Article
Medicine, General & Internal
Ipsita Pal Bhowmick, Apoorva Pandey, Sarala K. Subbarao, Rocky Pebam, Tapan Majumder, Aatreyee Nath, Diptarup Nandi, Analabha Basu, Apurba Sarkar, Saikat Majumder, Jotish Debbarma, Dipanjan Dasgupta, Arup Borgohain, Rajdeep Chanda, Mandakini Das, Karuna Gogoi, Kongkona Gogoi, Pyare Laal Joshi, Harpreet Kaur, Biswajyoti Borkakoti, Dibya Ranjan Bhattacharya, Abdul Mamood Khan, Satyajit Sen, Kanwar Narain
Summary: The aetiology of non-malaria vector-borne diseases in a malaria-endemic area in north-east India was studied for the first time. The study revealed the presence of dengue, Japanese encephalitis, chikungunya, scrub typhus, and leptospirosis in the region. The prevalence of these diseases was found to be associated with age. The study highlights the need for improved diagnostic procedures and the development of rapid diagnostic protocols for rural hospitals and community fever surveillance.
Article
Multidisciplinary Sciences
Richard Okyere Boadu, Hor Karimeni Karimu, Kwame Adu Okyere Boadu, Obed Uwumbornyi Lasim, Lady Agyei Boatemaa, Solomon Abotiba Atinbire, Nathan Kumasenu Mensah
Summary: This study analyzes the data quality of Routine Health Information Systems (RHIS) in the Sissala East Municipal Health Directorate (MHD) regarding proficiency, timeliness, availability, and accuracy. The majority of health staff members had not received training on malaria-related RHIS and lacked proficiency in malaria indicators. Although timeliness of reporting was below the target, data completeness and availability were achieved. The study emphasizes the need for training, supervision, and monitoring to improve staff proficiency and data quality.
Article
Public, Environmental & Occupational Health
Lili Wang, Jianhai Yin, Canjun Zheng, Samuel Juana Smith, Esther Ngegba, Xiaoxia Huang, Anitta Kamara, Xia Chen, Xu Wang, Wei Luo, Biao Kan
Summary: The study conducted in three communities in Sierra Leone's Western Rural District revealed high public awareness of malaria prevention, but limited use of preventive measures in these areas, leading to a continued high malaria burden.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Multidisciplinary Sciences
Adam Konrad Asghar, Thandaza Cyril Nkabinde, Mergan Naidoo
Summary: This study found that Caesarean delivery in rural primary healthcare settings carries a higher risk of maternal and neonatal complications. Adequate precautions need to be taken to ensure that obstetric services are provided to patients in as safe a manner as possible in this environment.
Article
Pediatrics
Christina W. Obiero, Neema Mturi, Salim Mwarumba, Moses Ngari, Charles Newton, Michael Boele van Hensbroek, James Alexander Berkley
Summary: Detection of meningitis in young infants remains challenging, with WHO-recommended signs showing limited sensitivity and specificity. History of fever improves sensitivity but reduces specificity, highlighting the need for careful evaluation and appropriate diagnostic tools for management.
ARCHIVES OF DISEASE IN CHILDHOOD
(2021)
Article
Cardiac & Cardiovascular Systems
Matthew F. Mikulski, Andrew Well, Daniel Shmorhun, Charles D. Fraser, Carlos M. Mery, Arnold L. Fenrich
Summary: This study analyzed the pacing and outcomes of neonatal congenital atrioventricular block (nCAVB) with and without congenital heart disease (CHD) using a multicenter database. The results showed that the in-hospital mortality rate was 36.2% for nCAVB patients with CHD and 8.4% for those without CHD. Pacemaker placement was associated with a decreased mortality rate.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2023)
Article
Infectious Diseases
Dominique E. Earland, Albino Francisco Bibe, Anisio Novela, Joao Ferrao, Kelly M. Searle
Summary: This study investigated the community-level prevalence of Plasmodium falciparum and health-seeking behaviors among residents in a rural village in Mozambique. The results showed that in a high transmission setting, a high proportion of participants recognized malaria symptoms and sought care in health facilities, where they received proper diagnosis and treatment.
Article
Pediatrics
Bryanna N. Schwartz, Lisa A. Hom, Isabelle Von Kohorn, Jeffrey Becker, Sandra S. Cuzzi, Sue Ellin Grier Clarke, Sharon C. Kiernan, Gerard R. Martin
Summary: The study evaluated newborn pulse oximetry screening outcomes at a large community hospital and the impact of the recommended revised screening algorithm. Results showed that pulse oximetry screening is an effective tool for identifying critical congenital heart disease and other conditions.
