Journal
MACROMOLECULAR BIOSCIENCE
Volume 14, Issue 11, Pages 1627-1638Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201400214
Keywords
delivery of biologicals; drug delivery; macromolecules loading; nanocarriers; NiNOS
Funding
- Higher Education Commission of Pakistan (HEC, Pak.)
- German Academic Exchange Service (DAAD)
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Gelatin nanoparticles can be stabilized by entrapping them in Eudragit E100 nanospheres. The size of the nanospheres was dependent on the homogenization speed, producing nanospheres of 433 nm (8000 rpm) and 176nm (15000 rpm). The nanoparticle morphology was critically dependent on Eudragit E100 concentration; with 2% Eudragit E 100 nanospheres showed spherical depressions (pores) of around 90nm on the surface. The number of porous particles decreased from 68% to 5% when Eudragit1 E 100 concentration was increased to 6%, which in turn improved gelatin entrapment from 55% to 93% respectively. Additionally, the initial burst release of gelatin was decreased from 30% to 10% respectively.
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