Russell body phenotype is preferentially induced by IgG mAb clones with high intrinsic condensation propensity: Relations between the biosynthetic events in the ER and solution behaviors in vitro

Modulation of in vivo IgG crystallization in the secretory pathway by heavy chain isotype class switching and N-linked glycosylation

(2014) Haruki Hasegawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Quantitative Evaluation of Colloidal Stability of Antibody Solutions using PEG-Induced Liquid–Liquid Phase Separation

(2014) Ying Wang et al.   MOLECULAR PHARMACEUTICS

Nondenaturing Size-Exclusion Chromatography-Mass Spectrometry to Measure Stress-Induced Aggregation in a Complex Mixture of Monoclonal Antibodies

(2013) Jonathan Woodard et al.   ANALYTICAL CHEMISTRY

Phase transitions in human IgG solutions

(2013) Ying Wang et al.   JOURNAL OF CHEMICAL PHYSICS

Russell body inducing threshold depends on the variable domain sequences of individual human IgG clones and the cellular protein homeostasis

(2012) Janelle Stoops et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Pathological crystallization of human immunoglobulins

(2012) Y. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystallization and liquid-liquid phase separation of monoclonal antibodies and fc-fusion proteins: Screening results

(2011) Egor Trilisky et al.   BIOTECHNOLOGY PROGRESS

In VivoCrystallization of Human IgG in the Endoplasmic Reticulum of Engineered Chinese Hamster Ovary (CHO) Cells

(2011) Haruki Hasegawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stability of Protein Pharmaceuticals: An Update

(2010) Mark Cornell Manning et al.   PHARMACEUTICAL RESEARCH

Increased aggregation propensity of IgG2 subclass over IgG1: Role of conformational changes and covalent character in isolated aggregates

(2010) Heather Franey et al.   PROTEIN SCIENCE

The use of native cation-exchange chromatography to study aggregation and phase separation of monoclonal antibodies

(2010) Shuang Chen et al.   PROTEIN SCIENCE

Pathogenesis of ER Storage Disorders: Modulating Russell Body Biogenesis by Altering Proximal and Distal Quality Control

(2010) Riccardo Ronzoni et al.   TRAFFIC

High-throughput dynamic light scattering method for measuring viscosity of concentrated protein solutions

(2009) Feng He et al.   ANALYTICAL BIOCHEMISTRY

Relevant shaking stress conditions for antibody preformulation development

(2009) Annette Eppler et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS