Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 69, Issue 2, Pages 538-544Publisher
WILEY
DOI: 10.1002/mrm.24281
Keywords
P-31 imaging; quantitative MRI; twisted projection imaging; ultra-high field; flexTPI; PCr; ATP ratio
Funding
- PHS [RO1 NS386760, RO1 CA129553]
- Chicago Biomedical Consortium (SPARK Award)
- Chicago Community Trust (Searle Funds)
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Quantitative 31P magnetic resonance imaging of the whole human brain is often time-consuming even at low spatial resolution due to the low concentrations, long T1 relaxation times, and low detection sensitivity of phosphorus metabolites. We report herein the results of combining the increased detection sensitivity of an ultra-high field 9.4 T scanner designed for human imaging with a new pulse sequence termed simultaneously imaging of multiple spectral peaks with interleaved excitations and flexible twisted projection imaging readout trajectories to rapidly sample multiple resonances in the 31P spectrum. The phosphocreatine and ?-adenosine triphosphate images, obtained simultaneously from the entire human head, are demonstrated at 1.5 cm isotropic nominal resolution in a total acquisition time of 33 min. The phosphocreatine/?-adenosine triphosphate ratio calculated for brain parenchyma (12) and the superficial temporalis muscle (35) are in agreement with literature values. Magn Reson Med, 2013. (C) 2012 Wiley Periodicals, Inc.
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