Article
Multidisciplinary Sciences
Ro Woon Lee, Yeo Ju Kim, Daehyun Yoon, Seunghun Lee, Jeongah Ryu
Summary: MAVRIC SL T2 technique reduces metallic artifacts in the postoperative cervical spine with ADR and is more clinically useful than T2WI in evaluating the spinal cord and nerve roots.
SCIENTIFIC REPORTS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyungseok Jang, Yajun Ma, Michael Carl, Saeed Jerban, Eric Y. Chang, Jiang Du
Summary: This study aimed to develop a new technique, UTE-Cones-DESS, for efficient imaging of musculoskeletal tissues with short T2s, as well as proposing a novel fat suppression method using spDixon. Results showed that UTE-Cones-DESS sequence allows fast volumetric imaging with high contrast for musculoskeletal tissues, while spDixon achieves efficient fat suppression in the images.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vadim Malis, Yoshimori Kassai, Diana Vucevic, Won C. Bae, Yoshiharu Ohno, Andrew Yen, Mitsue Miyazaki
Summary: The purpose of this study was to develop 3D ultrashort-TE (UTE) sequences with tight TE intervals to accurately map T2* values of lungs during free breathing. A Monte-Carlo simulation was used to optimize the number of echoes and a validation study was conducted on a known T2* phantom. The sequence was successfully applied to human lung imaging and provided valuable insights into diseased lungs.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Pediatrics
Daniel Grafe, Rebecca Anders, Freerk Prenzel, Ina Sorge, Christian Roth, Thomas Benkert, Franz Wolfgang Hirsch
Summary: This study compared the diagnostic value of a respiratory-self-gated three-dimensional UTE sequence with a conventional respiratory-triggered T2-weighted turbo spin echo (T2-TSE) sequence in pediatric patients. The image quality of both sequences was high, with UTE showing clearer visualization of pleural and central bronchi. UTE was superior to T2-TSE for certain pathologies like air trapping and showed equivalent performance in other pathologies.
PEDIATRIC PULMONOLOGY
(2021)
Review
Engineering, Biomedical
Luis Fernando Velasquez-Garcia, Yosef Kornbluth
Summary: Additive manufacturing is suitable for a wide range of biomedical applications due to its customization, low cost, seamless interface with medical imaging techniques, and ability to create free-form objects in biocompatible and biodegradable materials.
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 23, 2021
(2021)
Article
Orthopedics
Li-Lan Wu, Li-Heng Liu, Sheng-Xiang Rao, Pu-Yeh Wu, Jian-Jun Zhou
Summary: This study compared the potential of ultrashort time-to-echo (UTE) T2* mapping and T2* values for assessing lumbar intervertebral disc degeneration (IVDD). The results showed that UTE-T2* relaxometry was more accurate than T2* mapping in detecting early stage IVDD.
BMC MUSCULOSKELETAL DISORDERS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Muhammad A. R. Anjum, Felix M. Gonzalez, Anshuman Swain, Johannes Leisen, Zahra Hosseini, Adam Singer, Monica Umpierrez, David A. Reiter
Summary: The study demonstrates the use of multi-component relaxation modeling for quantitative analysis of human Achilles tendon, showing that the multi-component model provides a higher quality of fit with slightly increased estimate variance compared to the bi-component model. Bi-component estimates exhibit notable bias, particularly in the presence of off-resonance components.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Orthopedics
Sara E. Sacher, John P. Neri, Madeleine A. Gao, Erin C. Argentieri, Hollis G. Potter, Kevin M. Koch, Matthew F. Koff
Summary: This study used MAVRIC-based T2 Mapping technique to measure the T2 values of IPFP in TKA patients and found that these values are related to fat pad scarring and clinical MRI findings. T2 values were elevated in patients with severe scarring and osteolysis. This suggests that MAVRIC-based T2 Mapping can be used as a quantitative biomarker of postoperative IPFP scarring in TKA individuals.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Chemistry, Analytical
Jiyo S. Athertya, Yajun Ma, Amir Masoud Afsahi, Alecio F. Lombardi, Dina Moazamian, Saeed Jerban, Sam Sedaghat, Hyungseok Jang
Summary: In this study, the feasibility of accelerated quantitative Ultrashort Echo Time Cones imaging with compressed sensing reconstruction was investigated. The results showed that compressed sensing reconstruction dramatically reduced artifacts and improved image quality, making it a promising technique for fast clinical scans.
