Journal
MALARIA JOURNAL
Volume 13, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1475-2875-13-25
Keywords
Malaria; Virulence; Mosquito transmission; Immunity
Categories
Funding
- Wellcome Trust Funding Source: Medline
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A recent study found that mosquito-transmitted (MT) lines of rodent malaria parasites elicit a more effective immune response than non-transmitted lines maintained by serial blood passage (non-MT), thereby causing lower parasite densities in the blood and less pathology to the host. The authors attribute these changes to higher diversity in expression of antigen-encoding genes in MT cf. non-MT lines. Alternative explanations that are equally parsimonious with these new data, and results from previous studies, suggest that this conclusion may be premature.
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