Review
Cardiac & Cardiovascular Systems
Taija Makinen, Laurence M. Boon, Miikka Vikkula, Kari Alitalo
Summary: Lymphatic vessels play a crucial role in maintaining tissue fluid homeostasis and immune surveillance. Developmental or functional defects in lymphatic vessels can lead to lymphedema. Recent advancements have identified genetic causes and molecular pathways underlying lymphatic malformations and complex lymphatic anomalies, paving the way for targeted therapies.
CIRCULATION RESEARCH
(2021)
Article
Engineering, Biomedical
Kevin T. Campbell, Matthew B. Curtis, Joshua M. Massey, Kajetan Wysoczynski, Dustin J. Hadley, Steve C. George, Eduardo A. Silva
Summary: Lymphatic dysfunction is associated with the progression of several vascular disorders, and there are limited strategies currently available to promote new lymphatic vasculature. This study isolated lymphatic endothelial progenitor cells from human umbilical cord blood and found that they have the potential to promote lymphatic sprouts, highlighting the therapeutic potential of these cells. Delivery of lymphatic EPCs using alginate hydrogels also showed promise for possible therapeutic applications.
ACTA BIOMATERIALIA
(2021)
Review
Medicine, Research & Experimental
Jangampalli Adi Pradeepkiran, Ashly Hindle, Sudhir Kshirsagar, P. Hemachandra Reddy
Summary: This article discusses the importance of mitochondria in Alzheimer's disease, emphasizing the role of mitophagy in maintaining mitochondrial function and regulating cellular homeostasis. It also summarizes the challenges of pharmacologically inducing mitophagy through different signaling cascades and introduces the effects of mitophagy enhancers on Alzheimer's disease models. Finally, it explores the significant role of mitophagy enhancers in promoting health in Alzheimer's disease patients.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Oncology
Sen Liu, Xu Chen, Tianxin Lin
Summary: The article summarizes the molecular mechanisms of lymphatic metastasis in bladder cancer, including lymphangiogenesis, noncoding RNAs, and microenvironment-associated molecules. Newly discovered radiomics and genomics approaches have improved the preoperative diagnostic accuracy of lymph node metastasis, potentially leading to promising therapeutic strategies.
Review
Medicine, Research & Experimental
Wenjing Xu, Natalie R. Harris, Kathleen M. Caron
Summary: The lymphatic system is receiving increasing attention for its role in diseases and drug delivery. Despite identified crucial lymphatic genes with therapeutic potential, effective targeted therapeutics for human lymphatic pathologies are lacking. Promising therapeutic targets for modulating lymphangiogenesis or lymphatic function are being explored for future clinical applications.
ANNUAL REVIEW OF MEDICINE, VOL 72, 2021
(2021)
Review
Pharmacology & Pharmacy
Tao Liang, Yang Zhang, Suyuan Wu, Qingjie Chen, Lin Wang
Summary: Alzheimer's disease is a common age-related neurodegenerative disease with characteristic pathological features, and the activation of NLRP3 inflammasome plays a crucial role in its pathogenesis. Chronic neuroinflammation is an important factor in the development of AD, and targeting NLRP3 inflammasome pharmacologically can provide new therapeutic strategies.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Laura Dupont, Loic Joannes, Florent Morfoisse, Silvia Blacher, Christine Monseur, Christophe F. Deroanne, Agnes Noel, Alain C. M. A. Colige
Summary: The study demonstrates that ADAMTS2 and ADAMTS14 are as efficient as ADAMTS3 in activating pro-VEGFC and play a crucial role in maintaining the homeostasis of the lymphatic vasculature in adulthood.
