Article
Immunology
Camille Roussel, Papa Alioune Ndour, Eric Kendjo, Sebastien Larreche, Aida Taieb, Benoit Henry, Benedicte Lebrun-Vignes, Charlotte Chambrion, Nicolas Argy, Sandrine Houze, Oussama Mouri, David Courtin, Adela Angoulvant, Herve Delacour, Frederick Gay, Jean-Yves Siriez, Martin Danis, Fabrice Bruneel, Olivier Bouchaud, Eric Caumes, Renaud Piarroux, Marc Thellier, Stephane Jaureguiberry, Pierre Buffet
Summary: This study investigated the use of intravenous artesunate in 1391 patients with severe imported malaria in France from 2011 to 2017, finding that artesunate was widely used, effective, but with a high incidence of adverse events such as anemia and cardiac events. Further exploration should focus on outcomes during pregnancy and rare but potentially severe cardiac adverse events in the context of imported malaria.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Health Care Sciences & Services
Mariangela Martino, Cecilia Liberati, Benedetta Bua, Elisa Barbieri, Paola Costenaro, Costanza Di Chiara, Carlo Giaquinto, Ettore De Canale, Osvalda Rampon, Daniele Dona
Summary: This article discusses post-artesunate delayed haemolysis and neutropenia as potential adverse reactions after treatment with artesunate for severe malaria. Through literature review, these two side effects were also found to occur in children. While the benefits of artesunate outweigh its side effects, hematological follow-up is still necessary to avoid potential complications.
Article
Infectious Diseases
Annarita Botta, Agnese Comelli, Iacopo Vellere, Flavia Chechi, Leila Bianchi, Gardini Giulia, Lina Rachele Tomasoni, Michele Spinicci, Luisa Galli, Francesco Castelli, Alessandro Bartoloni, Lorenzo Zammarchi
Summary: A retrospective cohort study compared the effects of IVA + IVQ and IVA treatment for imported severe malaria and found that IVA + IVQ treatment did not show better outcomes and had more adverse events in adults. Further research is needed to investigate whether IVA + IVQ could be an effective strategy in areas with high artemisinin resistance.
Review
Immunology
Christine M. Thomas, William M. Stauffer, Jonathan D. Alpern
Summary: Intravenous artesunate is now available for the treatment of severe malaria in the US. We propose a hospital tier framework to guide the decision of stocking this drug.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Public, Environmental & Occupational Health
Federica Agagliati, Erika Silvestro, Marco Denina, Silvia Garazzino, Federica Mignone, Marisa Zoppo, Giulia Pruccoli, Carlo Scolfaro
Summary: Malaria is not endemic in Italy, but about 600-700 imported cases are detected every year in people born or living in Italy who return from their country of origin. Children, accounting for 20% of this population, are more at risk of severe malaria. Lack of awareness of the importance of prophylaxis due to socio-economic problems and deficiencies in the doctor-patient relationship make the VFR category at increased risk. This study aims to analyze the characteristics of pediatric imported malaria, focusing on prevention and risk factors for severe malaria.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2022)
Review
Infectious Diseases
M. Bonsergent, M. Tching-Sin, S. Honore, P. Bertault-Peres, A. Lepelletier, L. Flet, T. Perez
Summary: This study assessed the real-life effectiveness and safety of intravenous artesunate (AS) in the treatment of severe imported malaria (SIM) in two hospitals in France. The study found that AS demonstrated good efficacy and safety in non-endemic areas. Accelerated administrative procedures are needed to obtain full registration and facilitate access to AS in France.
BMC INFECTIOUS DISEASES
(2023)
Editorial Material
Immunology
Jonathan S. Schultz, Kimberly E. Mace, Kathrine R. Tan
Summary: The increase in international travel during the COVID-19 pandemic recovery period is expected to lead to an increase in imported malaria cases in the US. Prevention, timely diagnosis, and appropriate treatment are crucial in minimizing imported malaria morbidity and mortality. Intravenous artesunate (IVAS) is now available for severe malaria treatment in the US. Hospitals and pharmacists should have a malaria treatment plan that includes stocking artemether-lumefantrine for uncomplicated malaria and ensuring access to IVAS for severe cases.
CLINICAL INFECTIOUS DISEASES
(2023)
Editorial Material
Public, Environmental & Occupational Health
Wasin Matsee, Thanyapat Hiranrusme, Phimphan Pisutsan, Borimas Hanboonkunupakarn, Kesinee Chotivanich
Summary: The article discusses the risk of delayed hemolysis in travelers to endemic areas of malaria, and advises clinicians to pay close attention to this phenomenon in order to prevent potential risks.
JOURNAL OF TRAVEL MEDICINE
(2021)
Article
Immunology
Francisca Abanyie, Joanna Ng, Kathrine R. Tan
Summary: This study describes the prevalence and outcomes of post-artesunate delayed hemolysis (PADH) events among severe malaria cases treated with intravenous artesunate (IVAS) in the United States. PADH is an uncommon and self-limiting adverse event, with most cases being diagnosed within 2 weeks after initiation of IVAS. Some cases require blood transfusions but all recover without sequelae.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
James A. Watson, Thomas J. Peto, Nicholas J. White
Summary: CARAMAL is a large observational study conducted in Nigeria, Uganda, and the Democratic Republic of the Congo, which recorded mortality in children with suspected severe malaria. The study's results have had a significant impact on public health policy leading to a World Health Organization moratorium on the roll-out of rectal artesunate. However, we argue that the causal interpretation of the study results is not justified and that the data primarily inform on the strengths and weaknesses of referral systems in these three countries, rather than reliably informing on the beneficial effect of providing access to a known life-saving treatment.
Article
Public, Environmental & Occupational Health
L. Balerdi-Sarasola, C. Parolo, P. Fleitas, A. Cruz, C. Subira, N. Rodriguez-Valero, A. Almuedo-Riera, L. Letona, M. J. Alvarez-Martinez, M. Eugenia Valls, I. Vera, A. Mayor, J. Munoz, D. Camprubi-Ferrer
Summary: This study found that combining Ang-2 and CRP can effectively identify severe imported malaria in the early stages by measuring biomarkers in patients' blood. The use of a rapid prognostic test including these biomarkers has the potential to optimize the management of imported malaria and reduce complications and hospitalization rates.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2023)
Article
Infectious Diseases
Sophie Landre, Anne-Lise Bienvenu, Patrick Miailhes, Paul Abraham, Marie Simon, Agathe Becker, Anne Conrad, Guillaume Bonnot, Yobouet Ines Kouakou, Christian Chidiac, Gilles Leboucher, Thomas Rimmele, Laurent Argaud, Stephane Picot
Summary: A patient with severe malaria and hyperparasitaemia was initially treated with 7-day artesunate monotherapy, which led to a severe recrudescence due to hyperparasitaemia, monotherapy, and a polyclonal infection without Kelch 13 gene mutation. Subsequent treatments with artesunate, quinine, and artemether-lumefantrine were successful in curing the patient.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Immunology
Francisca Abanyie, Sushama D. Acharya, Isabelle Leavy, Meara Bowe, Kathrine R. Tan
Summary: This study investigated the safety and effectiveness of IVAS for the treatment of severe malaria in the United States. The results showed that IVAS is a safe and effective drug, and timely administration can be lifesaving.
CLINICAL INFECTIOUS DISEASES
(2021)
Article
Biology
James A. Watson, Carolyne M. Ndila, Sophie Uyoga, Alexander Macharia, Gideon Nyutu, Shebe Mohammed, Caroline Ngetsa, Neema Mturi, Norbert Peshu, Benjamin Tsofa, Kirk Rockett, Stije Leopold, Hugh Kingston, Elizabeth C. George, Kathryn Maitland, Nicholas P. J. Day, Arjen M. Dondorp, Philip Bejon, Thomas Williams, Chris C. Holmes, Nicholas J. White
Summary: Severe falciparum malaria has significant impact on human evolution, but genetic susceptibility studies are limited by phenotypic imprecision. Diagnostic uncertainty in young children in high malaria transmission areas prompted the development of a probabilistic diagnostic model, improving accuracy. The proposed data-tilting approach in case-control studies with phenotype mis-labeling can reduce false discovery rates and enhance statistical power in genetic association studies.
Article
Multidisciplinary Sciences
Ketsanee Srinamon, James A. Watson, Kamolrat Silamut, Benjamas Intharabut, Nguyen Hoan Phu, Pham Thi Diep, Kirsten E. Lyke, Caterina Fanello, Lorenz von Seidlein, Kesinee Chotivanich, Arjen M. Dondorp, Nicholas P. J. Day, Nicholas J. White
Summary: Malaria diagnosis by microscopy is crucial for clinical management, providing rapid and valuable diagnostic and prognostic information. In this meta-analysis, the authors examined the diagnostic and prognostic value of polymorphonuclear leukocytes and monocytes containing malaria pigment in peripheral blood film counts of severe malaria patients. They found that the proportion of pigment-containing polymorphonuclear leukocytes can predict in-hospital mortality, especially in African children, aiding in differentiating severe malaria from other life-threatening febrile illnesses.
