Article
Cell Biology
Ziyi Liu, Xinfeng Bai, Peifeng Wan, Fan Mo, Ge Chen, Jian Zhang, Jiangang Gao
Summary: Research shows that the lack of Loxl3 in the inner ear may lead to hearing loss, hair cell degeneration, and neuronal degeneration, indicating that Loxl3 plays a crucial role in maintaining auditory function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Marijana Sekulic-Jablanovic, Jessica Paproth, Cinzia Sgambato, Giuseppe Albano, Daniel G. Fuster, Daniel Bodmer, Vesna Petkovic
Summary: This study found that the lack or inhibition of NHE6 or NKCC1 affects the permeability of endothelial BLB-derived cells. These findings suggest that NHE6 and NKCC1 could serve as potential targets to modify BLB permeability for drug delivery to the cochlea or to protect the cochlea from ototoxic insults.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Xueling Wang, Jiayi Gu, Ke Xu, Baoying Xu, Dehong Yu, Hao Wu
Summary: This study investigates a novel noninvasive sound conditioning strategy to enhance the permeability of the blood-labyrinth-barrier (BLB) and facilitate drug delivery into the inner ear. The results suggest that the key gene Rab13 plays an inhibitory role in controlling the tight junction and cellular permeability, while transcellular trafficking has little impact. These findings have important implications for clinical medications for hearing loss.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Article
Neurosciences
Marijana Sekulic, Raoul Puche, Daniel Bodmer, Vesna Petkovic
Summary: Hearing loss is a major cause of disability worldwide. Inner ear auditory hair cells and the blood-labyrinth barrier (BLB) play crucial roles in hearing, and BLB defects are associated with various inner ear diseases. TNF-alpha has the most significant effect on the endothelial barrier, while IL6 has a moderate influence and LPS has minimal impact.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Jessica Correa Bezerra Bellei, Nicolas Glanzmann, Barbara Albuquerque Carpinter, Daniela Chaves Renhe, Carolina Brandi Marques, Marina Rocha Azevedo, Livia Maria Barreto, Vinicius Novaes Rocha, Isabelle Karine da Costa Nunes, Henrique Marcelo Gualberto Pereira, Elaine Soares Coimbra, Eduardo Antonio Ferraz Coelho, Adilson David da Silva, Fernando de Pilla Varotti, Kezia Katiani Gorza Scopel
Summary: Chloroquine remains the most effective drug for malaria treatment, although resistance to it has emerged. This study focuses on the synthesis of quinoline derivatives to develop new antimalarials. Compound 3 showed promising activity against malaria, inhibiting parasite growth and protecting against severe malaria development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemical Research Methods
Aleena Das, Welka Sahu, Deepak Kumar Ojha, K. Sony Reddy, Mrutyunjay Suar
Summary: An untargeted metabolomics approach was used to identify the changes in metabolic pathways and metabolites in the serum of mice with different pathological stages of malaria. The study provides insights into the host biology during malaria and could be helpful for the selection of animal models for evaluating diagnostic and therapeutic interventions against malaria.
JOURNAL OF PROTEOME RESEARCH
(2022)
Article
Immunology
Tarun Keswani, Aisha Obeidallah, Edward Nieves, Simone Sidoli, Melissa Fazzari, Terrie Taylor, Karl Seydel, Johanna P. Daily
Summary: This study explored the metabolic etiology of cerebral malaria coma and found abnormal concentrations of pipecolic acid (PA) in the plasma of CM patients, which were associated with renal insufficiency. PA levels were found to be correlated with normal behavior and blood-brain barrier (BBB) permeability in animal models. The findings suggest that malaria-generated PA induces coma in CM and ECM.
JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Immunology
Shweta Rai, Meetali Girdhar, Fouzia Siraj, Sheetal Sharma, Mukesh Kumar, Anju Katyal
Summary: This study aimed to dissect and differentiate the immunopathogenesis of cerebral malaria in young BALB/c and C57BL/6J mice infected with Plasmodium berghei ANKA (PbA), in search of a mouse model mimicking pediatric cerebral malaria. The results showed that young BALB/c mice had a severe course of infection and typical histopathological alterations, such as monocytic plugging, compared to C57BL/6J mice. BALB/c mice also exhibited decreased blood-brain barrier permeability and increased expression of pro/anti-inflammatory cytokines. These findings suggest that the imbalance of cytokine expression contributes to the worsening of disease manifestation in young BALB/c mice, similar to pediatric cerebral malaria.
