Journal
MALARIA JOURNAL
Volume 7, Issue -, Pages -Publisher
BMC
DOI: 10.1186/1475-2875-7-9
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Funding
- Wellcome Trust Funding Source: Medline
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Slowly eliminated antimalarial drugs suppress malaria reinfections for a period of time determined by the dose, the pharmacokinetic properties of the drug, and the susceptibility of the infecting parasites. This effect is called post-treatment prophylaxis ( PTP). The clinical benefits of preventing recrudescence ( reflecting treatment efficacy) compared with preventing reinfection ( reflecting PTP) need further assessment. Antimalarial drug resistance shortens PTP. While blood concentrations are in the terminal elimination phase, the degree of shortening may be estimated from measurements of in-vitro susceptibility and the terminal elimination half-life. More information is needed on PTP following intermittent preventive treatments, and on the relationship between the duration of PTP and immunity, so that policy recommendations can have a firmer evidence base.
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