Journal
MACROMOLECULAR BIOSCIENCE
Volume 12, Issue 10, Pages 1321-1325Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201200205
Keywords
cancer cells; layer-by-layer assembly; magnetic nanoparticles; multifunctional microcapsules; RGD
Funding
- Ministry of Science and Technology of China [2011CB606202, 2009CB930300]
- National Natural Science Funds for Distinguished Young scholar [51125014]
- Fundamental Research Fund for the Central Universities
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Fluorescent-magnetic-biotargeting multifunctional microcapsules (FMBMMs) are designed and fabricated via layer-by-layer assembly. It is found that the arginine-glycine-aspartate-modified FMBMMs were capable of sensitively detecting and efficiently isolating approximately 80% target cancer cells within 20?min. More importantly, FMBMMs present a general template for identifying and separating multiple types of cancer cells simply by altering the recognition motif.
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