Journal
MACROMOLECULAR RESEARCH
Volume 26, Issue 12, Pages 1129-1134Publisher
SPRINGER
DOI: 10.1007/s13233-018-6143-8
Keywords
hollow silica nanoparticle; gold nanocomposite; photothermal effect; pH-responsive drug release
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Funding
- National Research Foundation (NRF) of Korea - Ministry of Science and ICT (MSIT) [2015M3A9D7030461, 2016M3A7B4910652]
- NRF of Korea - MSIT [2017R1C1B1011677]
- Korea Health Technology R&D Project through the Korea Health Industry Development Institute - Ministry of Health & Welfare, Republic of Korea [HI14C3347]
- National Research Foundation of Korea [2015M3A9D7030461] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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We report herein a novel surfactant-free synthetic approach for hollow silica nanoparticles (HSN) loaded with Au nanocomposites (Au-HSN) to enhance photothermal properties. Transmission electron microscopy and elemental analysis confirmed the uniform HSN of Au nanoparticles. UV-vis spectroscopy and Fourier transform infrared spectroscopy were performed to demonstrate the dopamine (DA)-hyaluronate (HA) coating on Au-HSN. These nanocomposites dramatically increased up to 48 degrees C within few seconds under near-infrared irradiation. In addition, these Au-HSN/DA-HA nanoparticles showed the excellent endocytosis against cancer cells without any cytotoxicity. Therefore, it could be a powerful nanocarrier for tumor targeting and photothermal therapy applications.
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