Article
Medicine, General & Internal
Chih-Hung Lee, Chu-Chen Huang, Jui-Ting Huang, Chih-Chi Wang, Sheng Fan, Pi-sheng Wang, Kuo-Chung Lan
Summary: Telemedicine is becoming increasingly important in developed countries to address population aging and unequal access to healthcare. In Taiwan, the legal implementation of teledermatology has shown promising results at Kaohsiung Chang Gung Memorial Hospital, improving patient outcomes and case closure rates. The use of teledermatology is anticipated to benefit underserved regions, nursing homes, prisons, and in situations with severe pandemic infections, such as COVID-19.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2021)
Article
Cardiac & Cardiovascular Systems
Astrid Elisabeth Lammers, Gerhard-Paul Diller, Rieke Lober, Mareike Moellers, Renate Schmidt, Robert M. Radke, Fernando De-Torres-Alba, Gerrit Kaleschke, Ursula Marschall, Ulrike M. Bauer, Joachim Gerss, Dominic Enders, Helmut Baumgartner
Summary: This population-based study reveals a reassuringly low maternal mortality rate in a highly developed healthcare system. However, maternal and neonatal morbidity/mortality were significantly increased in women with adult congenital heart disease (ACHD) and their offspring compared to non-ACHD controls, highlighting the importance of specialized care and pre-pregnancy counseling.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Astrid Elisabeth Lammers, Gerhard-Paul Diller, Rieke Lober, Mareike Moellers, Renate Schmidt, Robert M. Radke, Fernando De-Torres-Alba, Gerrit Kaleschke, Ursula Marschall, Ulrike M. Bauer, Joachim Gerss, Dominic Enders, Helmut Baumgartner
Summary: This population-based study revealed a reassuringly low maternal mortality rate in a highly developed healthcare system. However, maternal morbidity and neonatal morbidity/mortality were significantly increased in women with ACHD and their offspring compared to non-ACHD controls, highlighting the need for specialized care and pre-pregnancy counselling.
EUROPEAN HEART JOURNAL
(2021)
Article
Public, Environmental & Occupational Health
Francois Hakizayezu, Jared Omolo, Emmanuel Biracyaza, Joseph Ntaganira
Summary: Malaria is a significant public health burden in Rwanda, leading to high morbidity and mortality. This study identified factors associated with deaths among patients with severe malaria, providing evidence-based interventions for prevention.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Pediatrics
Gill Verstappen, Ina Foulon, Kelsey van den Houte, Emilie Heuninck, Bart Van Overmeire, Frans Gordts, Vedat Topsakal
Summary: This study aimed to assess the different etiologies, risk factors, and hearing results of infants with permanent hearing loss, as well as evaluate the efficacy and consequences of different screening devices over the past 21 years. The results showed that only a limited number of infants had permanent hearing loss, with genetic causes and anatomical abnormalities being the common etiologies for bilateral and unilateral sensorineural hearing loss, respectively.
FRONTIERS IN PEDIATRICS
(2023)
Article
Multidisciplinary Sciences
Antonio Reguera-Teba, Isidro Martinez-Casas, Pablo Torne-Poyatos, Pedro Hernandez-Cortes
Summary: This study focuses on the epidemiology and prognostic factors of injuries caused by fighting bulls in Spain, Portugal, and southern France. The most common mechanism of trauma is goring, with thigh and groin being the most frequent locations. Vascular lesions, head trauma, fractures, goring injuries, and age are significant prognostic factors for severity, while vascular lesions and back gorings are the most reliable prognostic factors for mortality.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Jessica Ashiakie Tetteh, Patrick Elorm Djissem, Alfred Kwesi Manyeh
Summary: This study in the Shai-Osudoku District Hospital, Ghana, found that factors such as age, sex, residential status, religious affiliation, occupation, and marital status influence malaria infection. The findings showed that malaria remains a serious public health problem in this hospital. The information obtained from this study can guide the implementation of malaria prevention, control, and elimination strategies in Ghana.
