Article
Infectious Diseases
Yuran Cao, Yi Li, Beining Guo, Jing Zhang, Xiaojie Wu, Jicheng Yu, Guoying Cao, Yaxin Fan, Hailan Wu
Summary: This study evaluated the pharmacokinetics of levornidazole in healthy subjects and patients, and proposed an evidence-based sequential dosing regimen. Monte Carlo simulation was used to evaluate four dosing regimens. The simulations showed that satisfactory treatment outcomes were achieved for all four regimens when the minimum inhibitory concentration (MIC) was less than or equal to 1 mg/L.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Chemistry, Medicinal
Hongquan Zheng, Yan Xia, Shengjun Qu, Lin Fan, Jingjing Zhang, Zhixiang Ma, Yangsheng Chen, Hongwei Fan
Summary: This report describes findings from a Phase I clinical study evaluating the pharmacokinetics of frovatriptan succinate tablet in Chinese healthy subjects. The results showed that the drug had acceptable pharmacokinetic profile in Chinese subjects, with gender differences in exposure parameters consistently higher in females than in males.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Pharmacology & Pharmacy
Marloes van Hout, Pablo Forte, Thomas B. Jensen, Cristina Boschini, Tine A. Baekdal
Summary: This study aimed to compare different dosing schedules for oral semaglutide and their effects on the concentration of the drug in the body. The results showed that shorter fasting times significantly reduced the exposure of semaglutide in the body compared to the recommended overnight fasting period. Therefore, this study further supports the current prescribing information that patients should take oral semaglutide after an overnight fast.
CLINICAL PHARMACOKINETICS
(2023)
Article
Immunology
Fleur M. Keij, Stef Schouwenburg, Rene F. Kornelisse, Tim Preijers, Fatima Mir, Pieter Degraeuwe, Leo M. Stolk, Arianne van Driel, Sandra Kenter, Jacqueline van der Sluijs, Jojanneke Heidema, Paul C. P. den Butter, Irwin K. M. Reiss, Karel Allegaert, Gerdien A. Tramper-Stranders, Birgit C. P. Koch, Robert B. Flint
Summary: This study describes the metabolism of oral and intravenous amoxicillin in neonates and provides dosage recommendations for different age groups. Oral amoxicillin therapy is an effective, cost-effective, and convenient alternative treatment for neonates.
CLINICAL INFECTIOUS DISEASES
(2023)
Review
Pharmacology & Pharmacy
Jurjen S. Kingma, Desiree M. T. Burgers, Valerie M. Monpellier, Marinus J. Wiezer, Heleen J. Blusse Van Oud-Alblas, Janelle D. Vaughns, Catherine M. T. Sherwin, Catherijne A. J. Knibbe
Summary: Bariatric surgery can affect the absorption and metabolism of drugs, leading to earlier and potentially higher peak concentrations of orally administered drugs with inconsistent effects on concentrations and exposure. Prescribing liquid formulations to bariatric patients is beneficial, although the high sugar content may be a concern. While exposure to some drugs remains unchanged, the timing after surgery can impact drug absorption profiles.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Microbiology
Keith A. Rodvold, Mark H. Gotfried, Vipul Gupta, Amanda Ek, Praveen Srivastava, Angela Talley, Jon Bruss
Summary: This study evaluated the pharmacokinetics and distribution of TBP-PI-HBr in healthy adults, and found that Tebipenem can effectively distribute into the lungs, supporting further evaluation for the treatment of lower respiratory tract bacterial infections.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Microbiology
T. Nguyen, M. Oualha, C. Briand, M. Bendavid, A. Beranger, S. Benaboud, J-M Treluyer, Y. Zheng, F. Foissac, S. Winter, I Gana, S. Boujaafar, V Lopez, R. Berthaud, Z. Demir, N. Bouazza, D. Hirt
