Article
Oncology
Yurie Seto, Yoshiko Kaneko, Takako Mouri, Daisuke Shimizu, Yoshie Morimoto, Shinsaku Tokuda, Masahiro Iwasaku, Tadaaki Yamada, Koichi Takayama
Summary: In this study, the ratio of TGF-I3 levels before and after 30-48 Gy irradiation may predict the onset of RILI in patients undergoing radiation therapy for locally advanced lung cancer. These findings could help identify predictors of radiation-induced lung injury.
TRANSLATIONAL LUNG CANCER RESEARCH
(2022)
Article
Immunology
Janna Berg, Ann Rita Halvorsen, May-Bente Bengtson, Morten Lindberg, Bente Halvorsen, Pal Aukrust, Aslaug Helland, Thor Ueland
Summary: This study found that T cell activation and exhaustion markers sCD25 and sTIM-3 are enhanced in NSCLC patients developing radiation pneumonitis (RP) and are associated with poor survival.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Matthew R. McFarlane, Kimberly A. Hochstedler, Anna M. Laucis, Yilun Sun, Aulina Chowdhury, Martha M. Matuszak, James Hayman, Derek Bergsma, Thomas Boike, Larry Kestin, Benjamin Movsas, Inga Grills, Michael Dominello, Robert T. Dess, Caitlin Schonewolf, Daniel E. Spratt, Lori Pierce, Peter Paximadis, Shruti Jolly, Matthew Schipper
Summary: This study analyzed pneumonitis risk after radiation therapy for lung cancer using a large, prospective dataset. Comorbidity burden, smoking status, and dosimetric parameters were incorporated in an integrated risk model to guide clinicians in assessing pneumonitis risk in individual patients.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Yan Li, Daniel B. Vigneron, Duan Xu
Summary: Hyperpolarized carbon-13 MR metabolic imaging is crucial for acquiring real-time dynamic metabolic information and gaining insights into metabolic pathways, but faces significant challenges in broader clinical translation despite rapid development.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Medicine, General & Internal
Sara Torresan, Gaia Zussino, Francesco Cortiula, Alessandro Follador, Gianpiero Fasola, Rossano Girometti, Lorenzo Cereser
Summary: We report a case of radiation recall pneumonitis followed by immune-checkpoint inhibitor-induced pneumonitis in a patient with non-small cell lung cancer. This case emphasizes the importance of considering radiation recall pneumonitis in the differential diagnosis of lung consolidation during immunotherapy and suggests that it may anticipate more extensive immune-checkpoint inhibitor-induced pneumonitis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Xiaotong Lu, Jianyang Wang, Tao Zhang, Zongmei Zhou, Lei Deng, Xin Wang, Wenqing Wang, Wenyang Liu, Wei Tang, Zhijie Wang, Jie Wang, Wei Jiang, Nan Bi, Luhua Wang
Summary: This retrospective study investigated the risk of treatment-related pneumonitis in Chinese lung cancer patients who received thoracic radiotherapy (TRT) followed by immune checkpoint inhibitor (ICI) therapy. The results showed that the occurrence of pneumonitis was relatively high, but manageable, and dosimetric parameters could improve the prediction of radiation recall pneumonitis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Francois Cousin, Colin Desir, Selma Ben Mustapha, Carole Mievis, Philippe Coucke, Roland Hustinx
Summary: This study found a high incidence of radiation recall pneumonitis (RRP) at 18.8% among patients with advanced lung cancer treated with immune checkpoint inhibitors. No risk factors for RRP were identified, but an association between RRP and ICI-related pneumonitis was noted.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Oncology
Emmanuel Mesny, Myriam Ayadi, Pauline Dupuis, Guillaume Beldjoudi, Ronan Tanguy, Isabelle Martel-Lafay
Summary: This study aimed to report the clinical outcomes and toxicities of patients treated with dynamic conformal arc therapy for primary or metastatic lung tumors. The results showed that this new technique provides efficient results of local control and low lung toxicities, similar to other techniques.
RADIATION ONCOLOGY
(2023)
Review
Oncology
Yujie Yan, Jiamei Fu, Roman O. Kowalchuk, Christopher M. Wright, Ran Zhang, Xuefei Li, Yaping Xu
Summary: This narrative review provides a comprehensive description and summary of radiation-induced lung injury (RILI), from its biological mechanisms to clinical management. The underlying causes of RILI are multifactorial, involving gene-level changes, signaling pathways, cell interactions, and the expression of cytokines and chemokines. Based on these mechanisms, various novel treatment strategies have been proposed and applied in clinical practice.
TRANSLATIONAL LUNG CANCER RESEARCH
(2022)
Article
Plant Sciences
Savita Verma, Ajaswrata Dutta, Akshu Dahiya, Namita Kalra
Summary: The study found that Quercetin-3-Rutinoside (Q-3-R) can protect against radiation-induced lung injury by regulating NF-Kappa B/TGF-beta 1 signaling pathway, scavenging free radicals, preventing perivascular infiltration, and prolonged inflammatory cascade. This may have potential therapeutic effects on lung damage caused by planned or unplanned radiation exposure.
