Journal
MACROMOLECULAR RAPID COMMUNICATIONS
Volume 32, Issue 1, Pages 19-24Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/marc.201000365
Keywords
block copolymers; bioconjugation; nanoparticles N-succinimidyl ester; poly(poly(ethylene glycol) methacrylate)
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Funding
- Chemical Council of the Netherlands Organization for Scientific Research (NWO CW)
- European Science Foundation
- Royal Netherlands Academy for Arts and Sciences
- la Fundacio Bosch i Gimpera
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Water-dispersible PEGylated nanoparticles (NPs) presenting amine-reactive conjugation sites at their surfaces were synthesized and their ability to react with amines was demonstrated. An amphiphilic block copolymer bearing an N-succinimidyl ester at its water-soluble end was synthesized by the consecutive controlled radical polymerization of poly(ethylene glycol) methacrylate and styrene from a functional halide initiator. After purification of the copolymer, NPs of approximately 40nm were obtained by a self-assembly process in water. The reactivity of the NPs was evidenced by reacting them with primary amines, including a fluorescent dye. The activated ester remained stable throughout all synthetic steps and a nearly quantitative coupling efficiency was obtained.
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