New Perspectives of HPMA-based Copolymers Derived by Post-Polymerization Modification

The scope of nanoparticle therapies for future metastatic melanoma treatment

(2014) Francesca Baldelli Bombelli et al.   LANCET ONCOLOGY

Water-Soluble Polymers Coupled with Glycopeptide Antigens and T-Cell Epitopes as Potential Antitumor Vaccines

(2013) Lutz Nuhn et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Correction to Well-Defined Aminooxy Terminated N-(2-Hydroxypropyl) Methacrylamide Macromers for Site Specific Bioconjugation of Glycoproteins

(2013) Pradeep K. Dhal et al.   BIOCONJUGATE CHEMISTRY

HPMA-LMA Copolymer Drug Carriers in Oncology: An in Vivo PET Study to Assess the Tumor Line-Specific Polymer Uptake and Body Distribution

(2013) Mareli Allmeroth et al.   BIOMACROMOLECULES

Interaction of N-(2-Hydroxypropyl)Methacrylamide Based Homo, Random and Block Copolymers with Primary Immune Cells

(2013) Martin Weilbächer et al.   Journal of Biomedical Nanotechnology

PEGylation of HPMA-based block copolymers enhances tumor accumulation in vivo : A quantitative study using radiolabeling and positron emission tomography

(2013) Mareli Allmeroth et al.   JOURNAL OF CONTROLLED RELEASE

Combining Ring-Opening Multibranching and RAFT Polymerization: Multifunctional Linear–Hyperbranched Block Copolymers via Hyperbranched Macro-Chain-Transfer Agents

(2013) Lutz Nuhn et al.   MACROMOLECULES

Supramolecular Linear-g-Hyperbranched Graft Polymers: Topology and Binding Strength of Hyperbranched Side Chains

(2013) Christian Moers et al.   MACROMOLECULES

Interaction of pHPMA–pLMA Copolymers with Human Blood Serum and Its Components

(2013) Mirjam Hemmelmann et al.   MOLECULAR PHARMACEUTICS

Poly(N-(2-hydroxypropyl) methacrylamide)-based nanotherapeutics

(2013) Bryan S. Tucker et al.   Polymer Chemistry

HPMA Copolymers as Surfactants in the Preparation of Biocompatible Nanoparticles for Biomedical Application

(2012) Annette Kelsch et al.   BIOMACROMOLECULES

Aggregation Behavior of Amphiphilic p(HPMA)-co-p(LMA) Copolymers Studied by FCS and EPR Spectroscopy

(2012) Mirjam Hemmelmann et al.   BIOMACROMOLECULES

Biological Activity of Anti-CD20 Multivalent HPMA Copolymer-Fab’ Conjugates

(2012) Russell N. Johnson et al.   BIOMACROMOLECULES

Anti-CD20 multivalent HPMA copolymer-Fab′ conjugates for the direct induction of apoptosis

(2012) Te-Wei Chu et al.   BIOMATERIALS

Endothelial targeting of polymeric nanoparticles stably labeled with the PET imaging radioisotope iodine-124

(2012) Eric A. Simone et al.   BIOMATERIALS

Amphiphilic HPMA–LMA copolymers increase the transport of Rhodamine 123 across a BBB model without harming its barrier integrity

(2012) Mirjam Hemmelmann et al.   JOURNAL OF CONTROLLED RELEASE

P(HPMA)-block-P(LA) copolymers in paclitaxel formulations: Polylactide stereochemistry controls micellization, cellular uptake kinetics, intracellular localization and drug efficiency

(2012) Matthias Barz et al.   JOURNAL OF CONTROLLED RELEASE

Synthesis of Maleimide-Functionalyzed HPMA-Copolymers and in vitro Characterization of the aRAGE- and Human Immunoglobulin (huIgG)-Polymer Conjugates

(2012) Kristof Tappertzhofen et al.   MACROMOLECULAR BIOSCIENCE

Linear-Hyperbranched Graft-Copolymers via Grafting-to Strategy Based on Hyperbranched Dendron Analogues and Reactive Ester Polymers

