)-Jorumycin Using Aziridine as a Lynchpin

(2009) Yan-Chao Wu et al.   ORGANIC LETTERS

Potential chemical defenses of Antarctic sponges against sympatric microorganisms

(2009) Kevin J. Peters et al.   POLAR BIOLOGY

Synthesis of BC-ring model of globostellatic acid X methyl ester, an anti-angiogenic substance from marine sponge

(2008) Naoyuki Kotoku et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Induction of apoptosis accompanying with G1 phase arrest and microtubule disassembly in human hepatoma cells by jaspolide B, a new isomalabaricane-type triterpene

(2008) Shao-Yin Wei et al.   CANCER LETTERS

Intravesical Chemotherapy of High-Grade Bladder Cancer with HTI-286, A Synthetic Analogue of the Marine Sponge Product Hemiasterlin

(2008) B. A. Hadaschik et al.   CLINICAL CANCER RESEARCH

Induction of apoptosis in endometrial cancer cells by psammaplysene A involves FOXO1

(2008) Emily Berry et al.   GYNECOLOGIC ONCOLOGY

Clionapyrrolidine A—A Metabolite from the Encrusting and Excavating Sponge Cliona tenuis that Kills Coral Tissue upon Contact

(2008) Andia Chaves-Fonnegra et al.   JOURNAL OF CHEMICAL ECOLOGY

Induction of Apoptosis in Human Cancer Cells by Candidaspongiolide, a Novel Sponge Polyketide

(2008) Daniela Trisciuoglio et al.   JNCI-Journal of the National Cancer Institute

Spongistatin 1: a new chemosensitizing marine compound that degrades XIAP

(2008) L Schyschka et al.   LEUKEMIA

Phase I study of cladribine, cytarabine (Ara-C), granulocyte colony stimulating factor (G-CSF) (CLAG Regimen) and simultaneous escalating doses of imatinib mesylate (Gleevec) in relapsed/refractory AML

(2008) Alison R. Walker et al.   LEUKEMIA RESEARCH

Marine natural products

(2008) John W. Blunt et al.   NATURAL PRODUCT REPORTS

Autophagy-Modulating Aminosteroids Isolated from the SpongeCliona celata

(2008) Robert A. Keyzers et al.   ORGANIC LETTERS