Journal
MACROMOLECULAR BIOSCIENCE
Volume 11, Issue 2, Pages 245-256Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.201000354
Keywords
biological application of polymers; extrusion; melting point; polyurethanes
Funding
- Bando Programma Neuroscienze - Compagnia San Paolo
- Bando Ricerca Sanitaria Finalizzata - Regione Piemonte
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A biocompatible and elastomeric PU was synthesized from low-molecular-weight PCL as macrodiol, CMD as chain extender and HDI as chain linker for applications in the field of peripheral nerve repair. PU cast films supported in vitro attachment and proliferation of NOBEC. The in vitro adhesion and proliferation of S5Y5 neuroblastoma cells on the inner surface of uncoated, gelatin- and PL-coated PU guides were compared. Due to their superior in vitro performance, PL-coated PU guides were tested in vivo for the repair of 1.8 cm-long defects in rat sciatic nerves. The progressive regeneration was confirmed by EMG and histological analysis showing the presence of regenerating fibers in the distal stumps.
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