(2012) Christoph Schüll et al.   MACROMOLECULES

Molecular imaging with polymers

(2012) Nathan R. B. Boase et al.   Polymer Chemistry

Theranostic Nanomedicine

(2011) Twan Lammers et al.   ACCOUNTS OF CHEMICAL RESEARCH

Synthetic Antitumor Vaccines Containing MUC1 Glycopeptides with Two Immunodominant Domains-Induction of a Strong Immune Response against Breast Tumor Tissues

(2011) Nikola Gaidzik et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Modifying the Body Distribution of HPMA-Based Copolymers by Molecular Weight and Aggregate Formation

(2011) Mareli Allmeroth et al.   BIOMACROMOLECULES

Multimodality and nanoparticles in medical imaging

(2011) Wen-Yen Huang et al.   DALTON TRANSACTIONS

HPMA Based Amphiphilic Copolymers Mediate Central Nervous Effects of Domperidone

(2011) Mirjam Hemmelmann et al.   MACROMOLECULAR RAPID COMMUNICATIONS

Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure–property relationships to better defined therapeutics

(2011) Matthias Barz et al.   Polymer Chemistry

Rational Design of Targeted Cancer Therapeutics through the Multiconjugation of Folate and Cleavable siRNA to RAFT-Synthesized (HPMA-s-APMA) Copolymers†

(2010) Adam W. York et al.   BIOMACROMOLECULES

Copolymerization Behavior ofN-(2-Hydroxypropyl)methacrylamide and a Methacrylated Coiled-Coil Peptide Derivative

(2010) Bojana Apostolovic et al.   BIOMACROMOLECULES

Evaluation of Nanoparticle Aggregation in Human Blood Serum

(2010) Kristin Rausch et al.   BIOMACROMOLECULES

Synthesis and In Vitro Evaluation of Defined HPMA Folate Conjugates: Influence of Aggregation on Folate Receptor (FR) Mediated Cellular Uptake

(2010) Matthias Barz et al.   BIOMACROMOLECULES

72/74As-labeling of HPMA based polymers for long-term in vivo PET imaging

(2010) Matthias M. Herth et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Multiple fluorescent chemical sensing and imaging

(2010) Matthias I. J. Stich et al.   CHEMICAL SOCIETY REVIEWS

N-(2-Hydroxypropyl)methacrylamide-based polymer conjugates with pH-controlled activation of doxorubicin for cell-specific or passive tumour targeting. Synthesis by RAFT polymerisation and physicochemical characterisation

(2010) Petr Chytil et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

MUC1 immunotherapy

(2010) Richard E Beatson et al.   Immunotherapy

Langmuir−Blodgett Films of Biocompatible Poly(HPMA)-block-poly(lauryl methacrylate) and Poly(HPMA)-random-poly(lauryl methacrylate): Influence of Polymer Structure on Membrane Formation and Stability

(2010) Patrick Scheibe et al.   LANGMUIR

Synthesis, Characterization and Preliminary Biological Evaluation of P(HPMA)-b-P(LLA) Copolymers: A New Type of Functional Biocompatible Block Copolymer

(2010) Matthias Barz et al.   MACROMOLECULAR RAPID COMMUNICATIONS

HPMA-based polymer therapeutics improve the efficacy of surgery, of radiotherapy and of chemotherapy combinations

(2010) Twan Lammers et al.   Nanomedicine

PEG conjugates in clinical development or use as anticancer agents: An overview

(2009) Gianfranco Pasut et al.   ADVANCED DRUG DELIVERY REVIEWS

Polymeric carriers: Preclinical safety and the regulatory implications for design and development of polymer therapeutics

(2009) Rogério Gaspar et al.   ADVANCED DRUG DELIVERY REVIEWS

Polymer therapeutics: Clinical applications and challenges for development

(2009) María J. Vicent et al.   ADVANCED DRUG DELIVERY REVIEWS

Combination therapy: Opportunities and challenges for polymer–drug conjugates as anticancer nanomedicines