Article
Oncology
Felipe Sanchez, Pascal N. Tyrrell, Patrick Cheung, Chinthaka Heyn, Simon Graham, Ian Poon, Yee Ung, Alexander Louie, May Tsao, Anastasia Oikonomou
Summary: This study aimed to explore the performance of lung MRI in detecting solid and subsolid pulmonary nodules using T1 gradient-echo (GRE), ultrashort time echo (UTE), and T2 Fast Spin Echo (HASTE). The results showed that lung MRI has adequate performance in detecting solid and subsolid pulmonary nodules larger than 4 mm and can serve as a promising radiation-free alternative to CT.
Article
Medicine, Research & Experimental
Masaki Hirano, Yuki Muto, Masahiro Kuroda, Yuta Fujiwara, Tomoaki Sasaki, Kazuhiro Kuroda, Ryo Kamizaki, Satoshi Imajoh, Yoshinori Tanabe, Wlla E. Al-Hammad, Yuki Nakamitsu, Yudai Shimizu, Kohei Sugimoto, Masataka Oita, Irfan Sugianto, Babatunde O. Bamgbose
Summary: Magnetic resonance imaging (MRI) is superior to computed tomography (CT) in determining changes in tissue structure. However, MRI exhibits more distortion and artifacts when metal implants or objects are present. The present study aimed to evaluate whether the novel MRI sequence, multiacquisition variable-resonance image combination selective (MAVRIC SL), could accurately measure metal implants without distortion and artifacts. The results showed that MAVRIC SL outperformed other sequences in terms of distortion, lack of bias, and reduced artifact regions, suggesting its potential for follow-up observations of metal implant insertions.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kushaljit Singh Sodhi, Anmol Bhatia, Pratyaksha Rana, Joseph L. Mathew
Summary: This study assessed the impact of radial percentage k-space filling and signal averaging on lung MRI image quality in 3D radial ultrashort echo-time (UTE) acquisition. The results showed that the R100_NSA2 UTE sequence performed best for the evaluation of different findings and showed the best image quality.
ACADEMIC RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Lena Marie Wilms, Karl Ludger Radke, David Latz, Thomas Andreas Thiel, Miriam Frenken, Benedikt Kamp, Timm Joachim Filler, Armin Michael Nagel, Anja Mueller-Lutz, Daniel Benjamin Abrar, Sven Nebelung
Summary: This study evaluates the potential of MRI sequences in the diagnosis of PCL injuries. The results show that UTE-T2* mapping is more suitable for detecting structural damage of the PCL and allows quantitative assessment of ligament structure and integrity, which can improve the diagnostic differentiation of different injury states.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Review
Orthopedics
Meng Meng, Jinzuo Wang, Huagui Huang, Xin Liu, Jing Zhang, Zhonghai Li
Summary: This paper systematically reviews the literature on 3D printing orthopedic metal implants over the past decade. It introduces the advantages and applications of 3D printing technology and discusses its potential possibilities in orthopedic surgery. The paper emphasizes the personalized nature of 3D printing technology and its advantages in improving patient recovery.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Mathematical & Computational Biology
Qing Zou, Zachary Miller, Sanja Dzelebdzic, Maher Abadeer, Kevin M. Johnson, Tarique Hussain
