Journal
MACROMOLECULAR BIOSCIENCE
Volume 10, Issue 11, Pages 1345-1354Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000146
Keywords
bioartificial kidney; biological application of polymers; hydrogen bonding; membranes; supramolecular structures; tissue engineering
Funding
- SupraPolix
- Dutch Kidney Foundation
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A bioartificial kidney, which is composed of a membrane cartridge with renal epithelial cells, can substitute important kidney functions in patients with renal failure. A particular challenge is the maintenance of monolayer integrity and specialized renal epithelial cell functions ex vivo. We hypothesized that this can be improved by electro-spun, supramolecular polymer membranes which show clear benefits in ease of processability. We found that after 7 d, in comparison to conventional microporous membranes, renal tubular cells cultured on top of our fibrous supramolecular membranes formed polarized monolayers, which is prerequisite for a well-functioning bioartificial kidney. In future, these supramolecular membranes allow for incorporation of peptides that may increase cell function even further.
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