Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 35, Issue 16, Pages 1402-1407Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201400217
Keywords
boronic acid; glucose; polymer brush; quartz crystal microbalance; sensor
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Funding
- European commission [247138]
- European Science Foundation Precision Polymer Materials (P2M) Research Networking Programme
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Thin, phenylboronic acid-containing polymer coatings are potentially attractive sensory layers for a range of glucose monitoring systems. This contribution presents the synthesis and properties of glucose-sensitive polymer brushes obtained via surface RAFT polymerization of 3-methacrylamido phenylboronic acid (MAPBA). This synthetic strategy is attractive since it allows the controlled growth of PMAPBA brushes with film thicknesses of up to 20 nm via direct polymerization of MAPBA without the need for additional post-polymerization modification or deprotection steps. QCM-D sensor chips modified with a PMAPBA layer respond with a linear change in the shift of the fundamental resonance frequency over a range of physiologically relevant glucose concentrations and are insensitive toward the presence of fructose, thus validating the potential of these polymer brush films as glucose sensory thin coatings.
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