IMMUNOLOGY LETTERS
(2023)
Article
Immunology
Takashi Imai, Ha Ngo-Thanh, Kazutomo Suzue, Aoi Shimo, Akihiro Nakamura, Yutaka Horiuchi, Hajime Hisaeda, Takashi Murakami
Summary: This study aims to develop a malaria vaccine that provides cross-strain protection. Results showed that inoculation of mice with a heterologous live-vaccine prevented the development of experimental cerebral malaria (ECM) and protected the blood-organ barriers from infection. The immune response induced by the live vaccine included cross-reactive antibodies and IL-10-mediated host protection against ECM.
Article
Immunology
A. Galan-Salinas, G. Corral-Ruiz, M. J. Perez-Vega, L. Fabila-Castillo, R. Silva-Garcia, B. Marquina-Castillo, J. C. Leon-Contreras, J. Barrios-Payan, A. Francisco-Cruz, M. Montecillo-Aguado, S. Huerta-Yepez, J. Calderon-Amador, L. Flores-Romo, R. Hernandez-Pando, L. E. Sanchez-Torres
Summary: The study demonstrated that the administration of anti-inflammatory peptide MLIF increased survival and provided neuroprotection in murine cerebral malaria by reducing neuroinflammation, inhibiting cell adhesion, and maintaining blood-brain barrier integrity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Integrative & Complementary Medicine
Karen Renata Herculano Matos Oliveira, Marjorie Lujan Marques Torres, Nayara Kauffmann, Brenda Jaqueline de Azevedo Ataide, Nivia de Souza Franco Mendes, Larissa Medeiros dos Anjos, Rosivaldo dos Santos Borges, Carlomagno Pacheco Bahia, Luana Ketlen Reis Leao, Adelaide da Conceicao Fonseca Passos, Anderson Manoel Herculano, Evander de Jesus Oliveira Batista
Summary: Diet enriched with acai can provide neuroprotection during the development of experimental cerebral malaria.
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2022)
Article
Surgery
Lisa M. H. de Pont, Josephine M. van Steekelenburg, Thijs O. Verhagen, Maartje Houben, Jelle J. Goeman, Berit M. Verbist, Mark A. van Buchem, Claire C. Bommelje, Henk M. Blom, Sebastiaan Hammer
Summary: The degree of endolymphatic hydrops (EH) positively correlates with disease duration, hearing loss severity, and the incidence of drop attacks. Perilymphatic enhancement is commonly present in unilateral EH patients. The signal intensity ratio (SIR) increases with hydrops grade but is not significantly correlated with low or high-frequency hearing loss.
FRONTIERS IN SURGERY
(2021)
Review
Immunology
Nana Efua Andoh, Ben Adu Gyan
Summary: Cerebral malaria is a severe neurological complication caused by Plasmodium falciparum parasite, mainly affecting children under 5 years in Sub-Saharan Africa. Glial cells play potential roles in the pathogenesis of cerebral malaria and may contribute to neurological damage in CM patients.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Ya Tian, Zhongyuan Zheng, Xi Wang, Shuzhi Liu, Liwei Gu, Jing Mu, Xiaojun Zheng, Yujie Li, Shuo Shen
Summary: Cerebral malaria is a life-threatening neurological complication caused by Plasmodium falciparum. Current treatments using artemisinin and its derivatives are not effective in targeting the brain. This study explored a new approach by using a brain-targeted nano-delivery system. The results showed that the brain-targeted liposomes had a higher fluorescence intensity in the mouse brain and improved treatment outcomes. Pharmacokinetic analysis demonstrated that the brain-targeted liposomes could enter the brain through both systemic circulation and nasal-brain pathway. This research provides valuable insights for the treatment of cerebral malaria.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Article
Audiology & Speech-Language Pathology
Ayesha Noman, Subhendu Mukherjee, Trung N. Le
Summary: The study demonstrates that mannitol can increase the permeability of the blood labyrinth barrier, facilitating the entry of cisplatin and otoprotective agents. Delayed mannitol injection reduces cisplatin-induced hearing loss and enhances the efficacy of antioxidants in protecting the ear.
