Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 68, Issue 4, Pages 1273-1278Publisher
WILEY-BLACKWELL
DOI: 10.1002/mrm.24112
Keywords
pharmacological MRI; retina; blood flow; blood oxygenation level dependent; pO2; nitroprusside; nitric oxide
Funding
- NIH/NEI
- Department of Veterans Affairs
- San Antonio Life Science Institute
- American Heart Association
- Clinical Translational Science Award (CTSA)
- San Antonio Area Foundation
- NIH/NEI [R01 EY009702, EY014211, EY018855]
- American Heart Association [10POST4290091]
- Clinical Translational Science Award (CTSA) [UL1RR025767]
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Nitroprusside, a vasodilatory nitric oxide donor, is clinically used during vascular surgery and to lower blood pressure in acute hypertension. This article reports a novel application of blood flow (BF) and blood oxygenation level dependent (BOLD) MRI on an 11.7T scanner to image the rat chorioretinal BF and BOLD changes associated with graded nitroprusside infusion. At low doses (1 or 2 mu g/kg/min), nitroprusside increased BF as expected but decreased BOLD signals, showing an intriguing BFBOLD uncoupling. At high doses (3-5 mu g/kg/min), nitroprusside decreased BF and markedly decreased BOLD signals. To our knowledge, this is the first pharmacological MRI application of the retina. This approach has potential to open up new avenues to study the drug-related hemodynamic functions and to evaluate the effects of novel therapeutic interventions on BOLD and BF in the normal and diseased retinas. Magn Reson Med, 2012. (c) 2011 Wiley Periodicals, Inc.
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