Article
Biochemistry & Molecular Biology
Marta Turati, Gianluca Mattei, Alessia Boaretto, Alberto Magi, Maura Calvani, Roberto Ronca
Summary: The lymphatic vascular system plays a crucial role in cancer progression by activating lymphatic endothelial cells and facilitating the formation of new lymphatic vessels. This study revealed that cancer-derived and microenvironmental mediators activate specific molecular pathways in lymphatic endothelial cells, leading to endothelial activation, morphogenesis, and cytokine-mediated signaling. The findings provide new insights into the lymphangiogenesis process and its relevance in different types of tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Ernesto Solorzano, Andrew L. Alejo, Hope C. Ball, Joseph Magoline, Yusuf Khalil, Michael Kelly, Fayez F. Safadi
Summary: Complex Lymphatic Anomalies (CLA) are lymphatic malformations with unknown causes affecting the bone and soft tissue. The extent of lymphatic anomalies and bone invasion varies among different subtypes of CLA. This review compiles literature on the four primary CLA subtypes and discusses their clinical presentation, lymphatic invasion, osseous profile, as well as the regulatory pathways associated with abnormal bone loss caused by lymphatic invasion. Key proliferation and differentiation pathways shared between lymphatics and bone are highlighted, shedding light on the interaction between these systems stimulating lymphangiogenesis and causing bone loss.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Lu Zhang, Dickson Kofi Wiredu Ocansey, Lianqin Liu, Chinasa Valerie Olovo, Xu Zhang, Hui Qian, Wenrong Xu, Fei Mao
Summary: Inflammatory bowel disease (IBD) is characterized by intense immune dysregulation, gut microbiota imbalance, and intestinal epithelium destruction. Recent studies suggest that the lymphatic system plays a significant role in gastrointestinal pathophysiology, affecting immune cells, gut microbiota, intestinal and mesenteric epithelial barrier integrity, and colorectal cancer (CRC) progression. Therapeutic targets of lymphatics in IBD studies aim to increase lymphangiogenesis to restore gut homeostasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Editorial Material
Biochemistry & Molecular Biology
Zhangying Chen, Steven J. Schwulst, Alexios-Fotios A. Mentis
Summary: The three-dimensional graphic design illustrates the potential role of meningeal vessels in Alzheimer disease, showing the clearance of solutes from meningeal lymphatic vessels. The image highlights differences between APOE4(+) and APOE4(-) Alzheimer disease cases outlined in the accompanying Comment article.
MOLECULAR PSYCHIATRY
(2021)
Review
Immunology
Yongle Cai, Jingliu Liu, Bin Wang, Miao Sun, Hao Yang
Summary: This article systematically summarizes the roles of microglia in Alzheimer's disease pathology, including the research on therapeutic targets such as pro-inflammatory genes, anti-inflammatory genes, and phagocytosis. Some of the findings are contradictory and require further investigation.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jing Liu, Chen Yu
Summary: The lymphatic vasculature plays a vital role in maintaining tissue homeostasis, lipid assimilation, and immune regulation. However, the study of initial lymphatic vessels, also known as lymphatic capillaries, has been hindered by technical limitations. This review discusses recent advances in understanding the proliferation and permeability of lymphatic capillaries, as well as their role in renal fibrosis and interaction with other organs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Physiology
Faisal Masood, Rohan Bhattaram, Mark Rosenblatt, Andrius Kazlauskas, Jin-Hong Chang, Dimitri T. Azar
Summary: Aberrant lymphatic system function is linked to various pathologies, and while lymphatic vessel regression and dysfunction can worsen some conditions, induced regression may be beneficial in certain cases. However, our understanding of lymphatic vessel regression lags behind that of blood vessel regression. By studying blood vessel regression, we can uncover hallmarks of this phenomenon that could help us better understand lymphatic vessel regression. Current research tools and models can be utilized to advance this field and gain therapeutic insights into select pathologies.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Physiology
Zarah B. Tabrizi, Nada S. Ahmed, Joseph L. Horder, Sarah J. Storr, Andrew V. Benest
Summary: The lymphatic system is a crucial vascular system with diverse functions in physiology and pathology, serving as an interface between the blood vascular and immune system. While much research has focused on phenotypic switching of blood endothelium, less attention has been given to the functional and molecular heterogeneity of the lymphatic system, where transcription factor activity likely plays an important role in controlling cellular responses during lymphatic remodelling.
FRONTIERS IN PHYSIOLOGY
(2021)
