Article
Infectious Diseases
Charles O. Obonyo, Elizabeth A. Juma, Vincent O. Were, Bernhards R. Ogutu
Summary: This study found that a 3-day low dose course of quinine plus clindamycin is not effective in treating uncomplicated falciparum malaria in children under 5 years of age in Kenya, where artemether-lumefantrine remains effective.
Review
Medicine, General & Internal
Makoto Saito, Rose McGready, Halidou Tinto, Toussaint Rouamba, Dominic Mosha, Stephen Rulisa, Simon Kariuki, Meghna Desai, Christine Manyando, Eric M. Njunju, Esperanca Sevene, Anifa Vala, Orvalho Augusto, Christine Clerk, Edwin Were, Sigilbert Mrema, William Kisinza, Josaphat Byamugisha, Mike Kagawa, Jan Singlovic, Mackensie Yore, Anna Maria van Eijk, Ushma Mehta, Andy Stergachis, Jenny Hill, Kasia Stepniewska, Melba Gomes, PhilippeJ Guerin, Francois Nosten, Feiko O. ter Kuile, Stephanie Dellicour
Summary: This study compared adverse pregnancy outcomes in the first trimester of pregnancy after artemisinin-based treatment (ABT) versus non-ABTs. The results showed no evidence of embryotoxicity or teratogenicity associated with ABT during the first trimester. Artemether-lumefantrine was found to be the preferred treatment for uncomplicated P falciparum malaria in the first trimester, with fewer adverse pregnancy outcomes compared to quinine.
Article
Multidisciplinary Sciences
Nicholas Nyaaba, Nana Efua Andoh, Gordon Amoh, Dominic Selorm Yao Amuzu, Mary Ansong, Jose M. Ordonez-Mena, Jennifer Hirst
Summary: A network meta-analysis was conducted to evaluate the efficacy and safety of artemisinin derivatives and quinine for severe Plasmodium falciparum malaria. The results showed that artesunate reduced mortality in children and adults, including cerebral malaria. However, there was no consistent superiority among the artemisinin drugs in the assessed outcomes.
Review
Multidisciplinary Sciences
Yonas Yimam, Mehdi Mohebali, Mohammad Javad Abbaszadeh Afshar
Summary: This study compared the diagnostic performance of a new ultrasensitive rapid diagnostic test (us-RDT) and a conventional rapid diagnostic test (co-RDT) for detecting malaria. The results showed that us-RDT had higher sensitivity, especially in asymptomatic individuals and low transmission areas.
Review
Biology
Aongart Mahittikorn, Frederick Ramirez Masangkay, Kwuntida Uthaisar Kotepui, Wanida Mala, Giovanni De Jesus Milanez, Polrat Wilairatana, Manas Kotepui
Summary: This systematic review synthesized evidence on the risks of severe and profound thrombocytopenia in patients with severe non-Plasmodium falciparum malaria. The high prevalence of severe and profound thrombocytopenia, along with the associated mortality rate, suggests that severe thrombocytopenia should serve as a warning sign, especially in patients with P. vivax and P. knowlesi infections, for timely and appropriate treatment according to WHO guidelines.
Review
Biology
Polrat Wilairatana, Wanida Mala, Manas Kotepui, Kwuntida Uthaisar Kotepui
Summary: The study demonstrated significant differences in blood lactate levels between patients with severe malaria and those with uncomplicated malaria, as well as between patients who died from severe malaria and those who survived. Further research is required to explore the prognostic value of blood lactate levels in identifying high-risk patients with severe malaria or at risk of death.
Review
Multidisciplinary Sciences
Muhammad Imran Khan, Humera Qureshi, Suk Joo Bae, Aamer Ali Khattak, Muhammad Shahid Anwar, Sadique Ahmad, Fazal Hassan, Shabir Ahmad
Summary: This study conducted a systematic review and meta-analysis on malaria prevalence in Pakistan from 2006 to 2021. Out of the 315 studies collected, only 45 full-text articles were included in the final meta-analysis. The pooled malaria prevalence in Pakistan was 23.3%, with Plasmodium vivax, Plasmodium falciparum, and mixed infection rates of 79.13%, 16.29%, and 3.98%, respectively.
