Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 62, Issue 3, Pages 788-795Publisher
WILEY
DOI: 10.1002/mrm.22029
Keywords
resolution recovery; free radicals; EPR imaging; iterative deconvolution; mice
Funding
- Japan Society for the Promotion of Science [18360195, 20656065]
- Grants-in-Aid for Scientific Research [20656065, 18360195] Funding Source: KAKEN
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A method of post-processing to enhance the image resolution of the distribution of free radical molecules obtained with continuous-wave electron paramagnetic resonance (CW-EPR) Imaging is reported. The low spatial resolution of EPR imaging, which has created difficulties in biomedical applications, was overcome by the method of resolution-recovery for EPR imaging. High spatial resolution images for the distribution of free radical molecules with a very short relaxation time were obtained with this method. The method's two-step postprocessing consists of conventional deconvolution and filtered back-projection and a process of iterative deconvolution. The resolution-recovery method was demonstrated with three-dimensional (3D) imaging of stable nitroxyl radicals in mouse head. In phantom experiments with a solution of triarylmethyl (TAM) radicals, the spatial resolution was improved by a factor of 7 with the resolution-recovery method. Magn Reson Med 62:788-795, 2009. (C) 2009 Wiley-Liss, Inc.
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