Article
Nanoscience & Nanotechnology
Yan Wang, Luwei Zhang, Taka-Aki Asoh, Hiroshi Uyama
Summary: The study successfully synthesized chiral hierarchical porous monoliths in a flexible and highly efficient one-step method, without the need for complex doping or procedures. The monoliths exhibited hierarchical pore structure with throughpore and high surface area, and their porous structures and pore size could be adjusted by changing the conditions of phase separation. Additionally, the prepared monoliths showed good optical activity, thermal stability and mechanical properties, and were applied in enantioselective crystallization with promising performance.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Chemistry, Physical
Megan R. McGrory, Rosalie H. Shepherd, Martin D. King, Nicholas Davidson, Francis D. Pope, I. Matthew Watson, Roy G. Grainger, Anthony C. Jones, Andrew D. Ward
Summary: By studying the interaction between sulfuric acid and silica beads at the micron scale, it was found that core-shell particles can form. The experiment simulated the light scattering properties of aerosols and determined the diameter, shell thickness, and refractive index of the core aerosol. Additionally, the study found that the presence of a sulfuric acid film significantly affected the light scattering properties of the aerosol.
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Marie Mettler, Adrien Dewandre, Nikolay Tumanov, Johan Wouters, Jean Septavaux
Summary: This work extends the application scope of microfluidic-based crystallization methods by introducing solid microcapsules, and demonstrates the potential of this method for compound characterization.
CHEMICAL COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Hoonsub Kim, Pyung Won Im, Yuanzhe Piao
Summary: Uniform-sized iron oxide nanoparticles were encapsulated inside a silica shell using the reverse microemulsion technique, then transformed into iron nitride through thermal treatment under NH3. The resulting core/shell nanostructures exhibited high uniformity in particle-size distribution. The acid-resistant properties of the iron nitride at silica core/shell nanostructures were significantly higher than the starting iron oxide at silica.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Environmental
Jing Gao, Zhijun Ma, Fuli Liu, Xingyuan Weng, Kaiyin Meng
Summary: Spherical Gd-Co ferrite nanoparticles with silica and carbon shells were synthesized in this study. Among them, Gd-Co ferrite@silica@carbon exhibited the best microwave absorption performance, with low reflection loss and wide effective absorption band. This excellent performance is attributed to the interaction between magnetic loss and dielectric loss, as well as the excellent impedance matching.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Polymer Science
Yan-Fang Zhang, Xu Chen, Xiao-Song Yu, Jia-Xin Chen, Ming-Qu Hu, Bo-Yuan Zheng, Yi-Xin Liu, Shuang Yang, Er-Qang Chen
Summary: It is discovered that dynamic helical cis-poly(phenylacetylene) can form folded chain lamellae in the liquid crystal phase. Through atomic force microscopy experiments, adjacent and nonadjacent folds at the liquid crystal-amorphous interface were directly visualized.
Article
Chemistry, Inorganic & Nuclear
Danhui Zhang, Ruquan Liang, Houbo Yang, Yuanmei Song, Jianhui Shi, Dengbo Zhang, Zhongkui Liu, Anmin Liu
Summary: This paper demonstrates the process of combining polyacetylene with silver nanowire to form core-shell nanoclusters using molecular dynamic simulations. The influence of silver nanowire thickness on nanocluster formation and the significant role of van der Waals force in the fabrication process are observed. Factors affecting the process and other metal nanoclusters induced by polyacetylene are also discussed in detail.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Hai Zhong, Yingjie Zhang, Jianping Deng
Summary: This article reports on the construction of novel ternary chiral porous hybrid particles (TCPHPs) using alkynylated cellulose nanocrystals (A-CNCs), helical substituted polyacetylene, and inorganic silica, displaying anticipated optical activity and enantio-differentiating performance towards chiral drugs.
Article
Engineering, Environmental
Suzhou Li, Jinhui Huang, Kaixin Yi, Haoliang Pang, Zhexi Liu, Wei Zhang, Chenyu Zhang, Si Liu, Jiaoni Li, Chunhua Liu, Wenli Shu
Summary: Based on this study, two different sizes of silica materials (silica beads and Nano-silica) were used to encapsulate a QQ bacterial strain (Rhodococcus sp. BH4). The results showed that both QQ beads could resist high pressure, acid, alkali, salt, and EDTA buffer. After five months of use, both beads still had more than 70% QQ activity. In the lab-scale continuous MBR experiment, the transmembrane pressure (TMP) reaching 50 kPa in the experimental groups was more than 3 times that in the blank group, and the TMP contamination time was extended from 5 to 6 days in the blank group to 18-19 days. Among them, silica beads greatly improved the compressive strength of the beads and performed better in QQ.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Shuya Li, Hanjie Lin, Chun Chu, Chandler Martin, Walker Macswain, Robert W. Meulenberg, John M. Franck, Arindam Chakraborty, Weiwei Zheng
Summary: A simple method has been developed to fabricate lead-free/core-shell nanocrystals with enhanced environmental stability and improved photoluminescence quantum yields. The resulting nanocrystals exhibit tunable photoluminescence colors due to B-site ion diffusion at the core/shell interface, which further optimizes the optical properties.
