Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 67, Issue 6, Pages 1523-1527Publisher
WILEY-BLACKWELL
DOI: 10.1002/mrm.23192
Keywords
brain glycogen; concentration quantification; C13 spectroscopy; 14; 1 T; T1 relaxation
Funding
- Centre d'Imagerie BioMedicale (CIBM) of the UNIL
- UNIGE
- HUG
- CHUV
- EPFL
- Leenaards Foundation
- Jeantet Foundation
- FNS [122498]
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The high molecular weight and low concentration of brain glycogen render its noninvasive quantification challenging. Therefore, the precision increase of the quantification by localized 13C MR at 9.4 to 14.1 T was investigated. Signal-to-noise ratio increased by 66%, slightly offset by a T1 increase of 332 +/- 15 to 521 +/- 34 ms. Isotopic enrichment after long-term 13C administration was comparable (similar to 40%) as was the nominal linewidth of glycogen C1 (similar to 50 Hz). Among the factors that contributed to the 66% observed increase in signal-to-noise ratio, the T1 relaxation time impacted the effective signal-to-noise ratio by only 10% at a repetition time = 1 s. The signal-to-noise ratio increase together with the larger spectral dispersion at 14.1 T resulted in a better defined baseline, which allowed for more accurate fitting. Quantified glycogen concentrations were 5.8 +/- 0.9 mM at 9.4 T and 6.0 +/- 0.4 mM at 14.1 T; the decreased standard deviation demonstrates the compounded effect of increased magnetization and improved baseline on the precision of glycogen quantification. Magn Reson Med, 2011. (c) 2011 Wiley Periodicals, Inc.
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