Summary: This study proposes a novel time-resolved 3D cardiopulmonary MRI reconstruction method based on spatial transformer networks (STNs) to reconstruct the 3D cardiopulmonary MRI acquired using 3D center-out radial ultra-short echo time (UTE) sequences. The results showed that the proposed time-resolved 3D cardiopulmonary MRI reconstruction using STNs offers a robust and efficient approach to obtain high-quality images and has the potential to improve the diagnosis and treatment planning of cardiopulmonary disorders.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yan-Ping Xue, Ya-Jun Ma, Mei Wu, Saeed Jerban, Zhao Wei, Eric Y. Chang, Jiang Du
Summary: This study demonstrates the potential clinical use of MMF in early detection of OA, as MMF showed significant negative correlations with KL grade and WORMS, lower MMFs were found in subjects with more severe KL grade and in cartilage with greater extent and depth of lesions, and AUC values of MMF for doubtful-minimal OA and mild cartilage degradation were 0.8 and 0.7, respectively.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hyungseok Jang, Yajun Ma, Michael Carl, Saeed Jerban, Eric Y. Chang, Jiang Du
Summary: This study aimed to develop a new technique, UTE-Cones-DESS, for efficient imaging of musculoskeletal tissues with short T2s, as well as proposing a novel fat suppression method using spDixon. Results showed that UTE-Cones-DESS sequence allows fast volumetric imaging with high contrast for musculoskeletal tissues, while spDixon achieves efficient fat suppression in the images.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alecio F. Lombardi, Jonathan H. Wong, Rachel High, Yajun Ma, Saeed Jerban, Qingbo Tang, Jiang Du, Patrick Frost, Mark D. Pagel, Eric Y. Chang
Summary: This study demonstrated that acidoCEST MRI can measure the extracellular pH of bone marrow affected by multiple myeloma, showing strong correlations with the metabolic phenotype of BM tumor assessed by immunofluorescent histological assessment of GLUT1 overexpression in an MM orthotopic mouse model.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Amir Masoud Afsahi, Yajun Ma, Hyungseok Jang, Saeed Jerban, Christine B. Chung, Eric Y. Chang, Jiang Du
Summary: This review article summarizes recent technical developments in ultrashort echo time (UTE) magnetic resonance imaging of musculoskeletal (MSK) tissues with short-T2 relaxation times. It discusses contrast mechanisms for high-contrast morphological imaging of short-T2 MSK tissues and introduces quantitative UTE mapping techniques.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Orthopedics
Saeed Jerban, Takehito Hananouchi, Yajun Ma, Behnam Namiranian, Erik W. Dorthe, Jonathan H. Wong, Niloofar Shojaeiadib, Mei Wu, Jiang Du, Darryl D'Lima, Christine B. Chung, Eric Y. Chang
Summary: The study investigated the correlations between the mechanical and microstructural properties of human ACL specimens and quantitative three-dimensional UTE Cones MRI measures. The results showed significant moderate correlations between UTE-MRI biomarkers and the elastic modulus of ACL, but nonsignificant correlations with histomorphometry measures.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Biophysics
Lidi Wan, Xin Cheng, Adam C. Searleman, Ya-Jun Ma, Jonathan H. Wong, R. Scott Meyer, Jiang Du, Guangyu Tang, Eric Y. Chang
Summary: The study aimed to investigate the feasibility of quantitative 3D ultrashort echo time (UTE)-based biomarkers in detecting proteoglycan (PG) loss and collagen degradation in human cartilage. The results showed that AdiabT(1 rho) and T-1 have the potential for detecting PG loss, while MMF and MTR are promising for the detection of collagen degradation in articular cartilage, facilitating earlier, noninvasive diagnosis of osteoarthritis.