Article
Chemistry, Multidisciplinary
Peter Sutter, Raymond R. Unocic, Eli Sutter
Summary: This research presents a rational synthetic route for controlling the placement and tuning of single dislocations in van der Waals nanowires, allowing for the identification of their functional properties and potential technological applications.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Review
Pharmacology & Pharmacy
Dnyaneshwar Kalyane, Narendra Kumar, Neelima Anup, Kuldeep Rajpoot, Rahul Maheshwari, Pinaki Sengupta, Kiran Kalia, Rakesh Kumar Tekade
Summary: This review highlights the potential of core-shell silica-based nanoparticles in developing next-generation therapeutics, covering their role in drug delivery, imaging, therapy, and challenges.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Meng Lyu, Jianwei Zheng, Claire Coulthard, Jing Ren, Yufei Zhao, Shik Chi Edman Tsang, Chunping Chen, Dermot O'Hare
Summary: Well-dispersed core-shell catalyst precursors using silica@CuxZnAl-LDHs show significantly enhanced catalytic performance in converting CO2 to methanol.
Article
Engineering, Biomedical
Han-Sem Kim, Jung-Hwan Lee, Nandin Mandakhbayar, Guang-Zhen Jin, Sung-Jin Kim, Ji-Young Yoon, Seung Bin Jo, Jeong-Hui Park, Rajendra K. Singh, Jun-Hyeog Jang, Ueon Sang Shin, Jonathan C. Knowles, Hae-Won Kim
Summary: The unique-structured nanohybrids formed through self-assembly of Chit@IOC nanounits exhibit high resilience, controlled delivery of multiple therapeutic molecules, and cellular activation. These nanohybrids can accelerate cellular responses, promote new bone formation, and are considered promising 3D tissue regenerative platforms in biomedical applications.
Article
Engineering, Manufacturing
Ji-Won Cheon, Il-Jin Kim, Ji-Hoon Kim, Ji-Won Jang, Dong-Jin Lee, So Youn Mun, Jun-Woo Park, Jin Hong Lee, Seunggun Yu
Summary: This study demonstrates the use of a composite filler composed of silica nanoparticles (NPs) and poly (ethersulfone) (PES) to improve the properties of epoxy nanocomposites for marine applications. The incorporation of silica NPs and covalent linking of PES to epoxy results in enhanced flexural strength and fracture toughness. Additionally, the flame retardancy and seawater resistance of the nanocomposites are significantly improved due to the thermally and chemically robust nature of PES and silica NPs.
COMPOSITES PART A-APPLIED SCIENCE AND MANUFACTURING
(2022)
Review
Engineering, Chemical
Yun Hao Feng, Bo Zhi Chen, Wen Min Fei, Yong Cui, Can Yang Zhang, Xin Dong Guo
Summary: Nanomaterial drug delivery systems are crucial in targeted therapy, with the interaction between nanoparticles and cell membranes being an important consideration. Computer simulations can be applied to visualize nanoparticle internalization within cells, especially given the challenges of experimental methods. Understanding the positive and negative effects of various nanoparticle properties can help researchers optimize nanoparticle structures for improved therapeutic efficiency.
Review
Biophysics
Wei Xin Guo, Liu Fu Hu, Yun Hao Feng, Bo Zhi Chen, Xin Dong Guo
Summary: This article reviews the use of DPD in simulating the self-assembly process of pH-sensitive drug-loaded nanoparticles, exploring the factors affecting self-assembly structure and drug release. It is important for researchers to stay updated on the latest advances in DPD simulation and pH-sensitive drug nanocarrier and to investigate further applications of DPD simulation in biomedical science.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Materials Science, Biomaterials
Ze Qiang Zhao, Bao Li Zhang, Hua Qing Chu, Ling Liang, Bo Zhi Chen, Hui Zheng, Xin Dong Guo
Summary: Considering the global prevalence of local pain, this study developed a GelMA MNs system for sustained delivery of lidocaine hydrochloride. Results showed that the system was reliable and efficient, enhancing and prolonging the anesthetic effect in a rat model. Biosafety evaluation confirmed the absence of side effects.
