Journal
MACROMOLECULAR BIOSCIENCE
Volume 14, Issue 5, Pages 667-678Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201300481
Keywords
biodegradable polymers; biomedical applications; glass transition temperature; polymer blends; shape memory polymers
Funding
- National Research Foundation of Korea - Ministry of Science, ICT & Future Planning (MSIP) [2012-0001047, 2012M3A9C6049717]
- Industrial Strategic Technology Development Program - Ministry of Trade, Industry and Energy (MOTIE) [10043971]
- KIST Program - MSIP, Republic of Korea [2E23720]
- National Research Foundation of Korea [2012M3A9C6049717] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Specific biodegradable polymers having shape-memory properties through polymer-blend'' method are investigated and their shape-switching in body temperature (37 degrees C) is characterized. Poly(L-lactide-co-caprolactone) (PLCL) and poly(L-lactide-co-glycolide) (PLGA) are dissolved in chloroform and the films of several blending ratios of PLCL/PLGA are prepared by solvent casting. The shape-memory properties of films are also examined using dynamic mechanical analysis (DMA). Among the blending ratios, the PLCL50/PLGA50 film shows good performance of shape-fixity and shape-recovery based on glass transition temperature. It displays that the degree of shape recovery is 100% at 37 degrees C and the shape recovery proceeds within only 15 s. In vitro biocompatibility studies are shown to have good blood compatibility and cytocompatibility for the PLCL50/PLGA50 films. It is expected that this blended biodegradable polymer can be potentially used as a material for blood-contacting medical devices such as a self-expended vascular polymer stents and vascular closure devices in biomedical applications.
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