Article
Computer Science, Artificial Intelligence
Gabriel Della Maggiora, Carlos Castillo-Passi, Wenqi Qiu, Shuang Liu, Carlos Milovic, Masaki Sekino, Cristian Tejos, Sergio Uribe, Pablo Irarrazaval
Summary: In this study, a new Deep Learning method was proposed to quantify the distribution of SPIO concentration. The method utilized a novel data acquisition sequence and multiple decoders to improve gradient flow. The accuracy of the method was demonstrated through tests with simulated images and actual scan data.
IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE
(2022)
Article
Biochemical Research Methods
Jiaqian Li, Steven E. Kirberger, Yiao Wang, Huarui Cui, Carston R. Wagner, William C. K. Pomerantz
Summary: The design of imaging agents with high fluorine content is important for overcoming signal detection limits in F-19 MRI-based molecular imaging. This study characterizes new highly fluorinated synthetic peptides composed of highly fluorinated amino acids, which show intense fluorine resonances and acceptable solubility. The results support the potential use of fluorinated peptides for molecular imaging.
BIOCONJUGATE CHEMISTRY
(2023)
Review
Engineering, Biomedical
Shengxiang Fu, Zhongyuan Cai, Hua Ai
Summary: MRI is commonly used for disease diagnosis, and the development of stimulus-responsive contrast agents provides new opportunities to overcome the limitations of traditional contrast agents. By tuning the structural features of contrast agents, optimization of the T(1) and T(2) relaxation properties can be achieved, thereby improving the sensitivity and specificity of the contrast agents.
ADVANCED HEALTHCARE MATERIALS
(2021)
Article
Multidisciplinary Sciences
Laurence Dallet, Dimitri Stanicki, Pierre Voisin, Sylvain Miraux, Emeline J. Ribot
Summary: This study investigates the internalization processes of two micrometric commercial IOP into glioma cells, as well as their potential in cancer treatment, demonstrating significant tumor volume reduction in response to MFH treatment.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Cara Moloney, Tista Roy Chaudhuri, Joseph A. Spernyak, Robert M. Straubinger, Dermot F. Brougham
Summary: This study describes the use of solid magnetic core phospholipidic structures (SMLs) as an MRI-trackable surrogate to aid in the clinical development of nano-liposomal formulations for cancer chemotherapy delivery. SMLs exhibited similar tumor deposition to nano-liposomal counterparts and superior capabilities compared to other clinically-approved iron oxide nano-formulations. The findings suggest that SMLs have high clinical translational potential for predicting and optimizing tumor deposition of nanoparticulate chemotherapy carriers.
ACTA BIOMATERIALIA
(2023)
Article
Nanoscience & Nanotechnology
Gilbert Aaron Lee, Wan-Li Lin, Duen-Pang Kuo, Yi-Tien Li, Yu-Wei Chang, Yung-Chie Chen, Shiu-Wen Huang, Justin Bo-Kai Hsu, Cheng-Yu Chen
Summary: Lipid-coated SPIO nanoparticles conjugated with PD-L1 antibodies can specifically target PD-L1 expression in glioblastoma, including temozolomide-resistant cases, as demonstrated in this study through characterizations such as dynamic light scattering and in vivo T2* map MRI analysis. This approach shows promise for early diagnosis and predicting responses to targeted PD-L1 immunotherapy in glioblastoma patients.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Chemistry, Analytical
Neda Baghban, Arezoo Khoradmehr, Alireza Afshar, Nazanin Jafari, Tuba Zendehboudi, Poorya Rasekh, Leila Gholamian Abolfathi, Alireza Barmak, Gholamhossein Mohebbi, Baspakova Akmaral, Kaliyev Asset Askerovich, Mussin Nadiar Maratovich, Hossein Azari, Majid Assadi, Iraj Nabipour, Amin Tamadon
Summary: This study utilized antibody-conjugated iron nanoparticles as a method for non-invasive tracking of cell proliferation in marine organisms. It has the potential to be used for identifying and tracking marine stem cells using MRI.
Review
Nanoscience & Nanotechnology
Shehzahdi Shebbrin Moonshi, Yuao Wu, Hang Thu Ta
Summary: Stem cell therapies have shown promising efficacy in various disorders, but clinical translation has been challenging. Tracking MSC cells with appropriate imaging methods can optimize treatment parameters and clinical outcomes.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Reena Sharma, Neelam Hooda, Ashima Hooda, Satish Khasa
Summary: A detailed study of the magnetic behavior of double perovskites was conducted by developing La2Co1-xFexMnO6 using the sol-gel technique. The results showed that substituting Fe on the Co-site led to a systematic decrease in saturation magnetization but improved the magnetic properties at lower substitution levels.
