Article
Chemistry, Multidisciplinary
Deepthi Priyanka Damera, Amit Nag
Summary: This study investigates the alterations in membrane fluidity caused by functionalization of polymers and preparation of giant polymersomes. The functionalized vesicles were able to achieve pH-sensitive release of curcumin with tumor-targeting capability, demonstrating their potential in drug delivery applications.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Analytical
Tianyi Dou, Clara Zens, Katrin Schroeder, Yuan Jiang, Alexey A. Makarov, Stephan Kupfer, Dmitry Kurouski
Summary: Liposomes are a promising therapeutic formulation for targeted drug delivery. AFM-IR analysis can be used to characterize the structure and morphology of liposomes at the single-vesicle level, as well as to investigate the conformational changes in phospholipids during liposome assembly. Additionally, liposomes show great potential for protein internalization.
ANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Multidisciplinary
Wei Yuan, Jiafang Piao, Yuanchen Dong
Summary: This review summarizes the advancements in preparation methods of unilamellar liposomes, and discusses the applications, advantages, and challenges of each method.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Article
Chemistry, Analytical
Tianyi Dou, Clara Zens, Katrin Schroder, Yuan Jiang, Alexey A. Makarov, Stephan Kupfer, Dmitry Kurouski
Summary: Liposomes are promising therapeutic formulations for targeted drug delivery. AFM-IR is a powerful technique that can be used to characterize the structural and morphological changes of lipids in liposomes. The study also demonstrates the rapid internalization of proteins by liposomes using melittin as a test protein. This research provides new insights into the molecular mechanisms of liposome-drug interactions.
ANALYTICAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Naoto Ishida, Kazuki Kamada, Terumasa Omatsu, Kohji Maeda, Yumi Yoshida
Summary: This study demonstrates the uphill accumulation of a hydrophobic cation into the inner phase of a giant unilamellar vesicle through the concentration gradient of the counter anion. The theoretical simulation rationalizes the accumulation behavior and provides insights for the preparation of liposomal drugs.
Article
Chemistry, Applied
Laura Hanley, Saeed M. Ghazani, Alejandro G. Marangoni
Summary: The spontaneous formation of phospholipid vesicles was explored for the production of liposomal encapsulations of bioactive compounds. Stable vesicles were produced from unrefined soybean and sunflower lecithin, and their structure and encapsulation capacity were evaluated. These vesicles demonstrated high thermal and oxidative stability, making them suitable for food applications.
Article
Chemistry, Multidisciplinary
Igor Zhigaltsev, Yuen Yi C. Tam, Jayesh A. Kulkarni, Pieter R. Cullis
Summary: This study develops a bottom-up approach to manufacture drug-loaded hybrid lipid nanoparticles containing gold nanoparticles (LNP-GNPs). The study shows that negatively charged GNPs can be stably loaded into LNPs containing ionizable cationic lipid using an ethanol dilution and rapid mixing approach. Moreover, the system can also entrap ammonium sulfate, enabling pH-dependent loading of the anti-cancer drug doxorubicin. Cryo-transmission electron microscopy confirms the presence of GNPs in the interior of the hybrid nanostructures and the formation of drug precipitates in the aqueous core of the LNP-GNPs.
Article
Pharmacology & Pharmacy
Amanda C. Carita, Jacqueline Resende de Azevedo, Yves Chevalier, Delphine Arquier, Marcus Buri, Karin A. Riske, Gislaine Ricci Leonardi, Marie-Alexandrine Bolzinger
Summary: The study investigates the influence of hydrophilic surfactants on the membrane elasticity of liposomes and their effect on the skin absorption of vitamin C. Encapsulation of vitamin C inside cationic liposomes is aimed at improving its delivery to the skin. Elastic liposomes (ELs) formed by the addition of Polysorbate 80 to conventional liposomes (CLs) were compared. The presence of a positive charge in the liposomal membrane significantly increases the encapsulation efficacy of both CLs and ELs, indicating a potential mechanism involving interactions between cationic lipids and vitamin C during skin diffusion.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Medicine, Research & Experimental
Nojoud Al Fayez, Roland Bottger, Elham Rouhollahi, Pieter R. Cullis, Dominik Witzigmann, Shyh-Dar Li
Summary: The study demonstrated that phospholipid-free small unilamellar vesicles composed of Tween80 and cholesterol could effectively encapsulate and deliver primaquine (PQ) to hepatocytes, reducing exposure to red blood cells and hemolytic toxicity. This approach showed potential in improving the efficacy of PQ for treating liver-stage malaria.
MOLECULAR PHARMACEUTICS
(2022)
Review
Chemistry, Multidisciplinary
Matheus A. Chaves, Leticia S. Ferreira, Lucia Baldino, Samantha C. Pinho, Ernesto Reverchon
Summary: Liposomes have been extensively used in cosmetics and cosmeceuticals for encapsulating drugs and bioactives. In recent years, their application in food has also increased significantly. This study provides a systematic review of technological advancements in nanoencapsulation of vitamins using liposomes, discussing challenges and future perspectives, highlighting the advantages of these drug-loaded nanocarriers for cosmetics and food applications.
