Article
Chemistry, Physical
Ameneh Taghavi-Kahagh, Seyedeh-Arefeh Safavi-Mirmahalleh, Reza Pashaei-Sarnaghi, Mehdi Salami-Kalajahi, Hossein Roghani-Mamaqani
Summary: Polyampholyte star copolymers were synthesized through a two-step RAFT polymerization and DPP polymerization, and their morphological changes and drug release behavior under different pH conditions were studied.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Polymer Science
Fanny Coumes, Gaelle Le Fer, Aurelie Malfait, Richard Hoogenboom, David Fournier, Patrice Woisel
Summary: A well-defined copolymer bearing supramolecular recognition units was designed for the development of multi-responsive polymer materials, showing high association constant with the electron-deficient CBPQT(4+), 4Cl(-) host. The addition of host to the copolymer resulted in the formation of donor-acceptor inclusion complexes, with the purple solution intensity proportional to the amount of host added. The thermoresponsive behavior of the copolymer was highlighted, showing a direct relationship between cloud point temperature and the amount of host added, programmable within a specific temperature window by adjusting pH.
EUROPEAN POLYMER JOURNAL
(2021)
Article
Polymer Science
Antiopi Vardaxi, Stergios Pispas
Summary: This work presents the synthesis and stimuli-responsive self-assembly behavior of novel double-hydrophilic poly(2-(dimethylamino)ethyl methacrylate-co-(oligo ethylene glycol)methacrylate) random copolymers and their chemically modified derivatives. The synthesis was successfully conducted through RAFT polymerization and further followed by the quaternization with methyl iodide, 1-iodohexane, and 1-iodododecane. The polymers exhibited intramolecular self-folding and intermolecular self-assembly upon exposure to different pHs and temperatures.
Article
Chemistry, Applied
Marco A. De Jesus-Tellez, Susana De la Rosa-Garcia, Itzel Medrano-Galindo, Ingrid Rosales-Penafiel, Sergio Gomez-Cornelio, Carlos Guerrero-Sanchez, Ulrich S. Schubert, Patricia Quintana-Owen
Summary: In this study, a series of PDMAEMAs with different molar masses were synthesized by RAFT polymerization and treated with two alkyl halides to assess their antifungal activity against various fungi. The results demonstrated that PDMAEMAs, especially those with low molar mass, exhibited significant antifungal properties, with DQ having less impact than molar mass on antifungal activity. This detailed screening contributes to a better understanding of PDMAEMA-based composites for antimicrobial protective coatings.
REACTIVE & FUNCTIONAL POLYMERS
(2021)
Article
Polymer Science
Valdomiro V. de Souza, Gustavo P. B. Carretero, Phelipe A. M. Vitale, Iris Todeschini, Paloma O. Kotani, Greice K. Saraiva, Cristiane R. Guzzo, Hernan Chaimovich, Fabio H. Florenzano, Iolanda M. Cuccovia
Summary: Amphiphilic diblock copolymers can assemble in aqueous solutions to form polymersomes, which can respond to pH, temperature, and other conditions. These robust vesicles are being studied as drug delivery systems or nanoreactors. Through characterization, it was found that these polymersomes with dual stimulus-response may serve as a platform for gene delivery and nanoreactors.
Article
Polymer Science
Athanasios Skandalis, Dimitrios Selianitis, David R. Sory, Sara M. Rankin, Julian R. Jones, Stergios Pispas
Summary: This study investigates the ability of PDMAEMA-b-PLMA-b-POEGMA amphiphilic triblock terpolymers to encapsulate curcumin. The terpolymers self-assemble into spherical micelles in aqueous solutions. The encapsulation of curcumin within the polymeric micelles is confirmed and quantified using FTIR and UV-Vis spectroscopy. The micelles exhibit spherical morphology as observed by transmission electron microscopy. Furthermore, the curcumin-loaded micelles show no cytotoxicity in vitro.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
Opeyemi J. Ajogbeje, Igor Lacik, Robin A. Hutchinson
Summary: The aqueous solution radical polymerization of DMAEMA was studied using in situ NMR spectroscopy. It was found that non-ionized DMAEMA hydrolyzes to form ionized MAA and 2-(dimethylamino)ethanol at pH > 6.0. Fully ionized DMAEMA polymerizes faster in water than non-ionized DMAEMA in dimethyl sulfoxide. Hydrolysis of DMAEMA complicates the reaction at pH 8.0 to 10.1, leading to the copolymerization of MAA and the formation of poly(DMAEMA-co-MAA).