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Michele Gaeta, Marco Cavallaro, Sergio Lucio Vinci, Enricomaria Mormina, Alfredo Blandino, Maria Adele Marino, Francesca Granata, Agostino Tessitore, Karol Galletta, Tommaso D'Angelo, Carmela Visalli
Summary: Magnetic Susceptibility: Different materials exhibit varying degrees of magnetization in an external magnetic field, classified as diamagnetic, paramagnetic, superparamagnetic, and ferromagnetic. Understanding the magnetic properties of substances can help improve diagnosis in MRI imaging.
INSIGHTS INTO IMAGING
(2021)
Article
Neurosciences
Hyungseok Jang, Sam Sedaghat, Jiyo S. Athertya, Dina Moazamian, Michael Carl, Yajun Ma, Xing Lu, Alicia Ji, Eric Y. Chang, Jiang Du
Summary: This study developed an ultrashort echo time quantitative susceptibility mapping technique with an efficient 3D cones trajectory and validated its effectiveness in the human brain. The results showed that this technique provides reliable estimation of magnetic susceptibility and offers a new biomarker for susceptibility mapping in the in vivo brain.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Astronomy & Astrophysics
Giorgio Arcadi, Andreas Bally, Florian Goertz, Karla Tame-Narvaez, Valentin Tenorth, Stefan Vogl
Summary: The study suggests that the XENON1T electron recoil excess could be related to neutrino-electron interactions, while dark matter-electron scattering is less likely to lead to significant improvements. The parameter space is severely constrained, but potentially problematic bounds on electron couplings can be circumvented through a late phase transition in the new scalar sector.
Article
Neurosciences
Atsushi Yoshida, Frank Q. Ye, David K. Yu, David A. Leopold, Okihide Hikosaka
Summary: Quantitative susceptibility mapping (QSM) is a valuable tool for visualizing subcortical structures in the macaque brain and provides enhanced contrast for important anatomical details. The method significantly improves the visualization of structures such as the ventral pallidum, globus pallidus, substantia nigra, subthalamic nucleus, and dentate nucleus. Additionally, QSM values of certain structures are correlated to the age of macaque subjects.
Article
Astronomy & Astrophysics
Priya Mishra, Mitesh Kumar Behera, Rukmani Mohanta
Summary: In this study, a model incorporating two right-handed fermion triplet superfields is introduced to illustrate neutrino phenomenology. By utilizing a double cover of the A4 modular symmetry, the model extends the modular invariance approach to odd weight modular forms. The model correctly explains neutrino phenomenology and establishes constraints on the mass of the right-handed fermion.
Article
Astronomy & Astrophysics
S. N. Gninenko, N. Krasnikov
Summary: This study presents a model that explains the anomaly of muon g-2 and the relic density of dark matter. It suggests an interaction between dark matter and the Standard Model mediated by a portal boson called phi. The study also identifies similar events that support this interaction, which opens up new directions for future research.
Review
Radiology, Nuclear Medicine & Medical Imaging
Jeff W. M. Bulte, Ali Shakeri-Zadeh
Summary: The efficacy of cancer vaccines using tumor antigen-primed dendritic cells (DCs) is influenced by the complexity of the immune response and various factors. Proton (H-1) and fluorine (F-19) magnetic resonance imaging (MRI) can be utilized to track and accurately inject therapeutic DCs, predicting vaccine effectiveness in advance.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Article
Engineering, Biomedical
Yue Yuan, Congxiao Wang, Shreyas Kuddannaya, Jia Zhang, Dian R. Arifin, Zheng Han, Piotr Walczak, Guanshu Liu, Jeff W. M. Bulte
Summary: This study demonstrates that high-mannose N-linked glycans can serve as a biomarker for label-free tracking of transplanted human mesenchymal stromal cells (hMSCs) using mannose-weighted chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI). This label-free imaging method may facilitate the development and testing of cell therapies.
NATURE BIOMEDICAL ENGINEERING
(2022)
Article
Immunology
Aline M. Thomas, Ethan Yang, Matthew D. Smith, Chengyan Chu, Peter A. Calabresi, Kristine Glunde, Peter C. M. van Zijl, Jeff W. M. Bulte
Summary: The study explores the utility of CEST MRI in monitoring disease activity in MS, showing that CEST signals correspond temporally with disease activity and correlate with cellular and metabolic composition of lymph nodes during the active stage of experimental autoimmune encephalomyelitis (EAE). Correlations were also found between CEST MRI biomarkers, immune activation, and LN metabolite levels.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Radiology, Nuclear Medicine & Medical Imaging
Aline M. Thomas, Frederik Barkhof, Jeff W. M. Bulte
Summary: Imaging technology is an essential component in the management of multiple sclerosis, allowing for the evaluation of therapeutic efficacy. The development of molecular imaging probes has expanded our ability to assess and monitor multiple sclerosis and its treatments at the molecular level. However, despite the demonstrated utility of molecular imaging probes in multiple sclerosis applications, their use remains limited in both preclinical and clinical settings.
