Journal
MACROMOLECULAR BIOSCIENCE
Volume 12, Issue 8, Pages 1068-1076Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201100520
Keywords
antibacterial; hydantoin; melt polycondensation; N-halamine
Funding
- The Philipps-University Marburg
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A new N-hydantoin-containing biocompatible and enzymatically degradable polyester with antibacterial properties is presented. Different polyesters of dimethyl succinate, 1,4-butanediol, and 3-[N,N-di(beta-hydroxyethyl)aminoethyl]-5,5- dimethylhydantoin in varying molar ratios are prepared via two-step melt polycondensation. The antibacterially active N-halamine form is obtained by subsequent chlorination of the polyesters with sodium hypochlorite. Chemical structures, thermal properties, and spherulitic morphologies of the copolymers are studied adopting FT-IR, NMR, TGA, DSC, WAXD, and POM. The polyesters exhibit antibacterial activity against Escherichia coli. The adopted synthetic approach can be transferred to other polyesters in a straightforward manner.
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