Summary: This study characterized ganciclovir pharmacokinetics in children and optimized dosing schemes for curative or preventive treatment of CMV infections. Dosing recommendations were provided based on body weight and estimated glomerular filtration rate, and individualized therapeutic drug monitoring was suggested for dose refinement.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2021)
Article
Endocrinology & Metabolism
Qi Pan, Xiaoxia Wang, Wenjia Li, Xiaofeng Chen, Yulei Zhuang, Qinghong Zhou, Yuhui Huang, Yijie Zhou, Li Lan, Zhijie Wang, Wenjia Wang, Juan Hong, Wei-Hua Hao, Yu-Tsai Yang, Lixin Guo
Summary: This study aimed to verify whether the oral insulin N11005 is used as a prandial insulin by comparing its pharmacokinetics (PK), pharmacodynamics (PD), and safety profiles with a short-acting biosynthetic human insulin (Novolin R). A total of 12 healthy Chinese male subjects were enrolled in the study, and the results showed that N11005 has similar PD characteristics to prandial insulins, with a faster onset of action and comparable duration of action to the reference insulin. The study also demonstrated the safety and tolerability of N11005.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Plant Sciences
Siva Rama Raju Kanumuri, Jessica Mamallapalli, Robyn Nelson, Christopher R. McCurdy, Carol A. Mathews, Chengguo Xing, Abhisheak Sharma
Summary: This study examined the clinical pharmacokinetics of kava in healthy volunteers, finding higher exposure after single-dosing and longer duration of exposure after multiple doses.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Chang Hee Kim, Sol Ip Kang, Dongseong Shin
Summary: This study investigated the potential interactions between telmisartan and rosuvastatin/ezetimibe, finding that coadministration led to a slight increase in systemic exposure to telmisartan and rosuvastatin, with no significant change in exposure to total ezetimibe. Further large-scale clinical studies may be needed to assess the generalizability of the clinical effects in patients with hypertension and dyslipidemia.
ADVANCES IN THERAPY
(2021)
Article
Pharmacology & Pharmacy
Sean P. Oosterholt, Oscar Della Pasqua
Summary: Raxibacumab is a fully humanized monoclonal antibody that blocks the interaction of Bacillus anthracis toxins and is approved for the treatment and prophylaxis of inhalational anthrax. Population pharmacokinetic modeling showed that weight was the only influential covariate affecting disposition parameters in healthy subjects receiving a 40 mg/kg IV dose of Raxibacumab.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Infectious Diseases
Yu Wang, Xiaofen Liu, Kun Li, Yaxin Fan, Jicheng Yu, Hailan Wu, Yi Li, Xiaojie Wu, Beining Guo, Xin Li, Jiali Hu, Jufang Wu, Guoying Cao, Jing Zhang
Summary: This study investigated the pharmacokinetics of doripenem in healthy Chinese subjects and evaluated the optimal dosage regimens. The findings showed linear pharmacokinetics of doripenem within a certain dose range and proposed optimal regimens based on different minimum inhibitory concentrations of pathogens. These results provide guidance for the appropriate use of doripenem.
Article
Veterinary Sciences
Carl Ekstrand, Peter Michanek, Matilda Salomonsson, Cecilia Tegner, Lena Pelander
Summary: This study aimed to investigate the plasma concentration-time course and potential adverse effects of nitrofurantoin in dogs. The results showed that nitrofurantoin had high concentrations in the plasma and urine of dogs with a short half-life. No adverse effects were observed clinically or in laboratory tests. The study suggests that nitrofurantoin could be effective in treating bacterial cystitis in dogs, but further clinical studies are needed to confirm its effectiveness.
