Article
Engineering, Biomedical
Mohamad Nageeb Hassan, Mohammed Ahmed Yassin, Ahmed Maher Eltawila, Ahmed Emad Aladawi, Samih Mohamed-Ahmed, Salwa Suliman, Sherif Kandil, Kamal Mustafa
Summary: The study evaluated the osteoconductivity of 3D-printed PLATMC templates for bone tissue engineering, comparing them to widely used 3D-printed PCL templates. PLATMC showed greater wettability, strength, degradation, and promoted osteogenic differentiation of hBMSCs, with superior osteoconductivity compared to PCL. In vivo, PLATMC demonstrated unique contact osteogenesis and significantly higher amounts of new bone regeneration, showing its potential advantage in bone tissue engineering.
BIOMATERIALS RESEARCH
(2022)
Article
Polymer Science
Lihuang Wu, Zixiang Wu, Yuqi Wang, Lu Han, Hongli Mao, Zhongwei Gu
Summary: In this study, the enzymatic degradation and in vivo degradation of PTLA with different chemical compositions were investigated. The degradation behavior of PTLA changed from surface degradation to bulk degradation with the increase of lactide content within a certain range, and followed typical bulk degradation behaviors for lactide content > 30 mol%.
POLYMER DEGRADATION AND STABILITY
(2022)
Article
Polymer Science
Xiliang Liu, Song Liu, Kaiqi Li, Shaomin Feng, Youkun Fan, Lijun Peng, Xin Wang, Dongliang Chen, Chengdong Xiong, Wei Bai, Lifang Zhang
Summary: PTMC networks were prepared with three different crosslinking agents to improve mechanical properties and resist creep. The degradation characteristics of PTMC and PTMC networks were evaluated, showing different behaviors during degradation. PPL was found to effectively accelerate the degradation of PTMC networks.
POLYMER DEGRADATION AND STABILITY
(2021)
Article
Polymer Science
Xiliang Liu, Song Liu, Shaomin Feng, Xin Wang, Wei Bai, Jianping Xiao, Dongliang Chen, Chengdong Xiong, Lifang Zhang
Summary: PTMC/PLCL blends exhibited excellent flexibility, mechanical strength, and biocompatibility for soft tissue applications, along with a higher degradation rate than pure PTMC. The blend can provide a promising alternative for soft tissue implants due to its suitable properties.
JOURNAL OF POLYMER RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Honglei Kang, Xudong Jiang, Zhiwei Liu, Fan Liu, Guoping Yan, Feng Li
Summary: Biodegradable scaffolds based on biomedical polymeric materials were prepared using composite materials of PTMC/PLA/HA and PTMC/HA, showing low toxicity, good biodegradability, and biocompatibility while enhancing the cell multiplication ability of osteoblast cells.
Article
Polymer Science
Xiliang Liu, Song Liu, Shaomin Feng, Kaiqi Li, Youkun Fan, Xin Wang, Jianping Xiao, Wei Bai, Dongliang Chen, Chengdong Xiong, Lifang Zhang
Summary: Rubbery biodegradable cross-linked PTMC networks were prepared by gamma irradiation, with PETA showing better crosslinking efficiency compared to TMPTA and PET4A. Networks with high gel fractions and tensile strength could be obtained by adding 7 wt% PETA. Increasing irradiation dose led to reduced gel content and network density, resulting in decreased mechanical properties. Ethanol-extracted PTMC networks exhibited better flexibility and mechanical properties, contributing to their potential in soft tissue engineering applications.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Engineering, Biomedical
Esperanza Diaz, Marta Delafuente, Sara Delafuente, Sylvie Ribeiro, Senentxu Lanceros-Mendez
Summary: This paper studies the degradation behavior of poly(d,l-lactide-co-glycolide/reduced graphene oxide scaffolds obtained by thermally induced phase separation and lyophilization in phosphate buffered saline solution at 37°C for eight weeks. The addition of rGO particles increases the pore size and improves the morphological definition of the scaffolds. Higher rGO concentrations result in faster degradation and the restriction of movement of macromolecular chain segments. The addition of rGO also leads to a transition from insulating to conductive scaffolds with a percolation value of approximately 0.5 w/w. All PLGA samples with rGO content up to 1% show no cytotoxic behavior and are suitable for biomedical applications.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2023)
Article
Polymer Science
Qi Xia, Wuyou Ye, Qin Zhang, Dongyang Liu, Shida Gao, Zhongyong Fan, Qing Liu
Summary: This study reports the synthesis of a terpolymer with different monomer feeding ratios for biodegradable medical implants to improve their degradation and mechanical properties. The results show that increasing the glycolide content in the terpolymer can enhance its degradation rate, allowing for a balance between the degradation rate and the body's lesion healing rate by adjusting the glycolide ratio in the terpolymer.