BIOMATERIALS ADVANCES
(2022)
Review
Instruments & Instrumentation
Wen Xuan Li, Xiao Peng Zhang, Bo Zhi Chen, Wen Min Fei, Yong Cui, Can Yang Zhang, Xin Dong Guo
Summary: Diabetes is a serious chronic disease that requires frequent blood glucose monitoring. Microneedles, as a painless drug delivery system, offer great potential in diabetes treatment, but also face challenges.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Instruments & Instrumentation
Bo Zhi Chen, Meng Chan He, Xiao Peng Zhang, Wen Min Fei, Yong Cui, Xin Dong Guo
Summary: Researchers have developed a mass production method for coated microneedles with homogeneous and controllable drug loading using micro-molding technology. In vivo trials in diabetic mice demonstrated similar hypoglycaemic effects of insulin-coated microneedles compared to subcutaneous injection, supporting the clinical translation of microneedle technique.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Sport Sciences
Eun-Young Lee, An-Chi Shih, Maia Collins, Yeong-Bae Kim, Patrick Abi Nader, Jasmin Bhawra, Tarun Reddy Katapally, Chiaki Tanaka, Pairoj Saonuam, Piyawat Katewongsa, Dyah Anantalia Widyastari, Wendy Y. Huang, Stephen H. Wong, Asaduzzaman Khan, Narayan Subedi, Susan Paudel, Chen-Kang Chang, Ching-Lin Wu, Justin Y. Jeon, Yeon Soo Kim, Tom Loney, Falk Muller-Riemenschneider, Bozhi Chen, Jonathan Y. Cagas, Jyh Eiin Wong, Mohd Razif Shahril, Agus Mahendra, Mark S. Tremblay
Summary: This study summarizes the current status and trends of physical activity participation among children and adolescents in 18 Asian countries and identifies existing problems. The findings show that physical activity levels among children and adolescents in the Asian region are low, but there is a growing enthusiasm and support for global physical activity promotion efforts. Therefore, promoting a physically active lifestyle among children and adolescents should be a collective interest and priority in the Asian region.
JOURNAL OF EXERCISE SCIENCE & FITNESS
(2023)
Article
Pharmacology & Pharmacy
Yu Ting He, Yu Ying Hao, Rui Xing Yu, Chao Zhang, Bo Zhi Chen, Yong Cui, Xin Dong Guo
Summary: In this study, a polymer microneedle roller (PMR) was designed and fabricated using a mold hot pressing method, and a mouse model of melasma induced by ultraviolet radiation was established. The results showed that PMR had a better therapeutic effect on melasma compared to direct application of hydroquinone cream, suggesting the potential of microneedles in future clinical applications for improving UV irradiation-induced pigmentation such as melasma.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Sport Sciences
Zoey Tay, Bozhi Chen, Kiran Yan Kui, Natarajan Padmapriya, Mary Foong-Fong Chong, Andre Matthias Muller, Eer Ling Lee, Engle Troy, Falk Muller-Riemenschneider
Summary: This article provides an overview of the development of the 2022 Active Healthy Kids Singapore Report Card and its results, as well as highlights limitations and gaps in the available evidence on physical activity among children and adolescents in Singapore. The study used the Global Matrix 4.0 method and synthesized data from various sources. Grades were assigned to different indicators and provide baseline scores for future comparisons. This is the first comprehensive evaluation of physical activity among children and adolescents in Singapore.
JOURNAL OF EXERCISE SCIENCE & FITNESS
(2023)
Review
Polymer Science
Mahsa Sedighi, Neha Shrestha, Zahra Mahmoudi, Zahra Khademi, Alireza Ghasempour, Hamideh Dehghan, Seyedeh Fahimeh Talebi, Maryam Toolabi, Veronique Preat, Bozhi Chen, Xindong Guo, Mohammad-Ali Shahbazi
Summary: Self-assembly is a growth mechanism in nature to form minimum energy structures through local interactions. Self-assembled peptides can design and fabricate various structures using physical interactions between building blocks. Peptide hydrogels, with bioactivity, biocompatibility and biodegradability, have versatile applications in biomedical fields such as drug delivery, tissue engineering, biosensing, and disease treatment.
Article
Energy & Fuels
Bo Chen, Zhitong Yao, Changwei Zhang, Shikun Cheng, Mengying Zhu, Yankun Wang, Yilu Wu, Hui Cao, Ian Watson, Di Cai
Summary: In this study, bagasse ash (BA) recovered from the biorefinery process was used as a catalyst in the co-pyrolysis of solid residue from a second-generation bioethanol plant with high-density polyethylene (HDPE). The co-pyrolytic behaviors and kinetics were investigated using thermogravimetric analyzer and model-free methods. The addition of BA increased the production yield and the average apparent active energy of co-pyrolysis was lower than that for catalyst-free pyrolysis. This novel co-pyrolysis process has great potential in improving the economic and environmental aspects of second-generation biorefineries.