Article
Clinical Neurology
Jonathan A. Abuga, Symon M. Kariuki, Amina Abubakar, Christopher Nyundo, Samson M. Kinyanjui, Michael Boele Van Hensbroek, Charles Rjc Newton
Summary: The study found a decrease in the overall prevalence of neurological impairments from 2001 to 2015, with significant changes in the associations with some risk factors. There was little geographical variation, indicating that similar interventions are suitable across the defined area.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2022)
Article
Clinical Neurology
Chahnez Charfi Triki, Matilde Leonardi, Salma Zouari Mallouli, Martina Cacciatore, Kimberly Coard Karlshoej, Francesca Giulia Magnani, Charles R. Newton, Andrea Pilotto, Deanna Saylor, Erica Westenberg, Donna Walsh, Andrea Sylvia Winkler, Kiran T. Thakur, Njideka U. Okubadejo, David Garcia-Azorin
Summary: The COVID-19 pandemic has disrupted neurological services to varying degrees globally, with cross-sectoral neurological services and neurorehabilitation being the most affected. Government directives were the major cause of service disruption, with most mitigation strategies established through telemedicine. The survey also found significant impacts on neurological research and educational activities.
JOURNAL OF NEUROLOGY
(2022)
Review
Clinical Neurology
Churl-Su Kwon, Ryan G. Wagner, Arturo Carpio, Nathalie Jette, Charles R. Newton, David J. Thurman
Summary: This article systematically reviews worldwide studies of the epilepsy treatment gap (ETG) and provides recommendations for an updated International League Against Epilepsy (ILAE) definition of ETG. The study found that the definitions and reported ETGs varied widely, highlighting the need for a standardized definition to compare levels of unmet epilepsy care across different countries and regions.
Article
Medicine, General & Internal
Gerard Bryan Gonzales, James M. Njunge, Bonface M. Gichuki, Bijun Wen, Moses Ngari, Isabel Potani, Johnstone Thitiri, Debby Laukens, Wieger Voskuijl, Robert Bandsma, Jill Vanmassenhove, James A. Berkley
Summary: This study explored the roles of albumin and albumin-independent mechanisms in edema formation among children with severe malnutrition. The results showed that edema formation has both albumin-dependent and independent mechanisms, with extracellular matrix integrity playing a greater role than endothelial glycocalyx shedding in severe malnutrition.
Editorial Material
Pediatrics
Moses M. Ngari, James A. Berkley
LANCET CHILD & ADOLESCENT HEALTH
(2022)
Article
Immunology
Alice Kamau, Moses Musau, Stella Mwakio, David Amadi, Amek Nyaguara, Philip Bejon, Anna C. Seale, James A. Berkley, Robert W. Snow
Summary: In an area with high levels of sulfadoxine-pyrimethamine (SP) resistance on the Kenyan coast, intermittent preventive treatment for pregnant women with SP continues to be associated with a reduced risk of low birthweight deliveries and stillbirths.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Kirkby D. Tickell, Donna M. Denno, Ali Saleem, Asad Ali, Zaubina Kazi, Benson O. Singa, Catherine Otieno, Charles Mutinda, Victor Ochuodho, Barbra A. Richardson, Kristjana H. Asbjornsdottir, Stephen E. Hawes, James A. Berkley, Judd L. Walson
Summary: This study found that hospitalized children have higher gut permeability than children in the community, but it is not associated with post-discharge growth or systemic inflammation.
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2022)
Article
Multidisciplinary Sciences
Md Fakhar Uddin, Sassy Molyneux, Kui Muraya, Julie Jemutai, James A. Berkley, Judd L. Walson, Md Alamgir Hossain, Md Aminul Islam, Scholastica M. Zakayo, Rita Wanjuki Njeru, Tahmeed Ahmed, Mohammod Jobayer Chisti, Haribondhu Sarma
Summary: This study explored the post-discharge treatment-seeking and recovery experiences of undernourished children in Bangladesh through qualitative research methods. The findings identified drivers of treatment-seeking that support recovery and challenges faced by families and health workers. These results can inform the development of interventions to improve post-discharge adherence to medical advice and promote recovery.
Article
Nutrition & Dietetics
Adino Tesfahun Tsegaye, Patricia B. Pavlinac, Lynnth Turyagyenda, Abdoulaye H. Diallo, Blaise S. Gnoumou, Roseline M. Bamouni, Wieger P. Voskuijl, Meta van den Heuvel, Emmie Mbale, Christina L. Lancioni, Ezekiel Mupere, John Mukisa, Christopher Lwanga, Michael Atuhairwe, Mohammod J. Chisti, Tahmeed Ahmed, Abu S. M. S. B. Shahid, Ali F. Saleem, Zaubina Kazi, Benson O. Singa, Pholona Amam, Mary Masheti, James A. Berkley, Judd L. Walson, Kirkby D. Tickell
Summary: This study evaluated the contribution of household food insecurity and dietary diversity to the time to recovery from wasting in children. The findings suggest that food insecurity and dietary diversity are not major determinants of recovery, but consumption of legumes and nuts prior to diagnosis may lead to quicker recovery.