Article
Pharmacology & Pharmacy
Nojoud A. L. Fayez, Roland Bottger, Jennifer Brown, Elham Rouhollahi, Shyh-Dar Li
Summary: This study elucidated the hepatocyte targeting mechanism of phospholipid-free small unilamellar vesicles (PFSUVs) and identified the key role of apolipoprotein AII (ApoA2). The study demonstrated that PFSUVs adsorbed plasma ApoA2 to their surface, which was recognized by the scavenger receptor B-1 (SR-B1) expressed on hepatocytes and internalized through clathrin-mediated endocytosis.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Xia Gao, Xiangzhou Yi, Zhongyuan Liu, Xiuping Dong, Guanghua Xia, Xueying Zhang, Xuanri Shen
Summary: This study compared the characteristics and anti-inflammatory effects of two different curcumin liposomes prepared with different phospholipids. The results showed that liposomes prepared with golden pompano head phospholipids exhibited better stability and anti-inflammatory effects.
Article
Biochemistry & Molecular Biology
Xinmao Wang, Yangruizi Zhang, Maobin Xie, Zhibiao Wang, Hai Qiao
Summary: This paper used giant unilamellar vesicles (GUVs) as a cell model to investigate the relationship between environmental temperature changes and the evolution of unicellular to multicellular life. The zeta potential of GUVs and the conformation of the headgroup of phospholipid molecules at different temperatures were examined. The study found that increasing temperature reduced the repulsive forces between cells models and promoted their aggregation. This research contributes to our understanding of the evolution of primitive unicellular to multicellular life.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Food Science & Technology
Feng Jiang, Jingbo Liu, Zhiyang Du, Xuanting Liu, Xiaomin Shang, Yiding Yu, Ting Zhang
Summary: This study investigates the effect of soybean meal peptides on phase separation and reveals the correlation between peptide membrane localization and phase regulation. The results demonstrate that peptides YYK, CLA, and SLW increase the liquid-ordered (Lo) phase while peptide WLQ decreases it. The localization of peptides in the membrane amphiphilic region plays a crucial role in their regulation of phase separation.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Food Science & Technology
San-San Ang, Yin Yin Thoo, Lee Fong Siow
Summary: This study investigated the potential of spray-dried chitosan-coated liposomes as delivery carriers for apigenin. These liposomes showed improved aqueous solubility, higher antioxidant capacity, and stability against simulated gastrointestinal digestion. The chitosan coating allowed for a slower release of apigenin.
FOOD AND BIOPROCESS TECHNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
A. Fleming, F. S. Schenkel, R. A. Ali, M. Corredig, S. Carta, C. M. Gregu, F. Malchiodi, N. P. P. Macciotta, F. Miglior
CANADIAN JOURNAL OF ANIMAL SCIENCE
(2019)
Article
Biochemical Research Methods
Andre Brodkorb, Lotti Egger, Marie Alminger, Paula Alvito, Ricardo Assuncao, Simon Ballance, Torsten Bohn, Claire Bourlieu-Lacanal, Rachel Boutrou, Frederic Carriere, Alfonso Clemente, Milena Corredig, Didier Dupont, Claire Dufour, Cathrina Edwards, Matt Golding, Sibel Karakaya, Bente Kirkhus, Steven Le Feunteun, Uri Lesmes, Adam Macierzanka, Alan R. Mackie, Carla Martins, Sebastien Marze, David Julian McClements, Olivia Menard, Mans Minekus, Reto Portmann, Claudia N. Santos, Isabelle Souchon, R. Paul Singh, Gerd E. Vegarud, Martin S. J. Wickham, Werner Weitschies, Isidra Recio
Article
Agriculture, Dairy & Animal Science
Isis Rodrigues Toledo Renhe, Zhengtao Zhao, Milena Corredig
JOURNAL OF DAIRY RESEARCH
(2019)
Review
Agriculture, Dairy & Animal Science
Milena Corredig, Pulari Krishnakutty Nair, Ying Li, Hadi Eshpari, Zhengtao Zhao
JOURNAL OF DAIRY SCIENCE
(2019)
Article
Agriculture, Dairy & Animal Science
Zhengtao Zhao, Milena Corredig, Zafir Gaygadzhiev
JOURNAL OF DAIRY SCIENCE
(2019)
Article
Agriculture, Dairy & Animal Science
J. S. Zhang, M. Corredig, R. Morales-Rayas, A. Hassan, M. W. Griffiths, G. LaPointe
JOURNAL OF DAIRY SCIENCE
(2019)
Article
Agriculture, Dairy & Animal Science
N. Rafiee-Tari, M. Z. Fan, T. Archbold, E. Arranz, M. Corredig
JOURNAL OF DAIRY SCIENCE
(2019)
Article
Food Science & Technology
Ying Li, Milena Corredig
JOURNAL OF TEXTURE STUDIES
(2020)
Article
Biotechnology & Applied Microbiology
Ruiqin Wu, Xiaohui Xing, Milena Corredig, Baozhong Meng, Mansel W. Griffiths
Article
Biochemistry & Molecular Biology
Romina Zanabria, Mansel W. Griffiths, Milena Corredig
JOURNAL OF FOOD BIOCHEMISTRY
(2020)
Article
Food Science & Technology
M. Villalva, L. Jaime, E. Arranz, Z. Zhao, M. Corredig, G. Reglero, S. Santoyo
FOOD RESEARCH INTERNATIONAL
(2020)
Article
Agriculture, Dairy & Animal Science
Zhengtao Zhao, Isis Renhe, Robert Fu, Milena Corredig
JOURNAL OF DAIRY RESEARCH
(2020)
Article
Food Science & Technology
Marcello Alinovi, Germano Mucchetti, Ulf Andersen, Tijs A. M. Rovers, Betina Mikkelsen, Lars Wiking, Milena Corredig
Article
Chemistry, Applied
Zhengtao Zhao, Milena Corredig
Article
Biochemistry & Molecular Biology
N. Rafiee Tari, E. Arranz, M. Corredig