Article
Biotechnology & Applied Microbiology
Zishuai An, Bing Cao, Junzhe Zhang, Baihong Zhang, Chengqian Zhou, Xianglong Hu, Wenli Chen
Summary: Nanomaterials have been widely studied for their potential to become the new generation of nanocarriers in gene transfection. This study focuses on the application of Poly (2-(N,N-dimethylamino) ethyl methacrylate) (PDMAEMA) as a gene carrier in plant cells. The results show that PDMAEMA has the ability to efficiently deliver DNA in plant cells with lower cytotoxicity compared to polyethylenimine (PEI). This work provides new ideas and more effective methods for plant transformation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Polymer Science
Maria Rosella Telaretti Leggieri, Tahani Kaldeus, Mats Johansson, Eva Malmstrom
Summary: Poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) was characterized using various techniques, including NMR and MALDI-TOF MS, to analyze the end groups and chain end fidelity. The results indicated that disproportionation was the primary mechanism for the loss of active chain ends. Chain extension experiments supported the estimation of chain end functionality. Total nitrogen analysis allowed for an accurate estimation of the degree of polymerization and molecular weight of the block copolymer. These characterization tools are important for assessing the control over polymerization and obtaining well-defined structures.
Article
Polymer Science
So Yeong Park, Chungryong Choi, Junho Jang, Eunseol Kim, Yeseong Seo, Jaeyong Lee, Jin Kon Kim, Hyeon U. Jeong, Jaeup U. Kim
Summary: The research discovered that under different substrate interactions and molecular weights, thin-film morphology of six-arm star-shaped poly(methyl methacrylate)-b-polystyrene [(PMMA-b-PS)(6)] varies, forming different structural arrangements.
Article
Chemistry, Multidisciplinary
Petr Salek, Jiri Trousil, Jitka Novackova, Jirina Hromadkova, Andrii Mahun, Libor Kobera
Summary: The study focused on the antimicrobial properties of PDMAEMA-based nanogels against both Gram-positive and Gram-negative bacteria, showing that quaternized PDMAEMA-EDMA nanogels had effective bactericidal activity. Various parameters in free-radical polymerization were investigated to produce well-defined sub-micron nanogels, which exhibited efficient inhibition of bacterial growth across different strains.
Article
Polymer Science
Peter J. Mons, Nora Fribiczer, Kathrin Kowalczuk, Purushottam Poudel, Sebastian Seiffert, Felix H. Schacher
Summary: In this study, we report the synthesis of a novel double hydrophilic star-shaped block copolymer and investigate its solution properties under different solution pH conditions. We find that even short stickers can enhance the aggregation tendency at low pH values, resulting in aggregate sizes beyond 1 μm.
Article
Polymer Science
So Yeong Park, Hyeon U. Jeong, Jaeyong Lee, Junho Jang, Sanghoon Kim, Chungryong Choi, Jaeup U. Kim, Jin Kon Kim
Summary: The authors conducted directed self-assembly on thin films of symmetric six-arm star-shaped poly(methyl methacrylate)-block-polystyrene copolymer, adjusting the affinity between each block and the trench wall to fabricate various dual nanopatterns. The observed morphologies, including lines, lamellar layers, and nanotubes, depend on the surface properties of the trench and the treatment method.
MACROMOLECULAR RAPID COMMUNICATIONS
(2021)
Article
Polymer Science
Thao Phuong Le Nguyen, Thao Thanh Bui, Cam Hong Thi Nguyen, Duong Thanh Le, Tam Huu Nguyen, Le-Thu T. Nguyen, Quoc-Thiet Nguyen, Mai Ha Hoang, Tsutomu Yokozawa, Ha Tran Nguyen
Summary: In this research, diblock copolymers consisting of regioregular poly(3-hexylthiophene) (P3HT) and poly(2-(dimethylamino)ethyl methacrylate-random-1-pyrenylmethyl methacrylate) (P(DMAEMA-r-PyMA)) were successfully synthesized using Grignard metathesis (GRIM) method and atom transfer radical polymerization reaction (ATRP). The copolymer exhibited well-defined structure with average molecular weight of 11300 g/mol and low polydispersity below 1.5. The structure of the polymer was characterized using gel permeation chromatography (GPC), Fourier transform infrared (FTIR) spectroscopy and proton nuclear magnetic resonance (H-1 NMR) spectroscopy. Additionally, the optical and thermal properties of the polymers were analyzed using ultraviolet-visible (UV-Vis), differential scanning calorimetry (DSC) spectroscopy and fluorescence spectroscopy. Interestingly, P3HT-b-P(DMAEMA-r-PyMA) was found to have potential as a chemosensor for trace detection of trinitrotoluene (TNT) explosive.