JOURNAL OF APPLIED POLYMER SCIENCE
(2022)
Article
Polymer Science
Na Ni, Tiantang Fan, Wuyou Ye, Qi Xia, Dongyang Liu, Jingwen Qin, Zhongyong Fan, Qing Liu
Summary: This study developed biodegradable PTLG terpolymers with improved mechanical performance and processed them into peripheral vascular stents using a novel 3D 4-axial printing technology. The crystallinity and mechanical properties of the PTLG terpolymers varied with degradation rate depending on the chain sequence structure and the component contents. Compared with laser-engraved stents, the 3D printed PTLG terpolymer-based stents exhibited a finer structure and smoother surface. The addition of the PTMC segment effectively improved the flexibility of the PTLG terpolymer stent and the 3D printed stent, and the stents showed good biocompatibility.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Polymer Science
Artur Turek, Jakub Rech, Aleksandra Borecka, Justyna Wilinska, Magdalena Kobielarz, Henryk Janeczek, Janusz Kasperczyk
Summary: This study aimed to determine the role of mechanical, structural, and thermal properties of P(l-LA:GA:TMC) with shape memory in the formulation of implantable and biodegradable rods with aripiprazole. The results showed that the proposed formulation may be administered as a delayed-release system, and EB irradiation was found to accelerate ARP release.
Article
Polymer Science
Prasong Srihanam, Wiriya Thongsomboon, Yodthong Baimark
Summary: The aim of this study was to modify PLLA-b-PEG-b-PLLA copolymer using low-cost CaCO3 filler to improve its material properties. The addition of CaCO3 enhanced the crystallinity and thermal stability of PLLA-b-PEG-b-PLLA matrix. SEM analysis showed stronger interfacial adhesion between PLLA-b-PEG-b-PLLA and CaCO3 compared to PLLA and CaCO3. Tensile testing revealed increased stress and modulus for PLLA-b-PEG-b-PLLA matrix with CaCO3, while these properties significantly decreased for PLLA matrix. Therefore, CaCO3 shows promise as an inexpensive filler for improving PLLA-b-PEG-b-PLLA bioplastics.
Article
Biotechnology & Applied Microbiology
Tiantang Fan, Jingwen Qin, Xiao Meng, Jiafeng Li, Qing Liu, Guannan Wang
Summary: PLPG membranes with sc-PLA improved the crystallizing behavior of PLLA segments, increased thermal stability and degradation ability, and showed low cytotoxicity.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Thomas M. McGuire, Antoine Buchard, Charlotte Williams
Summary: A commercial Sn(II) catalyst combined with a commercial alcohol has been found to efficiently convert waste PLLA plastic into pure L-lactic acid at low temperatures. This catalyst system exhibits not only excellent catalytic activity and yield, but also significantly lower usage compared to previous catalysts.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Thomas M. McGuire, Antoine Buchard, Charlotte Williams
Summary: This study presents an efficient method for chemical recycling of waste Poly(L-lactic acid) (PLLA) using a commercial Sn(II) catalyst and nonvolatile commercial alcohol. The depolymerization of PLLA to yield pure L-lactide (L-LA) can be achieved at low temperatures, and the catalyst system shows outstanding activity and selectivity. Furthermore, the catalyst system can be recycled multiple times without loss of its catalytic productivity.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Materials Science, Multidisciplinary
Jielin Wang, Yucai Li, Yizhou Gao, Xiaojian Ye
Summary: The effects of modified inorganic particles on the degradation behavior of a terpolymer were investigated. The addition of inorganic particles can neutralize acidic products and maintain system pH. Different inorganic particles show different degradation rate adjustment effects. Mesoporous materials slow down the degradation rate, while calcium carbonate whiskers accelerate it. The in vitro degradation rate of composite materials can be regulated by adding different inorganic particles, which has important reference value. All samples show good histocompatibility, suggesting potential for use as a fully biodegradable bone repair scaffold.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Rui Yu, Louis Cornette de Saint-Cyr, Laurence Soussan, Mihail Barboiu, Suming Li
