Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 64, Issue 3, Pages 680-687Publisher
WILEY
DOI: 10.1002/mrm.22459
Keywords
NMR; MRI; relaxometry; bone collagen; bone water; bone pore
Funding
- NIH [EB001744]
- NSF [0448915]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [0448915] Funding Source: National Science Foundation
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Recent advancements in MRI have enabled clinical imaging of human cortical bone, providing a potentially powerful new means for assessing bone health with molecular-scale sensitivities unavailable to conventional X-ray-based diagnostics. In human cortical bone, MRI is sensitive to populations of protons (H-1) partitioned among water and protein sources, which may be differentiated according to intrinsic NMR properties such as chemical shift and transverse and longitudinal relaxation rates. Herein, these NMR properties were assessed in human cortical bone donors from a broad age range, and four distinct H-1 populations were consistently identified and attributed to five microanatomical sources. These findings show that modern human cortical bone MRI contrast will be dominated by collagen-bound water, which can also be exploited to study human cortical bone collagen via magnetization transfer. Magn Reson Med 64:680-687, 2010. (C) 2010 Wiley-Liss, Inc.
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