Journal
MACROMOLECULES
Volume 51, Issue 15, Pages 6111-6118Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.macromol.8b01006
Keywords
-
Categories
Funding
- National Institutes of Health [R01EY024072]
- NATIONAL EYE INSTITUTE [R01EY024072] Funding Source: NIH RePORTER
Ask authors/readers for more resources
We report on the fabrication of micrometer-sized dendrimer hydrogels (mu DHs) using the water-in-oil (w/o) inverse microemulsion method coupled with the highly efficient aza-Michael addition. EDA core polyamidoamine (PAMAM) dendrimer G5 (10 wt %) and poly(ethylene glycol) diacrylate (PEG-DA, M-n = 575 g/mol) (the molar ratio of amine/acrylate = 1/1) were dissolved in the water phase and added to hexane in the presence of surfactants span 80/tween 80 (5/1, w/w) (volume ratio of hexane to surfactants: 70:1) to form w/o microemulsions, in which PAMAM G5 cross-links with PEG-DA via the aza-Michael addition reaction. The resulting microgels are within 35 mu m with relatively narrow size distribution. mu DHs are pH-responsive degradable. They show good cytocompatibility and do not cause acute toxicity in vivo. Furthermore, they can realize a high loading of the hydrophobic drug CPT and enter the cells in the form of particles. The CPT and CPT/dendrimer complex can be slowly released following the zero-order release kinetics. Taken together, mu DHs possessing hierarchically ordered dendrimers in micrometer domains represent a new class of microparticles with expanded structural features for programmable drug delivery and release.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available