Article
Chemistry, Applied
Ruru Liu, Ying Xu, Ming Chang, Ruijie Liu, Xingguo Wang
Summary: The study observed an antagonistic effect of different concentrations of alpha-tocopherol and gamma-oryzanol in an oil-in-water emulsion. The concentration of the antioxidants played a role in the degree of antagonism, with gamma-oryzanol inhibiting the regeneration of alpha-tocopherol. These findings can guide further research on the mechanism of antioxidant interaction in emulsion systems.
Article
Food Science & Technology
Harshika Arora, Mitch D. Culler, Eric A. Decker
Summary: This study investigated the potential use of enzyme-modified high-PS lecithin in combination with alpha-tocopherol to extend the lag phase of oil-in-water emulsions. The combination of enzyme-modified high-PS lecithins and alpha-tocopherol showed synergistic antioxidant activity and could be a commercially viable strategy to control lipid oxidation in emulsions.
Article
Chemistry, Multidisciplinary
Xuemeng Guo, Junlei Zhang, Xu Liu, Yichao Lu, Yingying Shi, Xiang Li, Sije Wang, Jiaxin Huang, Huihui Liu, Huanli Zhou, Qingpo Li, Lihua Luo, Jian You
Summary: Glaucoma, the third leading cause of blindness worldwide, is primarily characterized by elevated intraocular pressure. Prolonged high intraocular pressure damages retinal cells and current treatments primarily focus on reducing intraocular pressure. Researchers have developed a novel nanoemulsion that prolongs ocular retention and effectively mitigates retinal cell damage associated with glaucoma.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Agriculture, Multidisciplinary
Raffaella Inchingolo, Ipek Bayram, Sibel Uluata, S. Sezer Kiralan, Maria T. Rodriguez-Estrada, D. Julian McClements, Eric A. Decker
Summary: Increased surfactant micelles can enhance the effectiveness of alpha-tocopherol by reducing its prooxidant activity in oil-in-water emulsions. Alpha-tocopherol added post-homogenization led to higher concentrations in the continuous phase when SDS levels exceeded the critical micelle concentration, while pre-emulsification addition did not increase SDS concentrations in the continuous phase.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Acoustics
Libin Sun, Hong Wang, Xiang Li, Sheng Lan, Junguo Wang, Dianyu Yu
Summary: In this study, casein was used as a carrier system for alpha-tocopherol, forming an amphiphilic self-assembling micellar nanostructure with ultrasound treatment. The UV-Vis spectra of alpha-TOC/CN nanoparticles complexes varied with different ultrasonic treatments, indicating improved stability of alpha-TOC and stronger antioxidant activity of the nanoparticles compared to free samples.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Amira Awadalla, Mohamed R. Mahdi, Mohamed H. Zahran, Ahmed Abdelbaset-Ismail, Mohamed El-Dosoky, Amr Negm
Summary: This study investigated the protective effect of baicalein and alpha-tocopherol in cisplatin-induced nephrotoxicity. The results showed that baicalein and alpha-tocopherol can enhance antioxidant status, reduce inflammation, and improve renal histopathology.
Article
Food Science & Technology
Takahiko Mitani, Yasuko Yawata, Nami Yamamoto, Mitsunori Nishide, Hidefumi Sakamoto, Shin-ichi Kayano
Summary: This study demonstrates that the addition of an appropriate amount of α-tocopherol can effectively stabilize hydroxy-α-sanshool in sansho extracts, and maintaining the close proximity of HαS and α-tocopherol in emulsions can further enhance the stability.
Review
Biochemistry & Molecular Biology
Fleur L. Meulmeester, Jiao Luo, Leon G. Martens, Kevin Mills, Diana van Heemst, Raymond Noordam
Summary: Oxidative stress is a major contributor to lifestyle- and age-related diseases. Antioxidant supplementation has been proposed as a method to delay and improve these diseases, but clinical trials have failed to provide evidence for its benefits. This review discusses recent developments and research techniques in clarifying the controversy surrounding antioxidant supplementation in health and disease.
Article
Agriculture, Dairy & Animal Science
Y. X. Zhang, W. C. Ke, D. Vyas, A. T. Adesogan, M. Franco, F. H. Li, J. Bai, X. S. Guo
Summary: This study found that inoculation with the high-antioxidant Lactobacillus plantarum strain 24-7 improved the fermentation quality and antioxidant status of ensiled alfalfa forage.
ANIMAL FEED SCIENCE AND TECHNOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Tamara Stela Mendonca Azevedo, Lavinia Kelly Barros Silva, Alvaro Silva Lima, Matheus Mendonca Pereira, Elton Franceschi, Cleide Mara Faria Soares
Summary: This study conducted a computational analysis on the biotransformation of alpha-tocopherol into tocopherol esters, observing the tunnels in enzymatic structures and the energies related to molecule transport. Results revealed variations in the quantity of tunnels in different lipases, with CALB identified as the enzyme most likely to transport substrates during alpha-tocopherol biotransformation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Grazia Pastorelli, Rachida Benamri, Massimo Faustini, Roberta De Bellis, Valentina Serra, Lauretta Turin, Marc Haumont, Philippe Durand, Laura Bianchessi, Emmanuelle Prost-Camus, Thomas Pecqueur, Michel Prost
Summary: This study investigated the effect of dietary inclusion of commercial polyphenol products (PPs) on the growth performance, antioxidant status, and immunity of post-weaning piglets. The results showed that replacing vitamin E with PPs can partially substitute vitamin E in post-weaning piglets.
Article
Biochemistry & Molecular Biology
Brian Head, Jane La Du, Carrie Barton, Jie Zhang, Carmen Wong, Emily Ho, Robyn L. Tanguay, Maret G. Traber
Summary: The vitamin E regulatory protein, alpha-tocopherol transfer protein (Ttpa), is crucial for zebrafish embryo development. A fluorescent-tagged zebrafish transgenic line was created using CRISPR-Cas9 technology to study Ttpa function, showing fluorescence in various parts of RedEfish embryos at different developmental stages. This model provides valuable insights for studying Ttpa function during embryo development.
Article
Food Science & Technology
Ying Xu, Yiwen Guo, Ruru Liu, Ruijie Liu, Ming Chang
Summary: This study investigates the stability and antioxidant potential of α-tocopherol and γ-oryzanol at different concentrations. The results show that the addition of minor constituents increases the particle size and decreases lipolysis extent. Oxygen radical absorption capacity exhibits good antioxidant activity in the small intestine and micelles, while the cellular antioxidant activity results indicate unsatisfactory antioxidant activity in cells.
FOOD RESEARCH INTERNATIONAL
(2022)
Article
Chemistry, Physical
Dhana Lakshmi Manyala, Moulie Ghosh, Sridhar Dalai
Summary: Oil-in-water (o/w) microemulsions (MEs) are being widely researched as nanocarriers for hydrophobic bioactive molecules for various applications. The challenge lies in formulating stable MEs using biodegradable and biocompatible components in low concentration.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Biochemistry & Molecular Biology
Sonia Trombino, Teresa Poerio, Federica Curcio, Emma Piacentini, Roberta Cassano
Summary: In this study, alpha-tocopherol-loaded nanoparticles based on chitosan were successfully produced using membrane emulsification. The results demonstrated that these nanoparticles have a high degree of uniformity, high encapsulation efficiency, and good mechanical strength, while preserving the biological activity and antioxidant properties of alpha-tocopherol.