Review
Medicine, General & Internal
Andrew Blanshard, Paul Hine
Summary: This study reviewed 17 randomized controlled trials with 4763 participants from Africa, South-America, and South-East Asia, assessing the efficacy and safety of atovaquone-proguanil in treating uncomplicated Plasmodium falciparum malaria. The study found that atovaquone-proguanil was effective against complicated malaria, and the addition of artesunate may reduce treatment failure rates.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Review
Multidisciplinary Sciences
Manas Kotepui, Kwuntida Uthaisar Kotepui, Frederick Ramirez Masangkay, Aongart Mahittikorn, Polrat Wilairatana
Summary: This systematic review aimed to evaluate the prevalence and proportion of asymptomatic Plasmodium infection in Asia. The results showed a low prevalence of asymptomatic Plasmodium infection in different parts of Asia, but a high proportion of asymptomatic infection among all parasitised individuals. These findings are important for the elimination and control programs of asymptomatic Plasmodium infection in Asia.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Katherine O'Flaherty, Jo-Anne Chan, Julia C. Cutts, Sophie G. Zaloumis, Elizabeth A. Ashley, Aung Pyae Phyo, Damien R. Drew, Arjen M. Dondorp, Nicholas P. Day, Mehul Dhorda, Rick M. Fairhurst, Pharath Lim, Chanaki Amaratunga, Sasithon Pukrittayakamee, Tran Tinh Hien, Ye Htut, Mayfong Mayxay, M. Abul Faiz, Olugbenga A. Mokuolu, Marie A. Onyamboko, Caterina Fanello, Eizo Takashima, Takafumi Tsuboi, Michael Theisen, Francois Nosten, James G. Beeson, Julie A. Simpson, Nicholas J. White, Freya J. Fowkes
Summary: The study found that Pfs230 and Pfs48/45 antibodies are associated with patent gametocytemia and increasing gametocyte density across multiple malaria endemic settings, including regions with emerging artemisinin-resistant P. falciparum.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Infectious Diseases
Celestin Danwang, Fati Kirakoya-Samadoulougou, Sekou Samadoulougou
Summary: This study conducted a meta-analysis comparing the sensitivity and specificity of the newly developed ultrasensitive Plasmodium falciparum malaria RDT with the conventional RDT in the same field conditions. The ultrasensitive RDT showed higher sensitivity but lower specificity compared to the conventional RDT.
Article
Multidisciplinary Sciences
Polrat Wilairatana, Wanida Mala, Giovanni De Jesus Milanez, Frederick Ramirez Masangkay, Kwuntida Uthaisar Kotepui, Manas Kotepui
Summary: This systematic review and meta-analysis compared IL-6 levels between different groups of malaria patients and healthy controls. The results showed significantly higher levels of IL-6 in patients with severe malaria compared to those with non-severe malaria, as well as in patients with uncomplicated malaria compared to the control group. However, no significant differences in IL-6 levels were found between patients with uncomplicated malaria and asymptomatic malaria, or between patients with asymptomatic malaria and healthy controls. Higher IL-6 levels were observed in patients who died compared to those who survived. These findings are important for monitoring and studying the severity of malaria.
SCIENTIFIC REPORTS
(2022)
Editorial Material
Infectious Diseases
Sanjeev Krishna, Peter G. Kremsner
Summary: This commentary raises questions about the methodology of Obonyo et al.'s malaria treatment study, particularly regarding the chosen time points for measuring treatment outcomes.
Review
Infectious Diseases
Erni J. J. Nelwan, Sharifah Shakinah, Adeline Pasaribu
Summary: This study analyzed the association between glucose-6-phosphate-dehydrogenase deficiency (G6PDd) and anemia in malaria patients receiving anti-malarial drugs. The study found that single or daily standard doses of primaquine (0.25 mg/kg/day) and weekly primaquine (0.75 mg/kg/week) did not increase the risk of anemia in G6PDd patients.
