Journal
LUPUS
Volume 23, Issue 12, Pages 1309-1312Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/0961203314538332
Keywords
Antiphospholipid antibodies; antiphospholipid syndrome; thrombosis; venous thrombosis; antiprothrombin; anti-phosphatidylserine; stroke
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Funding
- Louise Gergel Fellowship
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Antibodies to prothrombin can be detected by ELISA using prothrombin coated onto irradiated plates (aPT) or the phosphatidylserine/prothrombin complex as antigen (aPS/PT) and they have been both related with the clinical manifestation of APS. Current evidence supports the concept that they belong to distinct populations of autoantibodies. Nevertheless, they can both be detected simultaneously in one patient. This mini-review will focus on data available on aPS/PT antibodies and their clinical utility in the diagnosis of APS.
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