JOURNAL OF POLYMER RESEARCH
(2023)
Article
Polymer Science
Khalid M. Alotaibi, Abdurrahman A. Almethen, Abeer M. Beagan, Latifah H. Alfhaid, Maqusood Ahamed, Ahmed M. El-Toni, Abdullah M. Alswieleh
Summary: A new pH-responsive nanosystem based on mesoporous silica nanoparticles (MSNs) was developed for cancer therapy, featuring a gatekeeper PDEAEMA and further modification to encapsulate the anti-cancer drug doxorubicin (DOX). The fabricated nanoplatform exhibited significant drug release and cytotoxicity in acidic media, suggesting its potential as a nanocarrier for anti-cancer drugs.
Article
Materials Science, Biomaterials
Shan Gao, Wanlin Zhang, Xingxing Zhai, Xue Zhao, Jianxin Wang, Jie Weng, Jianshu Li, Xingyu Chen
Summary: Researchers have developed a double-layer drug-loaded microneedle patch with antibacterial and angiogenesis-promoting properties, which can accelerate the healing of diabetic wounds.
BIOMATERIALS SCIENCE
(2023)
Article
Materials Science, Biomaterials
Xinyuan Xu, Peiyu Qiu, Mingyang Sun, Jun Luo, Peng Yu, Libang He, Jianshu Li
Summary: Composites have been widely used in various industries, especially in the dental and orthopedic fields. However, the traditional methods of improving mechanical strength and visibility have drawbacks such as complexity, poor distribution, and long production times. Therefore, developing an integrated material with both reinforced fillers and radiopacity is of great economic and social significance.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Materials Science, Biomaterials
Cheng Cheng, Jiayun Ma, Jinling Zhao, Haiying Lu, Yang Liu, Chuanshi He, Man Lu, Xiaohong Yin, Jianshu Li, Mingming Ding
Summary: Based on disulfide-enriched multiblock copolymer vesicles, this study presents a straightforward sequential drug delivery system with dual-redox response that releases hydrophilic doxorubicin hydrochloride (DOX center dot HCl) and hydrophobic paclitaxel (PTX) under oxidative and reductive conditions, respectively. When compared to concurrent therapeutic delivery, the spatiotemporal control of drug release allows for an improved combination antitumor effect. The simple and smart nanocarrier has promising applications in the field of cancer therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Nanoscience & Nanotechnology
Yongping Lu, Wenjin Ye, Weiqi Kang, Shuaibing Wang, Zhongqiang Zhu, Xingyu Chen, Jianshu Li
Summary: In this study, a low-cost and highly efficacious wound-healing material, keratin-hyperbranched polymer hydrogel-M (KHBP-M), was developed by mixing reduced keratin, hyperbranched polymer (HBP), and MnO2 nanoparticles. The composite gel showed antibacterial effects against both Gram-positive and Gram-negative bacteria and had excellent ROS-scavenging ability. In an animal model of infected wounds, the KHBP-M hydrogel treated with near-infrared light exhibited the fastest wound-healing rate, reaching 82.98% on day 15.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Biochemistry & Molecular Biology
Kai Xu, Jie Weng, Jianshu Li, Xingyu Chen
Summary: Microneedles (MNs) are a new drug delivery method that has gained attention for their effectiveness, safety, and painlessness. To improve their application, the concept of intelligent stimuli-responsive MNs has been proposed. These MNs can exhibit unique biomedical functions according to changes in the internal and external environment.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Nanoscience & Nanotechnology
Shuqin Cao, Yuyu Li, Luxuan Shen, Bin Shao, Leixiao Yu, Jianshu Li, Quan Yuan
Summary: This study used plant virus-based nanoparticles to modify a therapeutic peptide RM for the treatment of osteoporosis. The nanoparticles showed excellent biocompatibility and stability, enhancing cellular uptake and inhibiting osteoclastogenesis. The modified nanoparticles also achieved bone enrichment and suppressed bone resorption in mice, providing a promising therapeutic strategy for osteoporosis.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Nanoscience & Nanotechnology
Qiangwei Xin, Zhengxin Ma, Shiran Sun, Hongbo Zhang, Yan Zhang, Liangrui Zuo, Yifei Yang, Jing Xie, Chunmei Ding, Jianshu Li
Summary: Researchers have developed an antifouling self-healing coating for orthodontic appliances. The coating contains hydrophilic and hydrophobic molecules, which give the polymer a structure that repels bacteria while improving adhesion. The coating has the ability to self-heal and is biologically safe, making it a promising solution for improving orthodontic appliance performance and oral health maintenance.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Peng Yu, Yanyan Li, Hui Sun, Hongbo Zhang, Han Kang, Peng Wang, Qiangwei Xin, Chunmei Ding, Jing Xie, Jianshu Li
Summary: A photothermal dual-bionic nanozyme, mimicking antioxidases and hyaluronan synthase, has been developed for effective osteoarthritis (OA) therapy. It can produce heat, scavenge free radicals, and promote chondrogenesis even under inflammatory conditions. This nanozyme regulates anabolic and catabolic processes simultaneously, thereby effectively restoring joint homeostasis and demonstrating an admirable photothermally therapeutic effect on OA.