(2009) Francesca Greco et al.   ADVANCED DRUG DELIVERY REVIEWS

HPMA copolymers: 30years of advances☆

(2009) Twan Lammers et al.   ADVANCED DRUG DELIVERY REVIEWS

Immunogenicity and immunomodulatory properties of HPMA-based polymers☆

(2009) Blanka Říhová et al.   ADVANCED DRUG DELIVERY REVIEWS

HPMA copolymers: Origins, early developments, present, and future☆

(2009) Jindřich Kopeček et al.   ADVANCED DRUG DELIVERY REVIEWS

Micelles based on HPMA copolymers☆

(2009) M. Talelli et al.   ADVANCED DRUG DELIVERY REVIEWS

Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities☆

(2009) Ruth Duncan et al.   ADVANCED DRUG DELIVERY REVIEWS

18F Labeled Nanoparticles forin VivoPET-CT Imaging

(2009) Neal K. Devaraj et al.   BIOCONJUGATE CHEMISTRY

Synthesis and Evaluation of Multivalent Branched HPMA Copolymer−Fab′ Conjugates Targeted to the B-Cell Antigen CD20

(2009) Russell N. Johnson et al.   BIOCONJUGATE CHEMISTRY

Facile Synthesis of Multivalent Folate-Block Copolymer Conjugates via Aqueous RAFT Polymerization: Targeted Delivery of siRNA and Subsequent Gene Suppression†

(2009) Adam W. York et al.   BIOMACROMOLECULES

Radioactive Labeling of Defined HPMA-Based Polymeric Structures Using [18F]FETos for In Vivo Imaging by Positron Emission Tomography

(2009) Matthias M. Herth et al.   BIOMACROMOLECULES

Synthesis of Hetero-Telechelic α,ω Bio-Functionalized Polymers

(2009) Peter J. Roth et al.   BIOMACROMOLECULES

The uptake of N-(2-hydroxypropyl)-methacrylamide based homo, random and block copolymers by human multi-drug resistant breast adenocarcinoma cells

(2009) Matthias Barz et al.   BIOMATERIALS

HPMA copolymer conjugates with reduced anti-CD20 antibody for cell-specific drug targeting. I. Synthesis and in vitro evaluation of binding efficacy and cytostatic activity

(2009) Tomáš Etrych et al.   JOURNAL OF CONTROLLED RELEASE

The Advantages of Nanoparticles for PET

(2009) M. J. Welch et al.   JOURNAL OF NUCLEAR MEDICINE

Postpolymerization modification of poly(pentafluorophenyl methacrylate): Synthesis of a diverse water-soluble polymer library

(2009) Matthew I. Gibson et al.   JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY

Synthesis of Heterotelechelic α,ω Dye-Functionalized Polymer by the RAFT Process and Energy Transfer between the End Groups

(2009) Peter J. Roth et al.   MACROMOLECULES

Synthesis and bioactivity of poly(HPMA)–lysozyme conjugates: the use of novel thiazolidine-2-thione coupling chemistry

(2009) Lei Tao et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biodegradable dendritic positron-emitting nanoprobes for the noninvasive imaging of angiogenesis

(2009) Adah Almutairi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

From Defined Reactive Diblock Copolymers to Functional HPMA-Based Self-Assembled Nanoaggregates

(2008) M. Barz et al.   BIOMACROMOLECULES

A Method for Obtaining Defined End Groups of Polymethacrylates Prepared by the RAFT Process during Aminolysis

(2008) Peter J. Roth et al.   MACROMOLECULES

Molecular imaging in drug development

(2008) Jürgen K. Willmann et al.   NATURE REVIEWS DRUG DISCOVERY

Impact of lipoproteins on the biological activity and disposition of hydrophobic drugs: implications for drug discovery

(2007) Kishor M. Wasan et al.   NATURE REVIEWS DRUG DISCOVERY