Article
Cell Biology
Lejo Johnson Chacko, Consolato Sergi, Theresa Eberharter, Jozsef Dudas, Helge Rask-Andersen, Romed Hoermann, Helga Fritsch, Natalie Fischer, Rudolf Glueckert, Anneliese Schrott-Fischer
CELL AND TISSUE RESEARCH
(2020)
Article
Endocrinology & Metabolism
Alberto Addis, Maxime Gaasch, Alois J. Schiefecker, Mario Kofler, Bogdan Ianosi, Verena Rass, Anna Lindner, Gregor Broessner, Ronny Beer, Bettina Pfausler, Claudius Thome, Erich Schmutzhard, Raimund Helbok
Summary: Elevated brain temperature (T-brain) exceeding core body temperature is associated with better metabolic state and improved outcome, suggesting that ΔT may serve as a surrogate marker for brain function and predict clinical course and outcome after subarachnoid hemorrhage (SAH).
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Clinical Neurology
Andrew P. Carlson, Daniel Haenggi, George K. Wong, Nima Etminan, Stephan A. Mayer, Francois Aldrich, Michael N. Diringer, Erich Schmutzhard, Herbert J. Faleck, David Ng, Benjamin R. Saville, Thomas Bleck, Robert Grubb, Michael Miller, Jose I. Suarez, Howard M. Proskin, R. Loch Macdonald
Letter
Clinical Neurology
Andrea Sylvia Winkler, Samuel Knauss, Erich Schmutzhard, Matilde Leonardi, Alessandro Padovani, Foad Abd-Allah, Augustina Charway-Felli, Julius Valentin Emmerich, Thirugnanam Umapathi, Parthasarthy Satishchandra, Fan Kee Hoo, Josep Dalmau, Celia Oreja-Guevara, Lucia Brito Ferreira, Bettina Pfausler, Benedict Michael, Fabrizio Tagliavini, Gunter Hoglinger, Matthias Endres, Christine Klein, Bernhard Hemmer, William Correll, James Sejvar, Tom Solomon
Article
Critical Care Medicine
Anna Lindner, Verena Rass, Bogdan-Andrei Ianosi, Alois J. Schiefecker, Mario Kofler, Paul Rhomberg, Bettina Pfausler, Ronny Beer, Erich Schmutzhard, Claudius Thome, Raimund Helbok
Summary: The location of PbtO2 probes in ICH patients significantly affects brain tissue oxygen tension levels and pathophysiological status. Brain tissue hypoxia is more common in perilesional area, and targeted treatment interventions in this area may help improve the condition.
NEUROCRITICAL CARE
(2021)
Article
Public, Environmental & Occupational Health
Dominik Stelzle, Corinna Storz, Arlette Baxmann, Linda A. Liang, Clemens Burtscher, William Matuja, Erich Schmutzhard, Andrea S. Winkler
Summary: The cumulative incidence of febrile seizures in an urban Tanzanian population was similar to rates in rural populations. Most cases occurred before the age of two, with around 80% of children experiencing multiple episodes, and a large proportion of cases were complex febrile seizures often associated with malaria or respiratory infections.
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2021)
Article
Critical Care Medicine
Fabian Reimann, Thomas Rinner, Anna Lindner, Mario Kofler, Bogdan-Andrei Ianosi, Alois Josef Schiefecker, Ronny Beer, Erich Schmutzhard, Bettina Pfausler, Raimund Helbok, Verena Rass
Summary: The study investigated the risk factors and impact of hyperactive delirium in SAH patients. Mechanical ventilation over 48 hours, detection of an aneurysm, lower Hunt&Hess grade, and pre-treated psychiatric disorder were associated with delirium development. Overall, delirium was not associated with worse outcome, but patients with delirium often had intermediate outcomes based on modified Rankin Scale Score.