Article
Medicine, General & Internal
Aita W. Signorell, Phyllis Awor, Jean Okitawutshu, Antoinette Tshefu, Elizabeth Omoluabi, Manuel Hetzel, Proscovia K. Athieno, Joseph Kimera, Gloria Tumukunde, Irene Angiro, Jean-Claude Kalenga, Babatunde T. Akano, Kazeem C. Ayodeji, Charles J. Okon, Ocheche Yusuf, Giulia Delvento, Tristan Lee, Nina Brunner, Mark G. Lambiris, James Okuma, Nadja Cereghetti, Valentina Buj, Theodoor Visser, Harriet Napier, Christian Lengeler, Christian Burri
Summary: This study aimed to assess compliance with the recommended treatment for severe malaria in children under 5 years old. The findings showed that directly observed treatment was often incomplete, posing a high risk for partial parasite clearance and disease recurrence. Strict compliance with the WHO guidelines for severe malaria treatment is critical to effectively manage the disease and further reduce child mortality.
Article
Public, Environmental & Occupational Health
Janet Agaya, Chimeremma D. Nnadi, Joseph Odhiambo, Charles Obonyo, Vincent Obiero, Virginia Lipke, Elisha Okeyo, Kevin Cain, John E. Oeltmann
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2015)
Article
Microbiology
Ali Mohamed Ali, Melissa A. Penny, Thomas A. Smith, Lesley Workman, Philip Sasi, George O. Adjei, Francesca Aweeka, Jean-Rene Kiechel, Vincent Jullien, Marcus J. Rijken, Rose McGready, Julia Mwesigwa, Kim Kristensen, Kasia Stepniewska, Joel Tarning, Karen I. Barnes, Paolo Denti
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2018)
Article
Medicine, General & Internal
W. Robert Taylor, Htee Khu Naw, Kathryn Maitland, Thomas N. Williams, Melissa Kapulu, Umberto D'Alessandro, James A. Berkley, Philip Bejon, Joseph Okebe, Jane Achan, Alfred Ngwa Amambua, Muna Affara, Davis Nwakanma, Jean-Pierre van Geertruyden, Muhindo Mavoko, Pascal Lutumba, Junior Matangila, Philipe Brasseur, Patrice Piola, Rindra Randremanana, Estrella Lasry, Caterina Fanello, Marie Onyamboko, Birgit Schramm, Zolia Yah, Joel Jones, Rick M. Fairhurst, Mahamadou Diakite, Grace Malenga, Malcolm Molyneux, Claude Rwagacondo, Charles Obonyo, Endalamaw Gadisa, Abraham Aseffa, Mores Loolpapit, Marie-Claire Henry, Grant Dorsey, Chandy John, Sodiomon B. Sirima, Karen I. Barnes, Peter Kremsner, Nicholas P. Day, Nicholas J. White, Mavuto Mukaka
Article
Infectious Diseases
Bernhards Ogutu, Elizabeth Juma, Charles Obonyo, Vincent Jullien, Gwenaelle Carn, Michel Vaillant, Walter Robert John Taylor, Jean-Rene Kiechel
Article
Infectious Diseases
Bernhards R. Ogutu, Kevin O. Onyango, Nelly Koskei, Edgar K. Omondi, John M. Ongecha, Godfrey A. Otieno, Charles Obonyo, Lucas Otieno, Fredrick Eyase, Jacob D. Johnson, Raymond Omollo, Douglas J. Perkins, Willis Akhwale, Elizabeth Juma
Article
Multidisciplinary Sciences
Zulkarnain Md Idris, Chim W. Chan, James Kongere, Jesse Gitaka, John Logedi, Ahmeddin Omar, Charles Obonyo, Beatrice Kemunto Machini, Rie Isozumi, Isao Teramoto, Masatsugu Kimura, Akira Kaneko
SCIENTIFIC REPORTS
(2016)
Article
Public, Environmental & Occupational Health
Tolu Oni, Lisa K. Micklesfield, Pamela Wadende, Charles O. Obonyo, James Woodcock, Ebele R. I. Mogo, Feyisayo A. Odunitan-Wayas, Felix Assah, Lambed Tatah, Louise Foley, Clarisse Mapa-Tassou, Divya Bhagtani, Amy Weimann, Camille Mba, Nigel Unwin, Anna Brugulat-Panes, Karen J. Hofman, Joanne Smith, Marshall Tulloch-Reid, Agnes Erzse, Maylene Shung-King, Estelle V. Lambert, Nicholas J. Wareham