Article
Endocrinology & Metabolism
Jose Villar, Roseline Ochieng, Robert B. Gunier, Aris Papageorghiou, Stephen Rauch, Rose McGready, Julia M. Gauglitz, Fernando C. Barros, Manu Vatish, Michelle Fernandes, Victor Zammit, Verena Carrara, Shama Munim, Rachel Craik, Hellen C. Barsosio, Maria Carvalho, James A. Berkley, Leila I. Cheikh Ismail, Shane A. Norris, Chrystelle O. O. Tshivuila-Matala, Francois Nosten, Eric Ohuma, Alan Stein, Ann Lambert, Adele Winsey, Ricardo Uauy, Brenda Eskenazi, Zulfiqar A. Bhutta, Stephen Kennedy
Summary: This study aimed to investigate the relationships between maternal metabolite signatures, fetal abdominal growth, and postnatal growth, adiposity, and neurodevelopment. The study identified four distinct trajectories of fetal abdominal circumference growth and found corresponding metabolite signatures associated with these growth trajectories. The findings have implications for the early identification of infants at risk of obesity.
LANCET DIABETES & ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Alison Talbert, Moses Ngari, Christina Obiero, Amek Nyaguara, Martha Mwangome, Neema Mturi, Nelson Ouma, Mark Otiende, James Berkley
Summary: The number of young infants admitted to a county hospital in Kenya is increasing. The inpatient case fatality rate is 16% and the 1-year post-discharge mortality rate is 5.7%. Inpatient deaths are associated with disease severity, while post-discharge deaths are associated with hospitalization length, leaving against advice, and referral. This highlights the need for improved post-discharge care and services.
Article
Health Care Sciences & Services
Paraskevi Massara, Arooj Asrar, Celine Bourdon, Moses Ngari, Charles D. G. Keown-Stoneman, Jonathon L. Maguire, Catherine S. Birken, James A. Berkley, Robert H. J. Bandsma, Elena M. Comelli
Summary: This study assessed the performance of six methods for detecting different types of outliers, proposed two novel methods for outlier trajectory detection, and evaluated the impact of outliers on growth pattern detection. The results showed that model-based outlier detection methods performed best for measurements, especially for low and moderate error intensities. The clustering-based outlier trajectory method performed exceptionally well across all types and intensities of errors. Comparing growth groups with and without outliers demonstrated that outliers can alter group membership.
BMC MEDICAL RESEARCH METHODOLOGY
(2023)
Letter
Nutrition & Dietetics
Marko Kerac, Marie McGrath, James A. Berkley, Carlos S. Grijalva-Eternod, Natasha Lelijveld, Martha Mwangome, Eleanor Rogers
JOURNAL OF NUTRITIONAL SCIENCE
(2023)
Article
Nutrition & Dietetics
Susan Thurstans, Stephanie Wrottesley, Bridget Fenn, Tanya Khara, Paluku Bahwere, James A. Berkley, Robert E. Black, Erin Boyd, Michel Garenne, Sheila Isanaka, Natasha Lelijveld, Christine M. McDonald, Andrew Mertens, Martha Mwangome, Kieran S. O'Brien, Heather Stobaugh, Sunita Taneja, Keith P. West, Saul Guerrero, Marko Kerac, Andre Briend, Mark Myatt
Summary: The risk of death from undernutrition is higher in younger children than in older children. Boys have a higher prevalence of undernutrition than girls. The risk of death is higher in younger children for underweight and stunting, but not for wasting. There are no sex differences in mortality risk for all deficits.
MATERNAL AND CHILD NUTRITION
(2023)
Article
Clinical Neurology
Isaac J. Egesa, Charles R. J. C. Newton, Symon M. Kariuki
Summary: The study found that the two ILAE classification schemes are broadly consistent, but the introduction of the combined onset seizure category in ILAE-2017 significantly reduces the proportion of mutually exclusive focal and generalized seizures. The comprehensive classification of etiology categories in ILAE-2017 will facilitate appropriate treatment and improve prognosis.
