Journal
MACROMOLECULAR BIOSCIENCE
Volume 8, Issue 7, Pages 645-654Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/mabi.200700329
Keywords
biocompatibility; functionalization of polymers; grafting; scaffolds; surface modification
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Resorbable porous scaffold discs and solid films were prepared from poly[(1,5-dioxepan-2one)-co-(L-lactide)] and poly [(epsilon-caprolactone)-co-(L-lactide)]. The surfaces of the scaffolds were functionalized to increase their hydrophilicity. A total of 90 samples were prepared to cover all important combinations of experimental and material factors, and all experimental data were fitted by a partial least square model. As a result of grafting, the porous discs and solid films exhibited a tremendous increase in wettability. The functionalized discs were hygroscopic so that water was instantly absorbed and thoroughly wet the substrates.
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