RESEARCH IN VETERINARY SCIENCE
(2022)
Article
Pharmacology & Pharmacy
Ali Haghiri, David J. Price, Phoebe Fitzpatrick, Saber Dini, Megha Rajasekhar, Caterina Fanello, Joel Tarning, James Watson, Nicholas J. White, Julie A. Simpson
Summary: The majority of deaths from malaria occur in young African children, so it is important to determine the appropriate dosage of medication for them. The US FDA has challenged the World Health Organization's recommendation of a lower dose for younger children, but a study showed that younger children given the lower dose did not reach the same drug exposures as older children. Therefore, it is suggested to withdraw the FDA's recent lower dose recommendation.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Fanxi Guo, Dongying Liu, Yuqing Zhou, Yuanqian Yu, Yidan Xu, Yuanpeng Zou, Chongyang Li, Fengyichi Zhang, Zugong Yu
Summary: This study investigated the pharmacokinetics of orally administered glutamine tablets in Beagles. The results showed a linear relationship between dosage and certain pharmacokinetic parameters. Glutamine tablets were quickly absorbed and did not accumulate in Beagles after long-term administration.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Denise Morris, Joseph Podolski, Alan Kirsch, Ronald Wiehle, Lawrence Fleckenstein
Article
Public, Environmental & Occupational Health
Carrie A. Morris, Luis Lopez-Lazaro, Donald Jung, Janthima Methaneethorn, Stephan Duparc, Isabelle Borghini-Fuhrer, Rolf Pokorny, Chang-Sik Shin, Lawrence Fleckenstein
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2012)
Article
Public, Environmental & Occupational Health
Joan M. Korth-Bradley, Virginia Parks, Stephan Chalon, Ian Gourley, Kyle Matschke, Karine Cailleux, Serge Fitoussi, Lawrence Fleckenstein
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
(2012)
Article
Microbiology
Joan M. Korth-Bradley, Virginia Parks, Stephan Chalon, Ian Gourley, Kyle Matschke, Sophie Gossart, Philip Bryson, Lawrence Fleckenstein
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2011)
Article
Microbiology
Carrie A. Morris, Beesan Tan, Stephan Duparc, Isabelle Borghini-Fuhrer, Donald Jung, Chang-Sik Shin, Lawrence Fleckenstein
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2013)
Article
Medicine, General & Internal
Antoinette K. Tshefu, Oumar Gaye, Kassoum Kayentao, Ricardo Thompson, Kirana M. Bhatt, Sanie S. S. Sesay, Dorina G. Bustos, Emiliana Tjitra, George Bedu-Addo, Isabelle Borghini-Fuhrer, Stephan Duparc, Chang Sik Shin, Lawrence Fleckenstein
Review
Infectious Diseases
Carrie A. Morris, Stephan Duparc, Isabelle Borghini-Fuhrer, Donald Jung, Chang-Sik Shin, Lawrence Fleckenstein
Article
Infectious Diseases
Carrie A. Morris, Marie A. Onyamboko, Edmund Capparelli, Matthew A. Koch, Joseph Atibu, Vicky Lokomba, Macaya Douoguih, Jennifer Hemingway-Foday, David Wesche, Robert W. Ryder, Carl Bose, Linda Wright, Antoinette K. Tshefu, Steven Meshnick, Lawrence Fleckenstein
Article
Infectious Diseases
Marie A. Onyamboko, Steven R. Meshnick, Lawrence Fleckenstein, Matthew A. Koch, Joseph Atibu, Victor Lokomba, Macaya Douoguih, Jennifer Hemingway-Foday, David Wesche, Robert W. Ryder, Carl Bose, Linda L. Wright, Antoinette K. Tshefu, Edmund V. Capparelli
Article
Infectious Diseases
Stephan Duparc, Isabelle Borghini-Fuhrer, J. Carl Craft, Sarah Arbe-Barnes, Robert M. Miller, Chang-Sik Shin, Lawrence Fleckenstein
Article
Medicine, General & Internal
Ronnatrai Rueangweerayut, Aung Pyae Phyo, Chirapong Uthaisin, Yi Poravuth, Tran Quang Binh, Halidou Tinto, Louis K. Penali, Neena Valecha, Nong Thi Tien, Salim Abdulla, Isabelle Borghini-Fuhrer, Stephan Duparc, Chang-Sik Shin, Lawrence Fleckenstein
NEW ENGLAND JOURNAL OF MEDICINE
(2012)
Article
Multidisciplinary Sciences
Yi Poravuth, Duong Socheat, Ronnatrai Rueangweerayut, Chirapong Uthaisin, Aung Pyae Phyo, Neena Valecha, B. H. Krishnamoorthy Rao, Emiliana Tjitra, Asep Purnama, Isabelle Borghini-Fuhrer, Stephan Duparc, Chang-Sik Shin, Lawrence Fleckenstein
Article
Infectious Diseases
Jonathan D. Grein, Glenn E. Mathisen, Suzanne Donovan, Lawrence Fleckenstein
SCANDINAVIAN JOURNAL OF INFECTIOUS DISEASES
(2010)
Article
Pharmacology & Pharmacy
Joan M. Korth-Bradley, Virginia Parks, Alain Patat, Kyle Matschke, Philip Mayer, Lawrence Fleckenstein
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT
(2012)
Article
Oncology
Gerard R. Rutteman, Suzanne A. Erich, Jan A. Mol, Bart Spee, Guy C. M. Grinwis, Lawrence Fleckenstein, Cheryl A. London, Thomas Efferth
ANTICANCER RESEARCH
(2013)