Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 63, Issue 1, Pages 25-32Publisher
WILEY
DOI: 10.1002/mrm.22169
Keywords
cartilage; relaxivity; glycosaminoglycans; MRI; dGEMRIC; Na-23 NMR; ICP; biochemical assay
Funding
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR052353, R01AR045172] Funding Source: NIH RePORTER
- NIAMS NIH HHS [AR 45172, AR 52353, R01 AR045172-10, R01 AR052353, R01 AR045172] Funding Source: Medline
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The relaxivities (R-values) of the gadolinium diethylene triamine pentaacetic acid (Gd(DTPA)(2-)) ions in a series of skim-milk solutions at 0-40% milk concentrations were measured using NMR spectroscopy. The R-value was found to be approximately linearly proportional to the concentration of the solid component in the milk solution. Using the R-value at 20% solid component (approximately the solid concentration in bovine nasal cartilage), the glycosaminoglycan concentration in bovine nasal cartilage can be quantified using the MRI delayed gadolinium-enhanced MRI of cartilage method without the customary scaling factor of 2. This finding is also supported by the measurements using Na-23 NMR spectroscopy, Na-23 inductively coupled plasma analysis, and biochemical assay. The choice of the R-value definition in the MRI delayed gadolinium-enhanced MRI of cartilage method is discussed, and the definition of Gd(DTPA)(2-) ions as millimole per volume of tissue (or milk solution for substitution) should be used. Magn Reson Med 63:25-32, 2010. (C) 2009 Wiley-Liss, Inc.
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