BIOMASS CONVERSION AND BIOREFINERY
(2023)
Article
Engineering, Biomedical
Samin Abbaszadeh, Mohammad Reza Eskandari, Vahideh Nosrati-Siahmazgi, Kiyan Musaie, Soraya Mehrabi, Ruikang Tang, Mohammad Reza Jafari, Bo Xiao, Vahid Hosseinpour Sarmadi, Fakhri Haghi, Bo Zhi Chen, Xin Dong Guo, Helder A. Santos, Mohammad-Ali Shahbazi
Summary: To improve the efficiency of intravenously administered nanocarriers in tumor eradication, researchers have developed an injectable hydrogel that can enhance viscosity and self-heal at the tumor site. The hydrogel contains cancer cell membrane and sorafenib to elicit immune responses and induce cancer cell apoptosis, as well as hyaluronic acid coated Bi2S3 nanorods for prolonged local photothermal therapy. The hydrogel promotes immunostimulatory responses and can completely ablate breast tumors in animal models. Additionally, the hydrogel exhibits strong antibacterial activity, reducing the risk of infection in post-cancer lesions formed by photothermal therapy.
MATERIALS TODAY BIO
(2023)
Article
Engineering, Chemical
Yun Hao Feng, Wei Xin Guo, Xiaobin Li, Jiahui Liu, Vahideh Nosrati-Siahmazgi, Maryam Toolabi, Wen Min Fei, Yong Cui, Bo Zhi Chen, Mohammad-Ali Shahbazi, Li Juan Zhang, Can Yang Zhang, Xin Dong Guo
Summary: Nanovesicles have been widely studied and used in biomedical applications, but premature leakage of water-soluble drugs hinders their clinical use. Developing effective strategies to prevent leakage is crucial. In this study, we utilized coarse-grained molecular simulations to explore strategies for leakage inhibition. We investigated the effects of cholesteryl hemisuccinate doping and gold nanoparticles on the morphology and structure of nanovesicles. Our findings suggest that cholesteryl hemisuccinate can improve hole defects in the hydrophobic layer, adjusting drug diffusion. Additionally, we studied the effects of particle size, concentration, and surface chemical properties of gold nanoparticles on drug leakage. Physical cross-linking of gold nanoparticles led to increased drug leakage, but surface modification improved dispersion and reduced side effects.
CHEMICAL ENGINEERING SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Alireza Ghasempour, Hamideh Dehghan, Mehrnaz Ataee, Bozhi Chen, Zeqiang Zhao, Mahsa Sedighi, Xindong Guo, Mohammad-Ali Shahbazi
Summary: Cadmium sulfide nanoparticles (CdS NPs) are widely used in nanobiotechnology due to their unique properties and have applications in biosensors, bioimaging, and antibacterial and anticancer applications. Biogenic synthesis is a preferred method for producing CdS NPs due to its efficiency, environmental friendliness, and biocompatibility. The size and coating of CdS NPs play a crucial role in their biomedical activities, and there is a need for further in vivo studies to reduce toxicity. This review discusses synthesis methods, characterization, and applications of CdS NPs in the biomedical field.
Review
Materials Science, Biomaterials
Ze Qiang Zhao, Ling Liang, Li Yue Jing, Yue Liu, Yu Han Zhang, Mohammad-Ali Shahbazi, Bo Zhi Chen, Xin Dong Guo
Summary: Wound management is a global concern that imposes a significant social and economic burden. Microneedles, a novel transdermal drug delivery method, can enhance wound-healing efficacy by overcoming barriers and improving drug delivery efficiency. This article reviews the research on the application of microneedles in wound management, categorizing them into five areas: hemostasis, antibacterial effects, proliferation, anti-scar, and wound monitoring. It concludes with a discussion on the current state and future direction of microneedles in wound management to inspire more efficient strategies.
BIOMATERIALS SCIENCE
(2023)
Article
Biology
Jie Zhang, Bo Chen, Ke Zou
Summary: This study found that ketogenic diet effectively reduces body weight but does not affect muscle strength and exercise endurance. It was observed that mice on a ketogenic diet had lower body weight and blood glucose levels, and higher blood ketone levels. Additionally, the ketogenic diet regulated protein levels in the gastrocnemius muscles through certain signaling pathways and identified potential genes related to muscle function.
OPEN LIFE SCIENCES
(2023)