Review
Nanoscience & Nanotechnology
Sean Healy, Andris F. Bakuzis, Patrick W. Goodwill, Anilchandra Attaluri, Jeff W. M. Bulte, Robert Ivkov
Summary: Magnetic nanomaterials have potential for cancer nanotheranostics, but their physics complexities present challenges. Magnetic fluid hyperthermia (MFH) requires particle-imaging technology for real-time thermometry, and magnetic particle imaging (MPI) is the most promising technology to fulfill this requirement.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Swati Tanwar, Jeong Hee Kim, Jeff W. M. Bulte, Ishan Barman
Summary: Continuous long-term intracellular imaging and multiplexed monitoring of biomolecular changes associated with key cellular processes remains a challenge for the scientific community. Recently, surface-enhanced Raman scattering (SERS) has emerged as a powerful spectroscopic tool with significant advantages in the field of biology.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Review
Nanoscience & Nanotechnology
Yue Yuan, Jeff W. M. Bulte
Summary: Enzyme-mediated intratumoral self-assembled (EMISA) nanotheranostics are a new class of smart agents for combined imaging and therapy of cancer. The self-assembly of nanostructures in tumor cells is induced by conjugating small molecules with an enzyme-specific cleavage site. This approach avoids limitations of pre-assembled nanotheranostics and results in amplified imaging signal and therapeutic efficacy.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2022)
Review
Cell Biology
Dian R. Arifin, Kenneth W. Witwer, Jeff W. M. Bulte
Summary: Extracellular vesicles (EVs) are mediators of intercellular signalling and play a key role in normal and pathological cellular processes. Non-invasive imaging methods allow for a better understanding of their biodistribution and pharmacokinetics, advancing their clinical applications.
JOURNAL OF EXTRACELLULAR VESICLES
(2022)
Article
Chemistry, Multidisciplinary
Jeff W. M. Bulte, Chao Wang, Ali Shakeri-Zadeh
Summary: Superparamagnetic iron oxide (SPIO)-labeling of cells for magnetic resonance imaging (MRI) cell tracking has a long history, but studies have shown that the labeled cells may have different behaviors compared to unlabeled cells. With the emergence of magnetic particle imaging (MPI) cell tracking, there has been a renaissance in the formulation of SPIO nanoparticles optimized for MPI. Lessons learned from past experiences with SPIO-labeling for MRI could potentially facilitate the clinical translation of (combined) MRI/MPI cell tracking.
ADVANCED FUNCTIONAL MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Travis C. Jackson, Cameron Dezfulian, Vincent A. Vagni, Jason Stezoski, Keri Janesko-Feldman, Patrick M. Kochanek
Summary: This study evaluated the neuroprotective effects of several unexplored PHLPP inhibitors and found that NSC74429 has neuroprotective effects across multiple injury mechanisms. Further research and optimization of drug dosing are necessary.
Editorial Material
Critical Care Medicine
Patrick M. Kochanek, Dennis W. Simon, Amy K. Wagner
Article
Chemistry, Multidisciplinary
Swati Tanwar, Lintong Wu, Noah Zahn, Piyush Raj, Behnaz Ghaemi, Arnab Chatterjee, JeffW. M. Bulte, Ishan Barman
Summary: Quantitative phase imaging (QPI) is a powerful optical imaging technique for label-free, rapid, and three-dimensional (3D) monitoring of cells and tissues. However, there is still limited exploration in using QPI for molecular imaging of intracellular biomolecules such as enzymes. In this study, we present a novel approach by developing QPI contrast agents that enable sensitive detection of intracellular biomolecules. We introduce a new class of bio-orthogonal QPI-nanoprobes for high-contrast refractive index (RI) imaging of enzyme activity, which can potentially have significant implications for disease diagnosis and therapeutic efficacy evaluation.
Editorial Material
Nanoscience & Nanotechnology
Jeff W. M. Bulte, Ali Shakeri-Zadeh
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Jeremy R. R. Herrmann, Travis C. C. Jackson, Anthony Fabio, Robert S. B. Clark, Rachel P. P. Berger, Keri L. L. Janesko-Feldman, Patrick M. M. Kochanek, Ericka L. L. Fink, POCCA Investigators
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cell Biology
Kara Snyder, Kiersten Gorse, Patrick M. Kochanek, Travis C. Jackson
Summary: The inhibition of the pro-death gene RBM5 does not affect neuronal survival in primary neurons, but it does regulate intracellular responses to injury in a sex-dependent manner.
CELL DEATH DISCOVERY
(2023)