GLOBAL HEALTH ACTION
(2020)
Article
Public, Environmental & Occupational Health
Tolu Oni, Felix Assah, Agnes Erzse, Louise Foley, Ishtar Govia, Karen J. Hofman, Estelle Victoria Lambert, Lisa K. Micklesfield, Maylene Shung-King, Joanne Smith, Eleanor Turner-Moss, Nigel Unwin, Pamela Wadende, James Woodcock, Jean Claude Mbanya, Shane A. Norris, Charles O. Obonyo, Marshall Tulloch-Reid, Nicholas J. Wareham
GLOBALIZATION AND HEALTH
(2020)
Article
Health Care Sciences & Services
Feyisayo A. Odunitan-Wayas, Pamela Wadende, Ebele R. Mogo, Anna Brugulat-Panes, Lisa K. Micklesfield, Ishtar Govia, Clarisse Mapa-Tassou, Gudani Mukoma, Joanne A. Smith, Molebogeng Motlhalhedi, Yves Wasnyo, Vincent Were, Felix Assah, Kufre J. Okop, Shane A. Norris, Charles Obonyo, Jean Claude Mbanya, Marshall K. Tulloch-Reid, Abby C. King, Estelle Lambert, Tolu Oni
Summary: This study protocol focuses on exploring the influences on diet and physical activity behaviors in adolescents from LMICs through a convergent mixed methods design. Data collection has been completed in multiple countries, and the results are expected to be published by 2022, providing valuable insights for improving health outcomes in this population.
JMIR RESEARCH PROTOCOLS
(2021)
Article
Infectious Diseases
Charles O. Obonyo, Elizabeth A. Juma, Vincent O. Were, Bernhards R. Ogutu
Summary: This study found that a 3-day low dose course of quinine plus clindamycin is not effective in treating uncomplicated falciparum malaria in children under 5 years of age in Kenya, where artemether-lumefantrine remains effective.
Article
Nutrition & Dietetics
Elizabeth Olatunji, Charles Obonyo, Pamela Wadende, Vincent Were, Rosemary Musuva, Charles Lwanga, Eleanor Turner-Moss, Matthew Pearce, Ebele R. I. Mogo, Oliver Francis, Louise Foley
Summary: This study explored the relationship between household food source and household food insecurity, individual dietary diversity, and individual body mass index in Western Kenya. The findings suggest that owning livestock and buying food from supermarkets are associated with lower household food insecurity, higher dietary diversity, and a higher likelihood of achieving minimum dietary diversity.
Article
Green & Sustainable Science & Technology
Lambed Tatah, Yves Wasnyo, Matthew Pearce, Tolu Oni, Louise Foley, Ebele Mogo, Charles Obonyo, Jean Claude Mbanya, James Woodcock, Felix Assah
Summary: The literature on urban travel behaviour in Africa is limited, so a telephone survey was conducted to investigate travel behaviour and barriers to active travel in Yaounde, Cameroon. The survey found that most participants reported at least one trip, with shared taxis and walking being the primary modes of transport. Women traveled less frequently and for shorter durations. The main barriers to active travel were fear of road traffic injuries and inconvenience.
Article
Respiratory System
Ju-Wei R. Chang, Fatai M. Akemokwe, Diana M. Marangu, Blessings Chisunkha, Eshiobo Irekpita, Godwin Obasikene, Jacqueline W. Kagima, Charles O. Obonyo
ANNALS OF THE AMERICAN THORACIC SOCIETY
(2020)
Meeting Abstract
Public, Environmental & Occupational Health
Charles O. Obonyo, Elizabeth Juma, Bernhards Oguto
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2015)
Article
Food Science & Technology
M. I. Obade, P. Andang'o, C. Obonyo, F. Lusweti
CURRENT RESEARCH IN NUTRITION AND FOOD SCIENCE
(2015)