NATURE COMMUNICATIONS
(2022)
Article
Dermatology
Helmut J. F. Salzer, Jan Heyckendorf, Barbara Kalsdorf, Thierry Rolling, Christoph Lange
Article
Medicine, General & Internal
Matthias Raspe, Anja Vogelgesang, Johannes Fendel, Cornelius Weiss, Kevin Schulte, Thierry Rolling
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2018)
Editorial Material
Medicine, General & Internal
Christof D. Vinnemeier, Thierry Rolling
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2018)
Letter
Respiratory System
Jan Heyckendorf, Frank van Leth, Barbara Kalsdorf, Ioana D. Olaru, Gunar Gunther, Helmut J. F. Salzer, Elena Terhalle, Thierry Rolling, Georg Glattki, Marius Mueller, Maren Schuhmann, Korkut Avsar, Christoph Lange
EUROPEAN RESPIRATORY JOURNAL
(2018)
Article
Infectious Diseases
J. Heyckendorf, F. van Leth, K. Avsar, G. Glattki, G. Guenther, B. Kalsdorf, M. Mueller, I. D. Olaru, T. Rolling, H. J. F. Salzer, M. Schuhmann, E. Terhalle, C. Lange
INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
(2018)
Article
Public, Environmental & Occupational Health
Helmut J. F. Salzer, Rhett J. Stoney, Kristina M. Angelo, Thierry Rolling, Martin P. Grobusch, Michael Libman, Rogelio Lopez-Velez, Alexandre Duvignaud, Hilmir Asgeirsson, Clara Crespillo-Andujar, Eli Schwartz, Philippe Gautret, Emmanuel Bottieau, Sabine Jordan, Christoph Lange, Davidson H. Hamer
JOURNAL OF TRAVEL MEDICINE
(2018)
Review
Respiratory System
Helmut J. F. Salzer, Gerd Burchard, Oliver A. Cornely, Christoph Lange, Thierry Rolling, Stefan Schmiedel, Michael Libman, Domenico Capone, Thuy Le, Margareth P. Dalcolmo, Jan Heyckendorf
Article
Infectious Diseases
Klara Sonden, Thierry Rolling, Andreas Wangdahl, Elsie Ydring, Sabine Vygen-Bonnet, Robert Kobbe, Johan Douhan, Ulf Hammar, Janneke Duijster, Brechje de Gier, Joanne Freedman, Nicole Gysin, Klaus Stark, Flora Stevens, Lasse Skafte Vestergaard, Anders Tegnell, Anna Farnert
Article
Infectious Diseases
Andreas M. Froelich, Pinkus Tober-Lau, Michael Schoenfeld, Thomas T. Brehm, Florian Kurth, Christof D. Vinnemeier, Marylyn M. Addo, Jens Fiehler, Thierry Rolling
Review
Medicine, General & Internal
Matthias Raspe, Thierry Rolling, Charlotte Leisse, Julia Fischer, Clara Lehmann
DEUTSCHE MEDIZINISCHE WOCHENSCHRIFT
(2019)
Article
Biochemistry & Molecular Biology
Bing Zhai, Mihaela Ola, Thierry Rolling, Nicholas L. Tosini, Sari Joshowitz, Eric R. Littmann, Luigi A. Amoretti, Emily Fontana, Roberta J. Wright, Edwin Miranda, Charlotte A. Veelken, Sejal M. Morjaria, Jonathan U. Peled, Marcel R. M. van den Brink, N. Esther Babady, Geraldine Butler, Ying Taur, Tobias M. Hohl
Article
Biochemistry & Molecular Biology
Elizabeth V. Robilotti, N. Esther Babady, Peter A. Mead, Thierry Rolling, Rocio Perez-Johnston, Marilia Bernardes, Yael Bogler, Mario Caldararo, Cesar J. Figueroa, Michael S. Glickman, Alexa Joanow, Anna Kaltsas, Yeon Joo Lee, Anabella Lucca, Amanda Mariano, Sejal Morjaria, Tamara Nawar, Genovefa A. Papanicolaou, Jacqueline Predmore, Gil Redelman-Sidi, Elizabeth Schmidt, Susan K. Seo, Kent Sepkowitz, Monika K. Shah, Jedd D. Wolchok, Tobias M. Hohl, Ying Taur, Mini Kamboj
Article
Infectious Diseases
Melina Heinemann, Richard O. Phillips, Christof D. Vinnemeier, Christina C. Rolling, Egbert Tannich, Thierry Rolling
Article
Microbiology
Thierry Rolling, Bing Zhai, Mergim Gjonbalaj, Nicholas Tosini, Keiko Yasuma-Mitobe, Emily Fontana, Luigi A. Amoretti, Roberta J. Wright, Doris M. Ponce, Miguel A. Perales, Joao B. Xavier, Marcel R. M. van den Brink, Kate A. Markey, Jonathan U. Peled, Ying Taur, Tobias M. Hohl
Summary: Analysis of intestinal microbiota in patients undergoing allogeneic haematopoietic cell transplantation revealed an association between fungal dysbiosis, expansion of Candida parapsilosis complex species and worse patient outcomes. Specific patients with fungal dysbiosis, characterized by stable expansion of Candida parapsilosis complex species, had lower overall survival and higher transplant-related mortality. Targeting fungal dysbiosis may improve long-term patient survival outcomes.
NATURE MICROBIOLOGY
(2021)
Article
Medicine, Research & Experimental
Thierry Rolling, Bing Zhai, John Frame, Tobias M. Hohl, Ying Taur
Summary: Identification and analysis of fungal communities commonly rely on ITS-based amplicon sequencing. In this study, a customized DADA2-based pipeline was used to achieve high-resolution inference of fungal constituents. Quality filtering, sequencing bias, and database selection were identified as key variables determining the accuracy of sample inference. By fine-tuning the filtering process and introducing a wobble nucleotide, the representation of fungal communities was improved. Additionally, a BLAST-based algorithm showed higher reliability in species-level taxonomic annotation compared with the naive Bayesian classifier implemented in DADA2.