Summary: Imine dynamic hydrogels synthesized from CMCS and Jeffamine exhibit outstanding rheological, swelling, self-healing, and antibacterial properties, making them promising materials for healthcare applications such as wound dressing, drug delivery, and tissue engineering.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Rim Nasri, Marwa Hamdi, Sana Touir, Suming Li, Maha Karra-Chaabouni, Moncef Nasri
Summary: This study aimed to encapsulate goby fish protein hydrolysate with antioxidant activity into microparticles using ionic gelation process. The loaded microparticles showed improved encapsulation efficiency and reduced particle size with increasing GPH concentration. Additionally, the encapsulated biopeptides exhibited enhanced thermal stability and followed a diffusion-controlled mechanism for release kinetics, leading to improved antioxidant activity compared to unloaded microparticles.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Qingzhen Zhu, Baogang Zhang, Yuandou Wang, Xinghua Liu, Weiwei Li, Feng Su, Suming Li
Summary: PLGA-PEG diblock copolymers with varying compositions were synthesized using ring-opening polymerization, leading to the formation of micelles with different structures. These micelles were used to load valsartan for controlled drug release, with the overall release rate depending on micelle degradation.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2021)
Article
Chemistry, Applied
Sawsan Affes, Hana Maalej, Suming Li, Rania Abdelhedi, Rim Nasri, Moncef Nasri
Summary: The study found that Maillard reaction-crosslinked chitosan/COS based films showed improved structural and functional properties, with more pronounced effects at higher temperatures and longer exposure times. Glucose addition provided the highest extent of reaction, while MR-chitosan/COS1 films exhibited the best antioxidant behavior.
Article
Polymer Science
Soumaya Boughriba, Rim Nasri, Suming Li, Moncef Nasri, Nabil Souissi
Summary: This study investigated the effect of different pretreatment methods on the physicochemical properties of gelatin extracted from Rhinobatos cemiculus skin. The results showed that ultrasound and bleaching were the best techniques for obtaining thermally stable gelatins.
Article
Biochemistry & Molecular Biology
Mohammad Kazem Medlej, Simon Le Floch, Ghassan Nasser, Suming Li, Akram Hijazi, Celine Pochat-Bohatier
Summary: Polysaccharides were extracted from Ornithogalum using ultrasound treatment, and the composition and adhesion strength of the extracts were evaluated. The results showed that the extraction parameters had a significant impact on the extracts. Rheological measurements were used to determine the state of the extract solutions, and their potential as environmentally friendly adhesive was tested on different substrates. The study suggested that these polysaccharide extracts could be promising tissue adhesives in medical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Polymer Science
Yuandou Wang, Shuxin Wang, Wenju Hu, Feng Su, Fusheng Liu, Suming Li
Summary: Amphiphilic block copolymers were synthesized and photo-crosslinked hydrogels were prepared. The hydrogels exhibited high swelling and excellent biocompatibility. Drug loading efficiency and release rate were dependent on the hydrogel properties. Hydrogels with higher drug concentration and shorter hydrophobic block length showed higher anti-cancer activity. Therefore, these hydrogels have great potential for long-term local cancer therapy.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2022)
Article
Food Science & Technology
Youssra Ben Azaza, Marwa Hamdi, Christophe Charmette, Mourad Jridi, Suming Li, Moncef Nasri, Rim Nasri
Summary: This study developed active packaging films based on chitosan and sardinella protein, improving structural and thermal properties of the films. Incorporating more sardinella protein into the packaging films enhanced the chemical properties and microbial stability of the wrapped shrimps during cold storage.