Article
Oncology
Anqi Zhang, Fuyuan Yang, Lei Gao, Xiaoyan Shi, Jiyuan Yang
Summary: Radiation pneumonitis is a common and serious complication of thoracic radiotherapy, and the use of immune checkpoint inhibitors in the treatment of non-small cell lung cancer may increase the risk of immune-related adverse events. This paper reviews the occurrence of radiation pneumonitis, immune pneumonitis, and combined treatment and provides the latest research results.
CANCER MANAGEMENT AND RESEARCH
(2022)
Article
Oncology
Bing Li, Xiaoli Zheng, Jiang Zhang, Saikit Lam, Wei Guo, Yunhan Wang, Sunan Cui, Xinzhi Teng, Yuanpeng Zhang, Zongrui Ma, Ta Zhou, Zhaoyang Lou, Lingguang Meng, Hong Ge, Jing Cai
Summary: The study evaluates the effectiveness of features obtained from proposed incremental-dose-interval-based lung subregion segmentation for predicting grade >= 2 acute radiation pneumonitis (ARP) in lung cancer patients. Results show that features from lung subregions outperform those from the whole lung in predicting ARP, especially when using dosiomics or combined radiomics-dosiomics features. This improved model performance could enhance clinical management and patient quality of life.
Article
Health Care Sciences & Services
Marek Konkol, Maciej Bryl, Marek Fechner, Krzysztof Matuszewski, Pawel Sniatala, Piotr Milecki
Summary: Radiation-induced lung injury is a significant toxicity in thoracic radiotherapy. This study aimed to establish a quantitative grading method by analyzing the changes in lung tissue density using CT scans. The results confirmed a dose-response effect and identified clinical factors that correlated with the degree of lung injury.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Multidisciplinary Sciences
Kuan-Heng Lin, Chen-Xiong Hsu, Shan-Ying Wang, Greta S. P. Mok, Chiu-Han Chang, Hui-Ju Tien, Pei-Wei Shueng, Tung-Hsin Wu
Summary: This study developed a volume-based algorithm (VBA) to predict lung V-5 and optimize lung dose in treatment planning. The predicted lung V-5 was positively correlated with actual lung V-5, while a decrease in arc angle led to a decrease in lung dose and an increase in heart dose.
SCIENTIFIC REPORTS
(2021)
Article
Transplantation
Elena Qirjazi, Fabio R. Salerno, Alireza Akbari, Lisa Hur, Jarrin Penny, Timothy Scholl, Christopher W. McIntyre
Summary: This study utilized Na-23 MRI to measure tissue sodium concentrations in CKD, HD, and PD patients, finding higher sodium concentrations in the skin, soleus, and tibia of HD and PD patients compared to controls. Correlations were also observed between certain blood-based biomarkers and tissue sodium concentrations in HD patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qi Qi, Matthew S. Fox, Heeseung Lim, Robert Bartha, Timothy J. Scholl, Lisa Hoffman, Ting-Yim Lee, Jonathan D. Thiessen
Summary: This study found that glucoCEST is more strongly correlated with measurements of perfusion than glycolysis. However, glucoCEST measurements have additional confounds, such as sensitivity to changing pH, that merit further investigation.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Review
Oncology
Vasudeva Bhat, Sierra Pellizzari, Alison L. Allan, Eugene Wong, Michael Lock, Muriel Brackstone, Ana Elisa Lohmann, David W. Cescon, Armen Parsyan
Summary: Radiation therapy has local control effects in advanced or metastatic breast cancer, but radioresistance is a challenge. Combining radiation therapy with radiosensitizers has the potential to improve treatment outcomes.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Nourhan Shalaby, John Kelly, Francisco Martinez, Mathew Fox, Qi Qi, Jonathan Thiessen, Justin Hicks, Timothy J. Scholl, John A. Ronald
Summary: The study developed a dual MRI/PET reporter gene system for noninvasive tracking of engineered cells, combining the high resolution of MRI and sensitivity of PET, offering a new approach to cell tracking and potentially broader applications within the healthcare system in the future.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alireza Akbari, Sandrine Lemoine, Fabio Salerno, Taylor L. Marcus, Tristan Duffy, Timothy J. Scholl, Guido Filler, Andrew A. House, Christopher W. McIntyre
Summary: This study investigated the ability of sodium MRI to measure corticomedullary gradient (CMG) dynamics and compared it with urinary osmolarity. The results showed that functional sodium MRI accurately depicted CMG changes and demonstrated the feasibility of CMG measurement in both healthy volunteers and participants with reduced kidney function.