ADVANCED MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Yongping Lu, Linming Fan, Jun Wang, Mingxiang Hu, Baogang Wei, Ping Shi, Jianshu Li, Jinyan Feng, Yu Zheng
Summary: The nanodelivery system has limitations in its effectiveness due to short biological half-life and inadequate tumor targeting. The integration of cancer cell membranes (CCM) and nanoparticles has led to the emergence of CCM-based nanoplatforms (CCM-NPs), which have gained significant attention for their unique properties. CCM-NPs not only prolong the blood circulation time of core nanoparticles, but also target tumors effectively. This article discusses the history and development of CCM-NPs, as well as their applications in biomedical research, particularly in cancer therapy.
Review
Chemistry, Multidisciplinary
Xiaoning Sun, Chunmei Ding, Meng Qin, Jianshu Li
Summary: Hydrogel-based biosensors are highly promising for the detection and monitoring of bacterial infections. This review summarizes the recent advancements in this field and discusses the challenges and future development of hydrogel biosensors for bacterial infections.
Article
Nanoscience & Nanotechnology
Qiangwei Xin, Zhengxin Ma, Shiran Sun, Hongbo Zhang, Yan Zhang, Liangrui Zuo, Yifei Yang, Jing Xie, Chunmei Ding, Jianshu Li
Summary: In orthodontic treatment, bacterial infections are a risk to oral health. A self-healing coating based on supramolecular bonding was prepared to improve the antifouling properties of orthodontic appliances. The coating showed excellent antimicrobial activity, surface antifouling properties, and the ability to restore antibiofouling properties at oral temperature and humidity.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Miao Zhang, Xu Peng, Yuan Ding, Xiang Ke, Kai Ren, Qiangwei Xin, Meng Qin, Jing Xie, Jianshu Li
Summary: Enhanced joint synergistic lubrication combined with anti-inflammatory therapy is an effective strategy to delay the progression of early osteoarthritis. A pH-responsive cyclic brush zwitterionic polymer (CB) with high drug-loading efficiency was developed, demonstrating superlubrication, sequence controlled release, and anti-inflammatory effects. The CB shows promise as a long-acting lubricating therapeutic agent for OA treatment or other diseases.
MATERIALS HORIZONS
(2023)
Review
Materials Science, Biomaterials
Yongping Lu, Xinyuan Xu, Jianshu Li
Summary: Adhesive materials, both natural and synthetic, have the ability to stick to mucus or epithelial cells. They are widely used in biomedicine due to their unique properties, such as adhesion, biocompatibility, and surface characteristics. They can target specific areas in the human body, improving therapeutic effects and preventing bacterial infections. This review systematically introduces the properties and mechanisms of different types of adhesive materials and explores their applications in drug delivery, antibacterials, tissue repair, and other biomedical fields. The prospects and challenges of using adhesive materials in biomedicine are also discussed.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Engineering, Chemical
Haiqin Tang, Qi Chen, Xiang Ke, Hao Wang, Moyan Li, Jing Xie, Jun Luo, Jianshu Li
Summary: This study proposes a strategy to prepare pH-responsive reversible wet adhesive hydrogels using the structural advantage of urushiol. The resulting hydrogel demonstrates reliable and universally applicable pH-responsive reversible adhesion, as well as remarkable improvements in mechanical properties.
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
(2023)
Article
Materials Science, Biomaterials
Qi Chen, Xiang Ke, Yusong Cai, Hao Wang, Zhiyun Dong, Xinlong Li, Jinlin Li, Xinyuan Xu, Jun Luo, Jianshu Li
Summary: This study introduces a biocompatible small molecule with a triple hydrogen bonding cluster into a polyacrylamide hydrogel, resulting in a highly stretchable hydrogel with superior mechanical properties and adhesion capacity. Furthermore, by incorporating calcium ions, the performance of the hydrogel in skin sensors is significantly improved.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)