JOURNAL OF CRITICAL CARE
(2021)
Article
Critical Care Medicine
Verena Rass, Anna Lindner, Bogdan-Andrei Ianosi, Alois Josef Schiefecker, Sebastian Loveys, Mario Kofler, Sofia Rass, Bettina Pfausler, Ronny Beer, Erich Schmutzhard, Raimund Helbok
Summary: The study identified that factors such as intraventricular hemorrhage, prolonged QRS complex, and female sex were associated with higher heart rate variability in the acute phase after spontaneous intracerebral hemorrhage (ICH). A higher heart rate variability in the acute phase was found to be related to poor 3-month outcome in ICH patients.
JOURNAL OF CRITICAL CARE
(2021)
Editorial Material
Clinical Neurology
Erich Schmutzhard
CURRENT OPINION IN NEUROLOGY
(2021)
Article
Clinical Neurology
Anna Lindner, Verena Rass, Bogdan-Andrei Ianosi, Alois Josef Schiefecker, Mario Kofler, Max Gaasch, Alberto Addis, Paul Rhomberg, Bettina Pfausler, Ronny Beer, Erich Schmutzhard, Claudius Thome, Raimund Helbok
Summary: This study aimed to define the optimal SBP range for ICH patients after hematoma evacuation (HE) based on multimodal neuromonitoring data. The results showed that lower SBP and CPP levels are associated with a higher risk for brain tissue hypoxia (BTH). Further studies are needed to evaluate whether a higher SBP target may prevent BTH and improve outcomes.
JOURNAL OF NEUROSURGERY
(2021)
Article
Critical Care Medicine
Raimund Helbok, Verena Rass, Mario Kofler, Heribert Talasz, Alois Schiefecker, Max Gaasch, Christoph Scherfler, Bettina Pfausler, Claudius Thome, Ronny Beer, Herbert H. Lindner, Erich Schmutzhard
Summary: This study found that iron accumulates in the cerebral white matter of patients with severe SAH, and iron levels may be associated with disease progression and neurologic metabolic abnormalities.
NEUROCRITICAL CARE
(2022)
Article
Biochemistry & Molecular Biology
Lejo Johnson Chacko, Hanae Lahlou, Claudia Steinacher, Said Assou, Yassine Messat, Jozsef Dudas, Albert Edge, Berta Crespo, Moira Crosier, Consolato Sergi, Anneliese Schrott-Fischer, Azel Zine
Summary: By analyzing transcriptomic data from otic sensory cells differentiated from human induced pluripotent stem cells, we identified novel genes and biological networks in the human otic sensory developmental cell lineage. The study suggests a critical role of ECM-ITG interactions with otic neurosensory lineage genes in early neurosensory development and cell fate determination in the human fetal inner ear.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Multidisciplinary Sciences
Timo M. Gottfried, Daniel Dejaco, Natalie Fischer, Veronika Innerhofer, Lejo Johnson Chacko, Gerlig Widmann, Christian Kremser, Herbert Riechelmann, Joachim Schmutzhard
Summary: This study investigates the impact of cochlear implants (CIs) on MRI image quality and artifacts. MRI scans were performed on a model and patients with CIs, and the resulting artifacts were compared. The study found that CIs do affect MRI image quality and cause varying artifacts depending on the sequence used.
SCIENTIFIC REPORTS
(2022)
Article
Otorhinolaryngology
Daniel Dejaco, David Riedl, Timo Maria Gottfried, Matthias Santer, Annette Runge, Josef Seebacher, Philipp Zelger, Bicego Lia, Schmutzhard Joachim
Summary: This study investigates the influence of intraoperative ABR measurements and various fixation methods on postoperative coupling quality in Vibroplasty surgery, and finds that intraoperative ABR measurement can significantly improve the coupling quality after the surgery.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Neurosciences
Maria Luque, Anneliese Schrott-Fischer, Jozsef Dudas, Elisabeth Pechriggl, Erich Brenner, Helge Rask-Andersen, Wei Liu, Rudolf Glueckert
Summary: Neuronal diversity in the cochlea is largely influenced by ion channels, particularly the HCN channels which play a crucial role in auditory function. Studying the expression levels and spatial distribution of HCN subunits across different mammalian species can provide insights into age-related hearing deterioration mechanisms and potentially offer solutions for hearing impairments.
JOURNAL OF NEUROSCIENCE RESEARCH
(2021)