Article
Urology & Nephrology
Fabio R. Salerno, Alireza Akbari, Sandrine Lemoine, Guido Filler, Timothy J. Scholl, Christopher W. McIntyre
Summary: This study found that higher skin sodium concentration is associated with worse clinical outcomes in dialysis patients and may serve as a direct therapeutic target. Dialysate sodium concentration, serum albumin, and congestive heart failure were significantly associated with skin sodium concentration.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Pediatrics
Fabio R. Salerno, Alireza Akbari, Sandrine Lemoine, Timothy J. Scholl, Christopher W. McIntyre, Guido Filler
Summary: Pediatric CKD is associated with altered tissue sodium concentration compared to healthy controls, with increased sodium concentration in glomerular disease and reduced sodium concentration in tubular disorders.
PEDIATRIC NEPHROLOGY
(2023)
Article
Oncology
Nivin N. Nystrom, Sean W. McRae, Francisco M. Martinez, John J. Kelly, Timothy J. Scholl, John A. Ronald
Summary: Metastasis is the main cause of cancer-related death, but it is not well understood, and most cancer studies only focus on the primary tumor. The lack of tools for accurate measurement of metastatic spread in vivo contributes to this gap. In this study, oatp1b3-MRI was developed as an imaging reporter system for sensitive detection of cancer cells, allowing tracking of metastases at high resolution and sensitivity. The system was able to detect micrometastases in deep tissues with a high number of cancer cells. This reporter gene system provides a useful tool for studying metastasis.
Article
Chemistry, Medicinal
Sean W. McRae, Michael Cleary, Daniel DeRoche, Francisco M. Martinez, Ying Xia, Peter Caravan, Eric M. Gale, John A. Ronald, Timothy J. Scholl
Summary: In this study, five amphiphilic, anionic Mn(II) complexes were synthesized as contrast agents targeted to organic anion transporting polypeptide transporters (OATP) for liver magnetic resonance imaging (MRI). These complexes were synthesized in three steps from the commercially available trans-1,2-diaminocyclohexane-N,N,N',N'-tetraacetic acid (CDTA) chelator, with T1-relaxivity ranging between 2.3 and 3.0 mM-1 s-1 at 3.0 T. The pharmacokinetics and uptake of these complexes in OATPs were assessed in vivo and in vitro, demonstrating their potential as OATP-targeted contrast agents.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Engineering, Biomedical
Erin Iredale, Abdulla Elsaleh, Hu Xu, Paul Christiaans, Andrew Deweyert, John Ronald, Susanne Schmid, Matthew O. Hebb, Terry M. Peters, Eugene Wong
Summary: This study investigated the feasibility of using low intensity electric fields to treat glioblastoma (GBM). Computer simulations and in vitro experiments were conducted to evaluate the effects of spatiotemporally dynamic electric fields on GBM cell viability. The results showed that rotating electric fields significantly reduced cell viability, and the strength and homogeneity of the electric field were important factors in determining the treatment efficacy.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Multidisciplinary Sciences
TianDuo Wang, Yuanxin Chen, Nivin N. Nystrom, Shirley Liu, Yanghao Fu, Francisco M. Martinez, Timothy J. Scholl, John A. Ronald
Summary: Cell-cell communication is crucial in multicellular organisms, especially in cell-based cancer immunotherapies where engineered immune cells interact with cancer cells through specific antigens. By using the synthetic Notch system, T cells engineered in this study were able to induce the expression of reporter genes in response to interaction with a chosen antigen on neighboring cancer cells. The high spatial resolution and tomographic nature of MRI allowed for clear visualization and mapping of the engineered cells within tumors, showing promise for monitoring cell therapies in patients and understanding interactions between cell populations in the body.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Maryam Mozaffari, Nivin N. N. Nystrom, Alex Li, Miranda Bellyou, Timothy J. J. Scholl, Robert Bartha
Summary: Pharmacologically induced acidification of cancerous tissue can be detected and monitored using magnetic resonance imaging. In this study, the sodium proton exchanger inhibitor Cariporide was tested to determine its effectiveness in acidifying C6 glioma tumors in rats with intact immune systems. CEST MRI was used to measure tissue intracellular pH, and the results showed that Cariporide significantly increased acidity in the tumors compared to pre-injection levels. This study highlights the sensitivity of CEST-based pH-weighted imaging in monitoring the response of tumors to pharmacologically induced acidification.
Article
Radiology, Nuclear Medicine & Medical Imaging
Heeseung Lim, Francisco Martinez-Santiesteban, Michael D. Jensen, Albert Chen, Eugene Wong, Timothy J. Scholl
Article
Oncology
Nivin N. Nystrom, Lawrence C. M. Yip, Jeffrey J. L. Carson, Timothy J. Scholl, John A. Ronald
RADIOLOGY-IMAGING CANCER
(2019)
Article
Neurosciences
Richard A. Harris, Asad Lone, Heeseung Lim, Francisco Martinez, Ariel K. Frame, Timothy J. Scholl, Robert C. Cumming