NMR IN BIOMEDICINE
(2022)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Hyungseok Jang, Jiang Du
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhao Wei, Alecio F. Lombardi, Roland R. Lee, Mark Wallace, Koichi Masuda, Eric Y. Chang, Jiang Du, Graeme M. Bydder, Wenhui Yang, Ya-Jun Ma
Summary: This study used ultrashort echo time (UTE) scanning technique to evaluate intervertebral discs and found that T-1 rho values are associated with the degree of disc degeneration and age. In addition, there are differences in T-1 rho values between subjects with and without low back pain.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Alecio F. Lombardi, Yajun Ma, Hyungseok Jang, Saeed Jerban, Qingbo Tang, Adam C. Searleman, Robert Scott Meyer, Jiang Du, Eric Y. Chang
Summary: This study compared the pH measured in knee joints of individuals without osteoarthritis (OA) and patients with severe OA using acidoCEST-UTE MRI. The results showed that patients with OA had lower pH values in their cartilage, meniscus, and fluid compared to individuals without OA. Moreover, lower pH measurements were associated with worse symptoms and knee-joint function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Saeed Jerban, Salem Alenezi, Amir Masoud Afsahi, Yajun Ma, Jiang Du, Christine B. B. Chung, Eric Y. Y. Chang
Summary: This review article describes the potential of using MRI-based micro-FEA as a non-invasive method to predict bone mechanical competence and assess fracture risk, and discusses its applications and future potential.
MAGNETIC RESONANCE IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hongda Shao, Jiawei Yang, Yajun Ma, Xiaolian Su, Guangyu Tang, Junjie Jiang, Jiang Du, Jianjun Liu
Summary: The study aimed to investigate the diagnostic efficacy of multi-parametric quantitative UTE-based MRI for evaluating human cartilage degeneration. Among the quantitative MRI biomarkers, UTE-MTR had the strongest correlation with OA grade and collagen organization score. UTE-MTR showed the highest diagnostic efficacy for mild cartilage degeneration, while UTE-AdiabT1 rho and CubeQuant-T2 had lower efficacy.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Medicine, General & Internal
Saeed Jerban, Yajun Ma, Amir Masoud Afsahi, Alecio Lombardi, Zhao Wei, Meghan Shen, Mei Wu, Nicole Le, Douglas G. Chang, Christine B. Chung, Jiang Du, Eric Y. Chang
Summary: This study utilized UTE-MT modeling and MRI techniques to detect the correlation between tendon quality deterioration in osteoporosis patients and bone health, highlighting the importance of UTE-MT MRI techniques in evaluating tendon quality.
Review
Radiology, Nuclear Medicine & Medical Imaging
Ya-Jun Ma, Dina Moazamian, Daniel M. Cornfeld, Paul Condron, Samantha J. Holdsworth, Mark Bydder, Jiang Du, Graeme M. Bydder
Summary: This paper updates and extends previous studies on TP-filters, MASTIR pulse sequences, and scMRI by introducing the central contrast theorem and division. These concepts are used to improve tissue boundaries contrast, detect small changes in the brain, and quantify T1. The paper also explains the basis for high contrast boundaries and provides examples.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mei Wu, Ya-Jun Ma, Mouyuan Liu, Yanping Xue, Lillian Gong, Zhao Wei, Saeed Jerban, Hyungseok Jang, Douglas G. Chang, Eric Y. Chang, Liheng Ma, Jiang Du
Summary: The study evaluated the quantitative assessment of articular cartilage degeneration using 3D UTE-Cones-AdiabT(1 rho) imaging technique. Significant differences in UTE-Cones-AdiabT(1 rho) values were observed among different extents and depths of cartilage lesions, indicating its potential for early diagnosis of cartilage degeneration.
EUROPEAN RADIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Takehito Hananouchi, Tomoyuki Suzuki, Erik W. Dorthe, Jiang Du, Darryl D. D'Lima
Summary: Using a probing device, the resistance force of dissected ACLs was measured, and its correlation with the mechanical properties of the ligaments was investigated. The results showed a moderate correlation, suggesting that the tension of the reconstructed ACL after fixation can be derived from the value of the probing device.
BIOENGINEERING-BASEL
(2022)