FOOD PACKAGING AND SHELF LIFE
(2022)
Article
Materials Science, Paper & Wood
Youssra Ben Azaza, Marwa Hamdi, Christophe Charmette, Arie van Der Lee, Mourad Jridi, Suming Li, Moncef Nasri, Rim Nasri
Summary: In this study, composite films based on blue crab chitosan and bluefin tuna collagenous proteins were prepared and characterized. The addition of bluefin tuna collagenous proteins improved the barrier properties and antioxidant activity of the composite films. Furthermore, the Cs-BTCP coating demonstrated effective preservation of shrimps.
Article
Polymer Science
Ping Zhang, Chaoqun Zhang, Jie Song, Shuxin Wang, Qian Li, Feng Su, Suming Li
Summary: A novel nanoprobe using fluorescein 5-isothiocyanate (FITC), hyaluronic acid (HA), and polyethyleneimine (PEI) functionalized graphene oxide (GO) was developed for the detection of hyaluronidase as a cancer marker. The nanoprobe showed high sensitivity and selectivity, and could enter cells by specifically binding to the CD44 receptor on the surface of Hela cells. It has potential application in targeted tumor cell imaging for the early diagnosis of cancers.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Chemistry, Multidisciplinary
J. Song, X. Shen, F. Liu, X. Zhao, Y. Wang, S. Wang, P. Wang, J. . Wang, F. Su, S. Li
Summary: In this study, a Ca2+-based metal-organic framework (UTSA-280) was developed to encapsulate amylases in situ, resulting in increased relative activity of the enzymes. It was found that the released amylase from UTSA-280 had more Ca2+ on its surface, leading to stronger activation of the enzyme. Furthermore, UTSA-280 provided protection for the enzymes against various factors, making it a promising material for enzyme preparation with activity-promoting and protective effects.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Yuandou Wang, Shuxin Wang, Wenju Hu, Shaowen Kong, Feng Su, Fusheng Liu, Suming Li
Summary: A triblock copolymer PCL-PEG-PCL was successfully synthesized and functionalized, and hydrogels composed of acrylated PEG-PCL-Acr and MPEG-Acr or PEG-Acr were prepared by visible light exposure. The hydrogels exhibited a porous and interconnected structure, and their swelling performance depended on crosslinking density and hydrophilic content. In vitro degradation was achieved, and the hydrogels showed good biocompatibility. In situ gelation was achieved by irradiation in mice, and the drug-loaded hydrogels exhibited sustained release and antitumor activity against lung cancer cells.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Article
Polymer Science
Chihao Gao, Lixia Pan, Jie Song, Min Wei, Haozhi Sun, Feng Su, Xin Shen, Suming Li
Summary: In this study, a prolonged sustained-release system of NPs@Gel for the delivery of valsartan was achieved by preparing poly(ethylene glycol)-b-poly(lactide-co-glycolide) (PEG-PLGA) nanoparticles loading valsartan and carboxymethyl chitosan/aldehyde sodium hyaluronate hydrogels. The addition of nanoparticles significantly reduced the swelling ratios of the hydrogels and enhanced their mechanical properties. The NPs@Gel composites also exhibited excellent biocompatibility.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Polymer Science
Xinshuang Zhao, Le Kang, Baogang Zhang, Li Liu, Haozhi Sun, Xin Shen, Feng Su, Suming Li
Summary: Silver nanoparticles were prepared and embedded in a biodegradable poly(butylene adipate terephthalate) matrix. The resulting nanocomposite films showed improved properties and exhibited excellent antibacterial activity, stability, and barrier performance, suggesting great potential for various applications.
POLYMERS FOR ADVANCED TECHNOLOGIES
(2023)
Article
Chemistry, Applied
Jie Song, Chaoqun Zhang, Shaowen Kong, Fangyu Liu, Wenju Hu, Feng Su, Suming Li
Summary: This study aims to develop a novel chitosan based metal-organic polyhedrons (MOPs)/enzyme hybrid hydrogel with superior antimicrobial properties for wound healing treatment. The results show that the hydrogel exhibits better bactericidal effect and good cell compatibility, effectively facilitating wound healing. Therefore, the chitosan based MOPs/enzyme hybrid hydrogel holds great promise for antibacterial therapy in clinical applications.
CARBOHYDRATE POLYMERS
(2022)
