Journal
LUPUS
Volume 27, Issue 12, Pages 1898-1902Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0961203318797417
Keywords
Intestine; macrophages; mucosal immunity; systemic lupus erythematosus disease
Categories
Funding
- National Institute of Allergy and Infectious Diseases grant [AI091526, AI1288864]
- Medical Research Service at the Ralph H. Johnson VA Medical Center Merit grant VA CSRD MERIT [CX001211]
- National Institute of Arthritis and Musculoskeletal and Skin Diseases grant [P60 AR062755, UL1 RR029882]
- BLRD MERIT [BX000470]
- Beijing Natural Science Foundation [7152063]
- Scientific Research Common Program of Beijing Municipal Commission of Education [KM2016100250017]
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Monocytes play an important role in inducing host systemic immunity against invading pathogens and inflammatory responses. After activation, monocytes migrate to tissue sites, where they initiate both innate and adaptive immune responses, and become macrophages. Although mucosal macrophages produce inflammatory cytokines in response to pathogens, the perturbations in innate immune signaling pathway have been implicated in autoimmune diseases such as systemic lupus erythematosus (SLE). In this review, we focus on the role of human macrophages in intestinal innate immune responses, homeostasis, and SLE disease. We further discuss sex differences in the intestinal macrophages and their role in the physiology and pathogenesis of SLE.
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